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Oral intake of vitamin B3 could potentially help prevent acute kidney injury that affects 30-40 per cent of all hospitalised adults in the low-income countries, suggests a study, led by a researcher of Indian-origin.
Acute kidney injury, an often fatal condition without a specific treatment, causes a build-up of waste products in the blood and an imbalance of fluids throughout the body.
The findings showed that levels of nicotinamide adenine dinucleotide (NAD+) — the end result of vitamin B3 after it is ingested — declines in cases of acute kidney injury.
“We were able to detect a drop in NAD+ in the urine of high-risk patients who were either in an intensive care unit or undergoing a major surgery and found that oral vitamin B3 could safely elevate NAD+ in high-risk patients,” said principal investigator Samir M. Parikh, nephrologist and associate professor at Harvard University.
“These findings are very early, but the results suggest that we could one day have a non-invasive test for NAD+ status and perhaps even treat acute kidney injury by boosting NAD+ levels,” he added.
In the study, published in the journal Nature Medicine, the team examined the metabolic changes associated with acute kidney injury in a mouse model. A urine screen revealed high levels of quinolinate.
They then created a mouse model with reduced QRPT — an enzyme responsible for converting quinolinate to NAD+ — but no kidney injury.
The genetically altered rodents mimicked the pattern of acute kidney injury; decreased NAD+, increased urinary quinolinate and increased susceptibility to kidney injury. The experiments were the first to establish QRPT as a mediator of renal stress resistance.
In subsequent human studies, the team found high urinary quinolinate in patients undergoing major surgery at risk for acute kidney injury and confirmed this metabolite pattern in a separate study of 329 intensive care unit patients also at risk for acute kidney injury.
The team then gave large doses of oral vitamin B3 to 41 cardiac surgery patients enrolled in a Phase 1 pilot study and found that augmenting vitamin B3 levels may be safe and potentially beneficial to patients. (IANS)
By Venkatachari Jagannathan
Officials of the Indian space sector, both serving and retired, are of the view that the space sector's organisational structure is expected to mirror that of India's atomic energy sector.
They also said that senior officials of the Indian space agency should address the employees on what is happening in the sector and how it will pan out so that uncertainty and confusion are addressed.
In the Indian atomic energy sector, the Department of Atomic Energy (DAE) is at the top, the Atomic Energy Regulatory Board (AERB) is the sectoral regulator while the Nuclear Power Corporation of India (NPCIL), the Bharatiya Nabhikiya Vidyut Nigam Ltd (both power companies), the Uranium Corporation of India Ltd, the Electronics Corporation of India Ltd, and IREL (India) Ltd are public sector units (PSU).
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The Bhabha Atomic Energy Centre (BARC), Indira Gandhi Centre for Atomic Research (IGCAR) are the premier research and development (R&D) organizations and there are several DAE-aided organizations.
While the DAE is headed by a Secretary (normally from the R&D units) who is also the head of the Atomic Energy Commission (AEC), the R&D centres and PSUs are headed by different persons.
Similarly, the government that has started the space sector reforms seems to be replicating the atomic energy model, several officials told IANS.
"The Central government's moves in the space sector seems to replicate the atomic energy model," an official told IANS.
Currently, the Department of Space (DOS) is at the top and below that, comes the private sector space regulator Indian National Space Promotion and Authorization Centre (IN-SPACe), the Indian Space Research Organization (ISRO) with various R&D-cum-production (rockets, satellites and others) units.
The sector has two PSUs - Antrix Corporation Ltd and NewSpace India Ltd.
Unlike the atomic energy sector, the Secretary of the DOS and Chairman of the Space Commission is also the Chairman of the ISRO.
As part of the space sector reform measures, the government has set up IN-SPACe as a regulator for the private sector players.
"Ultimately there will be only one sectoral regulator. There cannot be two regulators - one for the private sector and other for the public sector. Who will be the regulator if there is a company that is floated in public-private partnership," an official asked.
"It is good that there is a separate sectoral regulator outside of the DOS and the ISRO," an official said.
The recently-formed PSU NewSpace India has been mandated to build, own satellites, rockets and also provide space based services and transfer ISRO-developed technologies to others.
ISRO Chairman and Secretary DOS K.Sivan has been saying that ISRO will focus on high end research.
As a result, the positions of Secretary, DOS and Chairman, ISRO may not be held by the same person.
"Looking forward, there are possibilities of the government coming out with a voluntary retirement scheme for ISRO officials and merging its various production centres with NewSpace to synergise its operations," a former senior official of ISRO told IANS.
"But there is one issue in this proposition. For ISRO, the production centres are also its R&D centre. Both production and R&D are interwoven. One has to see how both will be separated to be housed under ISRO and NewSpace India."
Meanwhile, the minds of ISRO officials are filled with uncertainty and confusion about their future which is linked to that of their organization.
ISRO Staff Association General Secretary G.R.Pramod had told IANS that there is "uncertainty all around about the future of about 17,300 employees of ISRO".
"The ISRO top management that includes the Chairman and the Heads of various centres should come out openly and address the employee concerns at the earliest," an official added.
Space sector reforms are a much-needed move on the part of the government. | Unsplash
Also read: ISO: Achievements and History
According to officials, the uncertainty in the minds of ISRO officials is due to the communication from the government to freeze all recruitment as sectoral reforms are underway - allowing the private sector players in making and launching of satellites and rockets.
The ISRO officials also told IANS that promotions for several categories were kept on hold for the past two years. The promotion exercise for some has been carried out recently.
"Further the number of rocket launches this year from India came down drastically to just two from six or seven per year at an average. Out of two one critical mission for the country had failed," an official said.
However, the unanimous view is that the space sector reforms are a much-needed move on the part of the government so that the resources are used economically.
"For a long time, satellite utilization was an issue. Perhaps the satellites will be launched based on the demand from now onwards. The days of launching a satellite to utilize the rockets and then, searching for customers should be over," an official remarked.
Curiously, officials said all these years, ISRO had not approached its commercial arm Antrix to find out what the market needs so that it can build and launch such satellites.(IANS/PR)
Keywords: Atomic Energy, Satellite, ISRO, Department of Atomic Energy (DAE), DOS
Twitter has announced to ban sharing of private media, such as photos and videos, without permission from the individuals that are shown in those images.
The micro-blogging platform already covers explicit instances of abusive behaviour under its policies, the expansion of the policy will allow the platform to take action on media that is shared without any explicit abusive content, provided it's posted without the consent of the person depicted.
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"Sharing personal media, such as images or videos, can potentially violate a person's privacy, and may lead to emotional or physical harm," Twitter said in a blog post late on Tuesday.
"The misuse of private media can affect everyone, but can have a disproportionate effect on women, activists, dissidents, and members of minority communities. When we receive a report that a Tweet contains unauthorised private media, we will now take action in line with our range of enforcement options," the company informed.
Under the existing policy, publishing other people's private information, such as phone numbers, addresses, and IDs, is already not allowed on Twitter.
This includes threatening to expose private information or incentivising others to do so.
"There are growing concerns about the misuse of media and information that is not available elsewhere online as a tool to harass, intimidate, and reveal the identities of individuals," Twitter said.
When Twitter is notified by individuals depicted, or by an authorised representative, that they did not consent to having their private image or video shared, it removes it.
Twitter founder and CEO Jack Dorsey announced his resignation | Unsplash
Also read: Twitter to label Accounts of Government
This policy is not applicable to media featuring public figures or individuals when media and accompanying Tweet text are shared in the public interest or add value to public discourse.
The expansion of the policy came after Twitter founder and CEO Jack Dorsey announced his resignation, with Indian-origin CTO Parag Agrawal taking over the position.
Twitter in September rolled out a feature called Safety Mode that temporarily blocks certain accounts for seven days if they are found insulting users or repeatedly sending hateful remarks.
Keywords: Twitter, Feature, Private media, Permission
Driven by a surge in digital transformation owing to the pandemic, the IT spending in India is forecast to total $101.8 billion in 2022, an increase of 7 per cent from 2021, global market research firm Gartner said on Wednesday.
In 2022, all segments of IT spending in India are expected to grow, with software emerging as the highest growing segment.
Spending on software is forecast to total $10.5 billion in 2022, up 14.4 per cent from 2021.
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While experiencing a slower growth rate than 2021, spending on software in 2022 is forecast to be nearly double of what it was pre-pandemic.
"India has experienced one of the fastest recoveries despite being one of the worst hit regions in the second wave of the pandemic in early 2021," said Arup Roy, research vice president at Gartner.
As hybrid work adoption increases in the country, there will be an uptick in spending on devices in 2022, reaching $44 billion, an increase of 7.5 per cent from 2021.
The growth in devices is a combination of two componentsUnsplash
Also read: Eight Growing Job Sectors in the US
"The growth in devices is a combination of two components – hybrid work and pent-up demand from 2020 for device upgrades," said Roy. "Spending on devices will make up 43 per cent of total IT spending next year."
Next year, Indian CIOs are prioritizing a move away from rigid and monolithic ways of doing business to a more composable business and IT architecture where they will be able to better respond to disruptions.
"In 2022, CIOs in India will build on renewed interest in technology from the business to gain funding for new IT projects," said Roy.(IANS/PR)
(Keywords: IT sector, Pandemic, Highest growth, Digital Transformation)