Wednesday July 18, 2018

Vitamin C helps in treating Tuberculosis

Taken in diet with medication, it will enhance treatment

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TB is the leading killer of HIV-infected people. In South Africa, 73% of TB patients are HIV positive. Pixabay
TB is the leading killer of HIV-infected people. In South Africa, 73% of TB patients are HIV positive. Pixabay
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Foods rich in Vitamin C (such as dark leafy greens, broccoli, kiwifruit and oranges) can enhance treatment and enable a faster recovery for people suffering from tuberculosis (TB), if taken along with regular medication.

TB is one of the world’s deadliest diseases, with one third of the global population infected. In 2016, it affected 10.4 million people around the world and caused 1.7 million deaths.

Vitamin C helps treating TB. Pexels
Vitamin C helps treating TB. Pexels

Findings

  • Giving Vitamin C — a powerful antioxidant that reduces oxidative stress to the body and also lowers cancer risk — with TB drugs could reduce the unusually long time it takes these drugs to eradicate this pathogen.
  • The addition of Vitamin C to TB drug treatment potentiates the killing of bacterium Mycobacterium tuberculosis (MTB) and could shorten TB chemotherapy.
  • That’s important because treatment of drug susceptible TB takes six months, resulting in some treatment mismanagement, potentially leading to the emergence and spread of drug-resistant TB.

Vitamin C had no activity by itself, but in two independent experiments, the combination of Vitamin C with the first-line TB drugs, isoniazid and rifampicin, reduced the organ burdens faster than the two drugs without vitamin C, said Catherine J. Vilcheze, at the varsity.

“Vitamin C is known to be safe and our current mouse studies suggest that Vitamin C could enhance TB chemotherapy,” said lead investigator William R. Jacobs, from the Albert Einstein College of Medicine in New York.

TB is one of the world's deadliest diseases, with one third of the global population infected. Wikimedia commons
TB is one of the world’s deadliest diseases, with one third of the global population infected. Wikimedia commons

Methodology

  • The team treated MTB-infected mice with anti-TB drugs or vitamin C alone, or the drugs and vitamin C together.
  • Experiments in infected tissue cultures demonstrated similar results, shortening the time to sterilisation of the tissue culture by seven days.

The study was published in the journal Antimicrobial Agents and Chemotherapy. (IANS)

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Cepheid to Establish Manufacturing Unit for TB Diagnostics in India

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment

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The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.
The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach. (IANS)

Expanding its footprint in India, US-based molecular diagnostics company Cepheid Inc on Thursday announced its plans to establish a manufacturing unit in the country to improve Tuberculosis (TB) diagnostics.

Cepheid’s GeneXpert MTB/RIF test is a closed-cartridge-based system that is easy to operate by minimally trained staff and gives results in approximately two hours, speeding the conventional backlog that used to exist in traditional diagnostic methods.

The new manufacturing unit would produce MTB/RIF test cartridges, contribute to the government’s “Make in India” initiative and thus bringing the company’s global expertise in TB diagnostics to India, the company said in a statement.

As part of the plan, Cepheid also unveiled its latest portable, easy-to-use TB-testing system — the GeneXpert Edge — which is expected to be available in India later this year, the company said.

The GeneXpert Edge is developed specifically for near-patient testing, to help support a one visit test-and-treat approach.

“Cepheid recognises the need for technological advancement and is committed to contributing significantly to India’s goal of TB eradication,” said Peter Farrell, Executive Vice President, Worldwide Commercial Operations, Cepheid.

Cepheid's Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB)
Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB).

“We are hopeful that GeneXpert Edge will help eliminate delays in TB diagnostics by providing definitive results within hours and facilitating fast and easy last-mile delivery even in the remote villages of India,” he added.

India has nearly one-fourth of the global TB patients and an estimated 4.8 lakh lives are lost every year due to delayed diagnosis and inadequate treatment and there are above 2.5 million new cases of TB every year. The country aims to eradicate TB by 2025.

Approved by the World Health Organisation (WHO) in 2010, more than 1,200 Cepheid’s GeneXpert Systems have been installed in the last two years at various Revised National Tuberculosis Control Programme (RNTCP) sites in the country and more than 2.5 million cartridges were supplied last year at various centres of Central TB Division (CTD).

Also Read: Fruit Bats Identified As Source Of Nipah Virus Outbreak in Kerala

Cepheid’s Xpert MTB/RIF test has the potential to detect Mycobacterium tuberculosis(MTB) and rifampicin-resistance mutations, which are markers for MDR-TB strains in under two hours.

Rifampicin is a drug commonly used in treating TB bacteria in first line of treatment.

Xpert MTB/RIF tests also have excellent negative predictive value, which allows clinicians to manage TB-negative patients more effectively to prevent unnecessary and costly respiratory isolations. (IANS)