Tuesday October 15, 2019

US Invents Oral Capsule To Remit Insulin Through Injection

US Scientists Design Oral Insulin Capsule to Treat Diabetes

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Insulin
US Scientists invent capsules to deliver Insulin Through Injections. Pixabay

Scientists in the US have designed an oral drug capsule that can carry insulin and protect it from the harsh environment in the digestive tracts.

The study published in this week’s Nature Medicine has shown that the capsule containing proteins that cannot be taken orally reaches the small intestine before breaking down to release dissoluble tiny needles, the Xinhua news agency reported.

Those needles then attach to the intestinal wall and release drug for fast uptake into the bloodstream, according to the study.

In tests in pigs, researchers from Massachusetts Institute of Technology (MIT) showed that this capsule could load a comparable amount of insulin to that of an injection.

Treatment of Diabetes By Insulin
Treatment of Diabetes becomes easy as the new Insulin capsule can inject its contents into the wall of the Small Intestine. Pixabay

Earlier this year, they developed a blueberry-sized capsule containing a small needle made of compressed insulin. Upon reaching the stomach, the needle injects the drug into the stomach lining. In the new study, the researchers developed a capsule that could inject its contents into the wall of the small intestine.

They coated the 30-millimeter-long capsule with a polymer that can survive the acidic environment of the stomach. The capsule breaks open in the small intestine as the pH is higher, and then springs three folded arms containing patches of one-millimeter-long needles that can carry insulin, according to the study.

Insulin
The Capsules injected through Needles will Also Allow Reduce the risk of Blockage in the intestine. Pixabay

When the arms unfold open, the force of their release allows the needles to just penetrate the topmost layer of the small intestine tissue. After insertion, the needles dissolve and release the drug.

Also, the arms would break apart after the needle patches are applied to reduce the risk of blockage in the intestine.

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“We can deliver insulin, but we see applications for many other therapeutics and possibly vaccines,” said Giovanni Traverso at MIT. (IANS)

Next Story

Rotavirus Relates to Development of Type 1 Diabetes

Researchers suggests that Rotavirus infection might play a role in the generation of Type 1 Diabetes

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Diabetes
Rotavirus vaccination can contribute to the primary prevention of Type 1 Diabetes. Pixabay

Researchers from the University of Melbourne have found that rotavirus infection might play a role in the development of type 1 diabetes.

Rotavirus remains the major cause of infantile gastroenteritis worldwide, although the advent of vaccination has substantially decreased associated mortality.

Following the recent introduction of rotavirus vaccination, there has been a 15 per cent decrease in the incidence of type 1 diabetes in Australian children under four years of age.

“Vaccination against rotavirus may have the additional benefit in some children of being a primary prevention for type 1 diabetes,” said the study’s lead author Leonard C. Harrison.

Diabetes
The recent introduction of rotavirus vaccination, there has been a 15 per cent decrease in the incidence of type 1 Diabetes in Australian children. Pixabay

The study published in the journal PLOS suggested that rotavirus vaccination could contribute to the primary prevention of this autoimmune disease.

This finding complements human and animal studies implicating rotavirus in the development of type 1 diabetes in genetically susceptible children.

In the article, the research team begin by reviewing molecular evidence supporting their hypothesis and point out the association between rotavirus infection and serum islet autoantibodies.

Diabetes
Rotavirus infection might play a role in the development of type 1 Diabetes. Pixabay

The results showed that rotavirus infection-induced pancreatic pathology, as well as environmental factors that promote the rise in the incidence of type 1 diabetes.

After reviewing population-level data, the study suggested that rotavirus vaccination might be associated with a decrease in the incidence of type 1 diabetes.

According to the researchers, it will be important to identify which children are most likely to be protected by rotavirus vaccination.

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Moreover, future studies should aim to reveal disease mechanisms and directly demonstrate whether rotavirus infects human pancreas prior to the onset of islet autoimmunity or type 1 diabetes. (IANS)