Never miss a story

Get subscribed to our newsletter


×
Researchers have now harnessed information to efficiently eradicate human Pancreatic Cancer cells in xenografts. Pixabay

Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells.

The study, published in the journal Oncotarget, was conducted with xenografts — transplantations of human pancreatic cancer into immunocompromised mice.


The treatment reduced the number of cancer cells by 90 per cent in the developed tumors a month after being administered.

“In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication (mitosis) without affecting normal cells,” said study researcher Malka Cohen-Armon from Tel Aviv University in Israel.

“We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells,” Cohen-Armon added.

According to the researchers, the mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively. This joint research and discovery by carried by the esteemed physician, Dr. Talia Golan M.D in collaboration with TAU Sackler School of Medicine and its professor, Malka Cohen-Armon. Sheba Medical Center is recognised as one of the top 10 hospitals worldwide by Newsweek.

This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death.
Thus, cell multiplication itself resulted in cell death in the treated cancer cells.


Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. Pixabay

A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumuors of the treated mice experienced a relative drop of 90 per cent. In one mouse, the tumuor completely disappeared.

“It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behaviour,” Cohen-Armon added.

ALSO READ: Protein Deficiency Ordinary Among Indians: Experts

This mechanism acts efficiently in other types of cancer resistant to current therapies.

The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin, the study said. (IANS)


Popular

IANS

The Centre will launch a pilot project on the use of indigenously manufactured drones for delivering medicines in the undulating landscape of Jammu and surrounding areas from Saturday

The Centre will launch a pilot project on the use of indigenously manufactured drones for delivering medicines in the undulating landscape of Jammu and surrounding areas from Saturday with a focus on vaccines delivery initially. "This is going to be a pilot project for the area. The drone is developed and manufactured entirely by our scientists," Union Minister for Science & Technology, Dr Jitendra Singh told mediapersons. Singh said he himself will be launching the project at Jammu.

The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL), a constituent of Council of Scientific and Industrial Research (CSIR), an autonomous Society that is headed by the Prime Minister. For now, the delivery would be limited to Covid vaccines and once successful, it would be expanded to be used for regular delivery of medicines in the remote, hilly areas.

drone flying in sky The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL). | Photo by Jason Blackeye on Unsplash

Keep Reading Show less
IANS

According to him Amitabh Bachchan is a great actor in the industry.

Bollywood actor Abhishek Bachchan shares how he feels when people compare him with his father Amitabh Bachchan on the singing reality show 'Sa Re Ga Ma Pa'. He also requests contestant Rajshree Bag to sing a track 'Bahon Mein Chale Aao' featuring his mother Jaya Bachchan.

Abhishek said after looking at the performance of Rajshree, who is often compared with Lata Mangeshkar on the show, that she reminds him of being compared with his father. "Rajshree, whenever I have got the chance to watch the show, I've seen people compare you to Lata didi. It actually reminded me about how people compare me with my father and ask me how I feel about it."

According to him Amitabh Bachchan is a great actor in the industry and this is what he says to everyone making these comparisons. "My answer to them is that there's no greater actor in this film industry than Amitabh Bachchan and if I'm being compared to him, I am sure I must have done something good."

"Similarly, your voice has a different kind of magic like Lata ji and that's why people are comparing your voice with her. I feel you should always take this as a compliment," he concluded. 'Sa Re Ga Ma Pa' airs on Saturday and Sunday on Zee TV. (IANS/ MBI)


Keep Reading Show less
Photo by Aaron Burden on Unsplash

Winters in India have always beckoned for that hot, steaming bowl of tomato and pepper rasam or the mellow, millet based Raab.

By IANSlife

Winters in India have always beckoned for that hot, steaming bowl of tomato and pepper rasam or the mellow, millet based Raab. Certain dishes like sarson ka saag, undhiyu, nimona pulao are winter specialites in the country. Seasonal food has always been an Indian speciality -- we switch our choice in fruits, vegetables, sometimes even grains with the onset of different season. The preference of using specific ingredients during certain climates is visible in our sweets as well. It's common to find local and traditional delicacies made of jaggery, instead of sugar during the winters. Case in point -- the Nolen Gur Rasgulla, a speciality made in Odisha and West Bengal between November to February.

Sarson Ka Saag | Sarson ka saag is traditional Punjabi dish Certain dishes like sarson ka saag, undhiyu, nimona pulao are winter specialites in the country. | Flickr

Keep reading... Show less