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The new combined vaccination approach could potentially be used to induce strong immune responses to both of the hallmark pathologies of Alzheimer's disease in Brain. Pixabay

A preventive treatment for Dementia Disease may proceed to clinical trials after successful animal testing, say researchers.

The research is looking to develop effective immunotherapy via a new vaccine to remove ‘brain plaque’ and tau protein aggregates linked to Alzheimer’s disease.


Recent success in bigenic mice models supports progression to human trials in years to come, the research added.

The study, published in the journal Alzheimer’s Research & Therapy paves the way for more work in 2020 ith medical researchers at the Institute for Molecular Medicine and University of California, Irvine (UCI) working with a successful vaccine formulated on adjuvant developed by Flinders University Professor Nikolai Petrovsky in Australia.

The researchers tested the universal MultiTEP platform-based vaccines formulated in the adjuvant developed at Australian lab.

The possible new therapies were tested in bigenic mice with mix and tau pathologies.

“Taken together, these findings warrant further development of this dual vaccination strategy based on the MultiTEP technology for ultimate testing in human Alzheimer’s disease,” said the study lead authors Professor Anahit Ghochikyan and Mathew Blurton-Jones.

Professor Petrovsky said the Advax adjuvant method is a pivotal system to help take the combination MultiTEP-based A�/tau vaccines therapy, as well as separate vaccines targeting these pathological molecules, to clinical trials – perhaps within two years.

“Our approach is looking to cover all bases and get past previous roadblocks in finding a therapy to slow the accumulation of A�/tau molecules and delay Alzheimer’s disease progression in a the rising number of people around the world,” Petrovsky added.

Several promising drug candidates have failed in clinical trials so the search for new preventions or therapies continues.

A recent report on human monoclonal antibody, aducanumab, showed that high dose of this antibody reduced clinical decline in patients with early Alzheimer’s disease as measured by primary and secondary endpoints.


The research is looking to develop effective immunotherapy via a new vaccine to remove ‘brain plaque’ and tau protein aggregates linked to Alzheimer’s disease. Pixabay

However, it is obvious that it could not be used as a preventive measure in healthy subjects due to the need for frequent (monthly) administration of high concentrations of immunotherapeutic.

There is a pressing need to keep searching for new preventive vaccine to delay Alzheimer’s disease and slow down progression of this devastating disease.

ALSO READ: WhatsApp to Stop Working on Millions of Older Mobile Devices Globally from January 1

The new combined vaccination approach could potentially be used to induce strong immune responses to both of the hallmark pathologies of Alzheimer’s disease in a broad population base of vaccinated subjects with high MHC (major histocompatibility complex) class II gene polymorphisms, the study concluded. (IANS)


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Milky Way galaxy as seen from Chitkul Valley

NASA's Chandra X-ray Observatory has for the first time spotted signs of a planet transiting a star outside of the Milky Way galaxy, opening up a new avenue to search for exoplanets at greater distances than ever before.

The possible exoplanet -- or planets outside of our Solar System -- candidate is located in the spiral galaxy Messier 51 (M51), also called the Whirlpool Galaxy because of its distinctive profile, NASA said in a statement.

Astronomers have, so far, found all other known exoplanets and exoplanet candidates in the Milky Way galaxy, almost all of them less than about 3,000 light-years from Earth.

An exoplanet in M51 would be about 28 million light-years away, meaning it would be thousands of times farther away than those in the Milky Way, NASA said.

"We are trying to open up a whole new arena for finding other worlds by searching for planet candidates at X-ray wavelengths, a strategy that makes it possible to discover them in other galaxies," said Rosanne Di Stefano of the Center for Astrophysics at Harvard and Smithsonian (CfA) in Cambridge, Massachusetts, who led the study.

The findings are published in the journal Nature Astronomy.

The exoplanet candidate was spotted in a binary system called M51-ULS-1, located in M51. This binary system contains a black hole or neutron star orbiting a companion star with a mass about 20 times that of the Sun. The X-ray transit they found using Chandra data lasted about three hours, during which the X-ray emission decreased to zero.

Based on this and other information, the team estimates the exoplanet candidate in M51-ULS-1 would be roughly the size of Saturn and orbit the neutron star or black hole at about twice the distance of Saturn from the Sun.

The team looked for X-ray transits in three galaxies beyond the Milky Way galaxy, using both Chandra and the European Space Agency's XMM-Newton. Their search covered 55 systems in M51, 64 systems in Messier 101 (the "Pinwheel" galaxy), and 119 systems in Messier 104 (the "Sombrero" galaxy).

However, more data would be needed to verify the interpretation as an extragalactic exoplanet. One challenge is that the planet candidate's large orbit means it would not cross in front of its binary partner again for about 70 years, thwarting any attempts for a confirming observation for decades, NASA said.

Named in honor of the late Indian-American Nobel laureate, Subrahmanyan Chandrasekhar, the Chandra X-ray Observatory is the world's most powerful X-ray telescope. It has eight times greater resolution and is able to detect sources more than 20-times fainter than any previous X-ray telescope.

Known to the world as Chandra (which means "moon" or "luminous" in Sanskrit), Chandrasekhar was widely regarded as one of the foremost astrophysicists of the twentieth century. (IANS/JB)


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