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A drug commonly used to control high blood pressure may be also effective in preventing the onset of Type 1 diabetes in up to 60 percent of those at risk, researchers say.

The drug, methyldopa, has been used for over 50 years to treat high blood pressure in pregnant women and children and is also on the World Health Organization’s list of essential drugs.


Methyldopa was found to block a molecule called DQ8 — found in some 60 percent at the risk of getting Type 1 diabetes — which significantly increases the chance of getting the disease.

Blocking specifically the DQ8 molecule could also block the onset of the disease, the study found.

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“This is the first personalized treatment for Type 1 diabetes prevention,” said Aaron Michels, Associate Professor of medicine at University of Colorado – Anschutz.

“With this drug, we can potentially prevent up to 60 percent of Type 1 diabetes in those at the risk for the disease. This is very significant development,” Michels added.

Type 1 Diabetes

For the study, published in the Journal of Clinical Investigation, the team used a supercomputer, on the lab bench, in mice, and in humans.

They found that methyldopa not only blocked DQ8, but it did not also harm the immune function of other cells like many immunosuppressant drugs do.

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“We can now predict with almost 100 percent accuracy who is likely to get Type 1 diabetes. The goal, with this drug, is to delay or prevent the onset of the disease among those at risk,” Michels said.

The drug is taken orally, three times a day.

Besides, diabetes, the same approach of blocking specific molecules can be used in other autoimmune diseases such as rheumatoid arthritis, coeliac disease, multiple sclerosis, systemic lupus erythematosus and others, the researchers noted. (IANS)


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Amaal represents the new generation of Indian music.

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Fortnite users look forward to new features

By Steve Carty

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Fortnite has a huge map with different pinned locations in it. It's a game that you can't master in a week or two. It can take months or even years depending on how much you practice. People spend hours in creative just to learn a new technique with the building. Some people have been playing since the launch of Fortnite and are still bad at the game. Yes! It's possible to be bad even after you practice a lot. I'd suggest you spend a lot of time in creative and just free build there to get good at it. Once you've mastered the art of building, you'll be good to go and can outbuild anyone for high ground. There is another thing called editing in this game. People use the latest working Fortnite hacks for this where it edits in 0.1 seconds. People won't even see you editing this and this will make you a step ahead of them and due to that, you can easily kill them before they even notice.

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