Wednesday July 17, 2019

Two-part Ebola vaccine may offer protection for a year against the deadly disease

An immune response was induced by the vaccine that persisted for approximately one year in volunteers according to results from the phase-1 clinical trial

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FILE - A health worker, center, takes the temperature of people to see if they might be infected by the Ebola virus inside the Ignace Deen government hospital in Conakry, Guinea, March 18, 2016. VOA

New York, March 15, 2017: A two-part Ebola vaccine regimen has been found to offer protection against the deadly disease for about a year in an early human trial.

The vaccine regimen induced an immune response that persisted for approximately one year in healthy adult volunteers, according to results from the phase-1 clinical trial published in the Journal of the American Medical Association.

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The experimental vaccines included Ad26.ZEBOV, developed by Johnson & Johnson, and MVA-BN-Filo, developed by Denmark-based Bavarian Nordic.

Both of the vaccines in the regimen use harmless viral vectors, or carriers, to deliver proteins of the Ebola virus, which prompt an immune response.

The trial, conducted by Matthew D. Snape of the University of Oxford and colleagues, enrolled healthy participants aged 18-50 years in Britain.

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Participants were selected randomly to receive either the two-vaccine regimen or placebo (saltwater injections).

Previously reported initial results showed the two-vaccine regimen is safe, well-tolerated and induced immune responses in participants eight months after immunisation.

Of the 75 participants who received the vaccine regimen, 64 remained in the study for a follow-up visit on day 360.

No serious vaccine-associated adverse events were observed, and all 64 participants maintained antibodies to Ebola virus at day 360.

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The researchers noted that additional research is necessary to assess the durability of immunity beyond one year and the immune response to booster doses of vaccine. (IANS)

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Patient Isolated in Swedish Hospital Amid Ebola Suspicion

A suspected case of the deadly Ebola virus has been reported by a Swedish hospital, officials said Friday, adding that the patient has been isolated.

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- The exterior of the University Hospital in Enkoping, Sweden, is seen in this Feb. 4, 2009 photo. Officials say a Swedish hospital has reported a suspected case of the deadly Ebola virus; results of the medical test are expected Jan. 4, 2019, VOA

A suspected case of the deadly Ebola virus has been reported by a Swedish hospital, officials said Friday, adding that the patient has been isolated.

Region Uppsala, which oversees several hospitals and medical clinics north of Stockholm, says a test had been carried out on the patient, who was not identified, adding a result would be available late Friday.

In its statement, Region Uppsala said it was so far “only a matter of suspicion,” adding “other diseases are quite possible.”

It did not say where the patient had traveled, but Sweden’s TT news agency said the patient had returned from a trip to Burundi three weeks ago and had not visited any region with the Ebola virus.

World Health Organization representation of Ebola virus.

The authorities said the hospital in Enkoping where the patient was first admitted had its emergency room shut down and the staff who treated the patient were “cared for.” The patient was eventually transferred to an infection clinic in Uppsala.

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“The patient came in Friday morning and reportedly was vomiting blood which may be a symptom of Ebola infection,” hospital spokesman Mikael Kohler told local newspaper Upsala Nya Tidning. He was not immediately available for further comment.

Eastern Congo currently faces an Ebola outbreak. All major outbreaks have been in Africa, though isolated cases have been reported outside the continent. The hemorrhagic fever’s virus is spread via contact with the bodily fluids of those infected. (VOA)