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Common BP Drug May Prevent Onset Of Type 1 Diabetes

For the study, published in the Journal of Clinical Investigation, the team used a supercomputer, on the lab bench, in mice, and in humans

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Type 1 Diabetes
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A drug commonly used to control high blood pressure may be also effective in preventing the onset of Type 1 diabetes in up to 60 percent of those at risk, researchers say.

The drug, methyldopa, has been used for over 50 years to treat high blood pressure in pregnant women and children and is also on the World Health Organization’s list of essential drugs.

Methyldopa was found to block a molecule called DQ8 — found in some 60 percent at the risk of getting Type 1 diabetes — which significantly increases the chance of getting the disease.

Blocking specifically the DQ8 molecule could also block the onset of the disease, the study found.

 

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“This is the first personalized treatment for Type 1 diabetes prevention,” said Aaron Michels, Associate Professor of medicine at University of Colorado – Anschutz.

“With this drug, we can potentially prevent up to 60 percent of Type 1 diabetes in those at the risk for the disease. This is very significant development,” Michels added.

Type 1 Diabetes

For the study, published in the Journal of Clinical Investigation, the team used a supercomputer, on the lab bench, in mice, and in humans.

They found that methyldopa not only blocked DQ8, but it did not also harm the immune function of other cells like many immunosuppressant drugs do.

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“We can now predict with almost 100 percent accuracy who is likely to get Type 1 diabetes. The goal, with this drug, is to delay or prevent the onset of the disease among those at risk,” Michels said.

The drug is taken orally, three times a day.

Besides, diabetes, the same approach of blocking specific molecules can be used in other autoimmune diseases such as rheumatoid arthritis, coeliac disease, multiple sclerosis, systemic lupus erythematosus and others, the researchers noted. (IANS)

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Now Comes a Shoe Insole That Could Treat Foot Ulcers Caused Due to Diabetes

A patent is pending on the insole technology. The team is currently seeking corporate partners

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The findings, published in the journal Diabetologia, were based on data from nearly 2,800 children with a first-degree relative with Type-1 diabetes.
New shoe insole could treat diabetic foot ulcers. Pixabay

Researchers have developed a shoe insole that could help make the healing process more portable for people who develop ulcers as a result of diabetes.

Diabetic ulcers commonly result from high blood sugar damaging nerves, which takes away feeling from the toes or feet.

“One of the ways to heal these wounds is by giving them oxygen,” said Babak Ziaie, Professor at the Purdue University in the US.

“We’ve created a system that gradually releases oxygen throughout the day so that a patient can have more mobility.”

Without the ability to feel pain, hits and bumps tend to go unnoticed and skin tissue breaks down, forming ulcers.

A lot of sugar in the bloodstream, along with dried skin as a result of diabetes, further slow the ulcer healing process.

The researchers used lasers to shape silicone-based rubber into insoles, and then create reservoirs that release oxygen only at the part of the foot where the ulcer is located.

Diabetes
Representational image. Pixabay

“Silicone is flexible and has good oxygen permeability,” said Hongjie Jiang, a post-doctoral researcher at the varsity.

“Laser machining helps us to tune that permeability and target just the wound site, which is hypoxic, rather than poison the rest of the foot with too much oxygen,” Jiang added.

In a paper published in the journal Materials Research Society Communications, the team said the insole can deliver oxygen at least eight hours a day under the pressure of someone weighing about 53-81 kg.

It can also be customised to take on any weight, the study said.

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The team envisions a manufacturer sending a patient a pack of pre-filled insoles customised to his or her wound site, based on a “wound profile” obtained from a doctor’s prescription and a picture of the foot.

“This is mass-customisation at low cost,” said Vaibhav Jain, research associate at Purdue.

A patent is pending on the insole technology. The team is currently seeking corporate partners. (IANS)