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Common BP Drug May Prevent Onset Of Type 1 Diabetes

For the study, published in the Journal of Clinical Investigation, the team used a supercomputer, on the lab bench, in mice, and in humans

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A drug commonly used to control high blood pressure may be also effective in preventing the onset of Type 1 diabetes in up to 60 percent of those at risk, researchers say.

The drug, methyldopa, has been used for over 50 years to treat high blood pressure in pregnant women and children and is also on the World Health Organization’s list of essential drugs.

Methyldopa was found to block a molecule called DQ8 — found in some 60 percent at the risk of getting Type 1 diabetes — which significantly increases the chance of getting the disease.

Blocking specifically the DQ8 molecule could also block the onset of the disease, the study found.

 

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“This is the first personalized treatment for Type 1 diabetes prevention,” said Aaron Michels, Associate Professor of medicine at University of Colorado – Anschutz.

“With this drug, we can potentially prevent up to 60 percent of Type 1 diabetes in those at the risk for the disease. This is very significant development,” Michels added.

Type 1 Diabetes

For the study, published in the Journal of Clinical Investigation, the team used a supercomputer, on the lab bench, in mice, and in humans.

They found that methyldopa not only blocked DQ8, but it did not also harm the immune function of other cells like many immunosuppressant drugs do.

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“We can now predict with almost 100 percent accuracy who is likely to get Type 1 diabetes. The goal, with this drug, is to delay or prevent the onset of the disease among those at risk,” Michels said.

The drug is taken orally, three times a day.

Besides, diabetes, the same approach of blocking specific molecules can be used in other autoimmune diseases such as rheumatoid arthritis, coeliac disease, multiple sclerosis, systemic lupus erythematosus and others, the researchers noted. (IANS)

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Avoid Diabetes With Yoga, Weight Lifting

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity

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Avoid Diabetes by practicing Yoga. Pixabay

If you wish to avoid diabetes, better start exercising for just half-an-hour a day, a Harvard University research has found while advising yoga and weight lifting.

According to the research, the chance of developing Type 2 diabetes was cut by between 30 and 40 per cent with just three-and-a-half hours of exercise a week, Daily Mail reported Wednesday.

It was also found that just an hour’s workout every week could cut the risk by 13 percent.

The study, which followed 100,000 women, also showed muscle-strengthening exercises such as yoga and weight lifting fend off the condition.

Scientists showed that those doing at least 150 minutes of aerobic activity a week – and at least an hour of muscle-strengthening – had the best results.

Weight Lifting
Weight Lifting. Pixabay

Published by the journal PLOS Medicine, the study was carried out by scientists from Harvard School of Public Health and the University of Southern Denmark.

Researchers studied 99,316 middle-aged and older women, who did not have diabetes at the beginning of the study, for eight years. During the period, 3,491 women developed Type 2 diabetes.

They studied the effects of weekly time spent on resistance exercise, lower intensity muscular conditioning exercises and aerobic moderate and vigorous physical activity.

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“Our study suggests that engagement in muscle-strengthening and conditioning activities (resistance exercise, yoga, stretching, toning) is associated with a lower risk of (Type 2 diabetes),” the researchers said.

“Despite limitations to which this research can be applied to women in general, it underlines the message that leading an active healthy lifestyle can help to reduce the risk of Type 2 diabetes,” said Richard Elliott, research communications officer at Diabetes, UK. (IANS)

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