Tuesday December 18, 2018

Type 2 Diabetes May Flare Up Due To Ketogenic Diet :Study

"Diabetes is one of the biggest health issues we face. Although ketogenic diets are known to be healthy, findings indicate that there may be an increased risk of insulin resistance with this type of diet that may lead to Type-2 diabetes."

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Diet, weight may influence bipolar disorder treatment Flickr
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Consuming a ketogenic diet — high in fat but low in protein and carbohydrates — may increase the risk of developing Type-2 diabetes while helping in weight loss, a new study has claimed, raising questions whether the diet is healthy.

The study conducted on mice showed that animals fed on ketogenic diets appear metabolically healthy in the fasted state after 3 days of dietary challenge, whereas obesogenic high-fat diet fed animals showed elevated insulin levels.

It is because in ketogenic diets, the process for controlling blood sugar levels did not work properly and there was insulin resistance in the liver.

Insulin is released in the blood and used to control blood sugar levels including signalling the liver to stop producing sugar.

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Ketogenic Diet increases risk of diabetes, while helping in weight loss. Flickr

If this system is impaired and the body does not use insulin properly, which is called insulin resistance, individuals are likely to develop high blood sugar levels, leading to an increased risk of Type 2 diabetes, the researchers explained.

“Diabetes is one of the biggest health issues we face. Although ketogenic diets are known to be healthy, our findings indicate that there may be an increased risk of insulin resistance with this type of diet that may lead to Type-2 diabetes, said Christian Wolfrum, Associate Professor at the ETH Zurich in Switzerland.

Also Read: Preventing Type 2 Diabetes With the Help of Weight Loss

For the study, published in the Journal of Physiology, the team involved two mice groups: one fed with a ketogenic diet and other a high fat diet.

The team was able to determine the effects of internal sugar production from the animal (mostly the liver), and sugar uptake into tissues (mostly the muscle), during insulin action.(IANS)

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What Triggers Chronic Fatigue Syndrome?

IoPPN professor Carmine Pariante stressed that while the study's main finding is a useful addition to scant scientific knowledge about CFS

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CFS
Lauren Pestikas sits as she receives an infusion of the drug ketamine during a 45-minute session at an outpatient clinic in Chicago on July 25, 2018. VOA

Scientists exploring what may trigger a complex disorder known as chronic fatigue syndrome (CFS) have found clues in the way some people’s immune systems respond more actively to a health attack.

A severe illness characterized by long-term physical and mental fatigue, CFS is thought to affect up to 17 million people worldwide and around 250,000 people in Britain.

Sufferers are often bed-bound and unable to carry out basic daily activities like washing and feeding themselves.

The researchers used a drug known as interferon alpha to create a model of the syndrome and found that patients whose immune response to treatment was hyperactive or exaggerated were more likely to then develop severe fatigue.

CFS
Russell’s team used this knowledge and measured fatigue and immune system markers in 55 patients before, during and after treatment with interferon alpha.

“For the first time, we have shown that people who are prone to develop a CFS-like illness have an overactive immune system, both before and during a challenge to the immune system,” said Alice Russell of King’s College London’s Institute of Psychiatry, Psychology & Neuroscience (IoPPN), who led the work.

The condition, as well as research into it, is highly contentious, in part because its possible causes and range of debilitating symptoms are poorly understood.

Interferon alpha is used as a treatment for hepatitis C infection, and activates the immune system in the same way as a powerful infection. Many patients who receive interferon alpha experience extreme fatigue during treatment, and some continue to feel chronic fatigue for many months after the drug course is completed.

Vaccination, CFS
Biologist Jason Plyler prepares to test at the National Institutes of Health in Bethesda. VOA

Russell’s team used this knowledge and measured fatigue and immune system markers in 55 patients before, during and after treatment with interferon alpha.

They found that the 18 of those 55 who went on to develop a CFS-like illness had a hyperactive immune system before treatment, and an highly overactive response during treatment. “(This suggests) people who have an exaggerated immune response to a trigger may be more at risk of developing CFS,” Russell told reporters at a briefing about the findings.

Also Read: Regular Sleep in Childhood Leads to Healthy BMI Later

IoPPN professor Carmine Pariante stressed that while the study’s main finding is a useful addition to scant scientific knowledge about CFS – also known as myalgic encephalopathy (ME) – it offers few clues on how to treat, cure or prevent it.

“It’s a light in the fog,” he told reporters. “But a better understanding of the biology underlying the development of CFS is needed to help patients.” (VOA)