Wednesday November 20, 2019

Unused Coffee Bean Extracts can Reduce Fat-Induced Inflammation in Cells

It's been shown to be non-toxic

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Coffee Bean, Extracts, Fat
This material from coffee beans is interesting mainly because of its composition. Pixabay

Coffee is beneficial for health we all know, but unused coffee bean extracts can also help reduce fat-induced inflammation in the cells and improved glucose absorption and insulin sensitivity, find researchers.

When coffee beans are processed and roasted the husk and silverskin of the bean are removed and unused, and often are left behind in fields by coffee producers.

Food science and human nutrition researchers at the University of Illinois have discovered inflammation-fighting phenolic compounds — protocatechuic acid and gallic acid — in the silverskin and husk of coffee beans not only for their benefits in alleviating chronic disease but also in adding value to would-be ‘waste’ products from the coffee processing industry.

“This material from coffee beans is interesting mainly because of its composition. It’s been shown to be non-toxic. And these phenolics have a very high anti-oxidant capacity,” said Elvira Gonzalez de Mejia, Professor of food science and co-author of the study published in Food and Chemical Toxicology.

Coffee Bean, Extracts, Fat
When coffee beans are processed and roasted the husk and silverskin of the bean are removed and unused, and often are left behind in fields by coffee producers. Pixabay

When fat cells of mice were treated with water-based extracts from coffee beans skins, the phenolic compounds reduced fat-induced inflammation in the cells and improved glucose absorption and insulin sensitivity.

The findings show promise for these bioactive compounds, when consumed as part of the diet, as a strategy for preventing obesity-related chronic illnesses, such as Type 2 diabetes and cardiovascular disease.

For the study, the fat cells and immune cells were cultured together to recreate the ‘real-life’ interaction between the two cells.

When obesity-related inflammation is present, the fat cells and immune cells work together — stuck in a loop–to increase oxidative stress and interfere with glucose uptake, worsening the situation.

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In order to block this loop and prevent chronic disease, the researchers’ goals are to eliminate or reduce as much inflammation as possible in order to allow glucose uptake to be facilitated, as well as to have healthy cells that will produce adequate insulin.

The researchers also stressed the positive impact on the environment of using the coffee bean by-products.

During coffee processing, the bean is separated from the husk, the external outer layer of the bean. After the bean is roasted, the silverskin layer is separated.

“It’s a huge environmental problem because when they separate this husk after processing, it usually stays in the field fermenting, growing mold, and causing problems,” explained de Mejia.

Coffee Bean, Extracts, Fat
Food science and human nutrition researchers at the University of Illinois have discovered inflammation-fighting phenolic compounds — protocatechuic acid and gallic acid — in the silverskin and husk of coffee beans not only for their benefits. Pixabay

Worldwide, 1,160,000 tonnes of husk are left in fields per year, potentially causing contamination.

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Additionally, 43,000 tonnes of silverskin is produced each year, which, de Mejia adds, may be easier to utilize because it stays with the bean as it is exported to different countries to be roasted. (IANS)

Next Story

Lead Intake Promotes Accumulation of Fat in Liver which Can Cause Obesity

And the actual number could be higher as the condition often goes undiagnosed

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Epidemiological studies have shown that this affects nine to 32 per cent of the Indian population. Pixabay

Researchers at the Indian Institute of Technology, Mandi have shown how lead intake promotes accumulation of fat in the liver which can cause obesity.

The scientists have unravelled the mechanism by which lead salt can promote fat accumulation in the liver.

Epidemiological studies have shown that this affects nine to 32 per cent of the Indian population. And the actual number could be higher as the condition often goes undiagnosed.

Non-alcoholic fatty liver disease (NAFLD) is a dangerous epidemic of this generation and is a rapidly growing health problem intimately related to the metabolic group of diseases such as obesity and diabetes, among others.

Lead, Fat, Obesity
Researchers at the Indian Institute of Technology, Mandi have shown how lead intake promotes accumulation of fat in the liver which can cause obesity. Pixabay

It is a conditioAlson wherein there is excessive fat accumulation in the liver.

While obesity has been known to be the leading cause for NAFLD, recent observations have shown that even thin people can be metabolically ‘obese’ and have NAFLD.

Their research work was performed in collaboration with researchers from the Council of Scientific and Industrial Research (CSIR), Indian Institute of Toxicology Research in Lucknow and School of Chemical and Life Sciences in Jamia Hamdard in New Delhi.

This research work has recently been published in a reputed peer-reviewed journal “FEBS Letters”.

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Prosenjit Mondal, Assistant Professor, School of Basic Sciences, IIT Mandi, who has uncovered the pathway by which lead promotes NAFLD, said: “While the connection between lead and fatty liver disease has been known for a while, the actual mechanism by which lead worsens this condition has hitherto remained unknown.”

NAFLD and most metabolic group of diseases are often caused by the poor regulation of De novo lipogenesis, a complex process in which carbohydrates circulating in the blood are converted into fat.

The poor regulation of De novo lipogenesis leads to abnormal production of fat, which settles in the liver and other internal organs as visceral fat.

It has been found that the metal lead, which is a serious environmental toxin, can lead to poor regulation of fat formation and deposition in the liver.

Lead, Fat, Obesity
The scientists have unravelled the mechanism by which lead salt can promote fat accumulation in the liver. Pixabay

Lead toxicity is a serious concern in India and the use of lead containing paints, pesticides, packaging and even beer contributes towards high exposure of Indians to this toxic metal and its salts.

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Lead salts absorbed by the human body is stored in soft tissues, and autopsy studies have shown that the liver hoards almost 33 per cent of the total lead cruising in the body. (IANS)