Monday January 27, 2020

Vatican Children’s Hospital Carries Out A Pioneering Surgery On a 30-month-old

Surgeons performing a laparoscopy have an extremely detailed picture of the patient's anatomy, allowing more precise incisions with a lower risk of bleeding.

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Toddler receives mother's kidney, part of liver in pioneering transplant. Pixabay

Surgeons at the Vatican children’s hospital in Rome have carried out a pioneering surgery in which a Lebanese woman’s kidney and part of her liver were transplanted in her 30-month-old son, who suffers from a rare metabolic disorder.

Doctors at the Bambin Gesu hospital performed path-breaking laparoscopic surgery on the left side of the woman’s liver and on her kidney.

The boy, named Danil, suffers from primary hyperoxaluria, a severe form of a rare metabolic disease called oxalosis, characterised by the formation of calcium oxalate deposits in organs and tissues.

Oxalosis can cause urinary infections and permanent kidney damage, and in the most severe cases, can stunt the patient’s growth and cause brittle bones that are vulnerable to fractures. It affects one in 100,000-333,000 people.

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All such patients treated at the Bambin Gesu have had dialysis during surgery and several days afterwards, and all the operations have been successful. Flickr

“This operation could be the first of its kind in the world,” the Bambin Gesu said in a statement.

“We are not aware of previous cases in which laparoscopic surgery has been carried out to transplant the same donor’s liver and kidney one after the other.”

The team at the Bambin Gesu that carried out the laparoscopic transplant in Danil of part his mother’s liver was led by Marco Spada, while the transplant of her kidney to the toddler was spearheaded by Luca dello Strologo.

Laparoscopic surgery to transplant a kidney from a living donor to a recipient is well-established, while the use of the minimally invasive technique for liver transplants is a more recent operation that is only done in the most specialist centres and, in Italy, currently only at the Bambin Gesu.

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Bambin Gesu hospital , Vatican. Flickr

All such patients treated at the Bambin Gesu have had dialysis during surgery and several days afterwards, and all the operations have been successful, according to the hospital. In the past 24 months, it has performed 32 liver or kidney transplants from living donors and 98 from deceased donors.

Also Read: Exposure to Arsenic, Lead may Spike up Risk of Heart Disease

The advantages of laparoscopy include a significant reduction in surgical trauma which reduces the length of time patients need to spend in hospital, less need for painkilling drugs, a lower risk of postoperative complications and a more rapid return to normal life, according to the experts.

And thanks to high-resolution (3K and 4K) and three-dimensional imaging technology, surgeons performing a laparoscopy have an extremely detailed picture of the patient’s anatomy, allowing more precise incisions with a lower risk of bleeding. (IANS)

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Skin Cream Used To Treat Warts, Skin Cancer May Help in Fighting Against Dengue, Zika Viruses

By boosting the immune system and not targeting a specific virus, this strategy has the potential to be a 'silver bullet' for a wide range of distinct mosquito-borne viral diseases

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A study shows that a clinically approved, widely used skin cream has the potential to be repurposed as a valuable protector against insect-borne diseases. Pixabay

A skin cream used to treat warts and skin cancer could help protect people against viral diseases such as Zika and dengue, according to new study.

The cream, called imiquimod or Aldara, is commonly used to treat genital warts and some forms of skin cancer.

“This study shows that a clinically approved, widely used skin cream has the potential to be repurposed as a valuable protector against insect-borne diseases,” said study lead author Clive McKimmie, from the University of Leeds in UK.

For the findings, published in the journal Science Translational Medicine, researchers studied four types of virus transmitted by mosquitos and found that applying a cream within an hour of a mosquito bite dramatically reduced infection rates in their models.

They used two different models to understand the effect of the skin cream – human skin samples and mice. In both cases, applying the skin cream acted like a warning signal which caused a rapid activation of the skin’s immune response that fights any potential viral threats. This prevented the virus from spreading around the body and causing disease.

“What is especially encouraging about our results is that the cream was effective against a number of distinct viruses, without needing to be targeted to one particular virus,” McKimmie said. “If this strategy can be developed into a treatment option then we might be able to use it to tackle a wide range of new emerging diseases that we have not yet encountered,” McKimmie added.

There are hundreds of viruses spread by biting mosquitoes which can infect humans. These include the dengue virus, West Nile virus, Zika virus and chikungunya virus, which have all had large outbreaks in recent years. At present, there are no anti-viral medicines and few vaccines to help combat these infections.

According to the researchers, when a mosquito bites the skin, the body reacts in a very specific way to try and mitigate the physical trauma of the skin being punctured. The bite causes a wound healing repair mechanism to begin, however, the skin does not prepare itself to respond to viral attack. This means mosquito-borne viruses that enter the skin through a bite are able to replicate quickly with little anti-viral response in the skin and then spread throughout the body, the study said.

Cream, Lotion, Hands, Sunscreen, Spa, Skin, Wellness
A skin cream used to treat warts and skin cancer could help protect people against viral diseases such as Zika and dengue, according to new study. Pixabay

By applying skin cream after a bite, researchers found that they could pre-emptively activate the immune system’s inflammatory response before the virus becomes a problem. The cream encouraged a type of immune cell in the skin, called a macrophage, to suddenly spring into action to fight off the virus before it could spread around the body.

ALSO READ: Cannabis Usage Common in Adults with Pain Disorders: Study

“By boosting the immune system and not targeting a specific virus, this strategy has the potential to be a ‘silver bullet’ for a wide range of distinct mosquito-borne viral diseases,” said study co-author Steven Bryden. (IANS)