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Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells.
The study, published in the journal Oncotarget, was conducted with xenografts — transplantations of human pancreatic cancer into immunocompromised mice.
The treatment reduced the number of cancer cells by 90 per cent in the developed tumors a month after being administered.
“In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication (mitosis) without affecting normal cells,” said study researcher Malka Cohen-Armon from Tel Aviv University in Israel.
“We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells,” Cohen-Armon added.
According to the researchers, the mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively. This joint research and discovery by carried by the esteemed physician, Dr. Talia Golan M.D in collaboration with TAU Sackler School of Medicine and its professor, Malka Cohen-Armon. Sheba Medical Center is recognised as one of the top 10 hospitals worldwide by Newsweek.
This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death.
Thus, cell multiplication itself resulted in cell death in the treated cancer cells.
A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumuors of the treated mice experienced a relative drop of 90 per cent. In one mouse, the tumuor completely disappeared.
“It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behaviour,” Cohen-Armon added.
This mechanism acts efficiently in other types of cancer resistant to current therapies.
The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin, the study said. (IANS)
The Centre will launch a pilot project on the use of indigenously manufactured drones for delivering medicines in the undulating landscape of Jammu and surrounding areas from Saturday with a focus on vaccines delivery initially. "This is going to be a pilot project for the area. The drone is developed and manufactured entirely by our scientists," Union Minister for Science & Technology, Dr Jitendra Singh told mediapersons. Singh said he himself will be launching the project at Jammu.
The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL), a constituent of Council of Scientific and Industrial Research (CSIR), an autonomous Society that is headed by the Prime Minister. For now, the delivery would be limited to Covid vaccines and once successful, it would be expanded to be used for regular delivery of medicines in the remote, hilly areas.
The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL). | Photo by Jason Blackeye on Unsplash
Jammu and surrounding areas are sensitive in terms of the strategic importance. Some months ago, there was an attack on an Army installation using drones. Will the 'drones for vaccines' be permitted in such a case? Allaying fears, a top official from the Ministry of S&T said, "The drones would be deployed by authorised agencies such as hospitals, not anybody can use it, nor would any random person be permitted to use it."
NAL has called the drone as 'Octacopter' and it can fly at an operational altitude of 500 m AGL and at maximum flying speed of 36 kmph. It can be used for a variety of BVLOS applications for last mile delivery like medicines, vaccines, food, postal packets, Human organs (such as heart for heart transplantation) etc. NAL Octacopter is integrated with a powerful on-board embedded computer and latest generation sensors for versatile applications like agricultural pesticide spraying, crop monitoring, mining survey, magnetic geo survey mapping etc., S&T officials had said. (IANS/ MBI)
Keywords: Jammu, Vaccines, Medicines, Deliver, Drones, Centre
Bollywood actor Abhishek Bachchan shares how he feels when people compare him with his father Amitabh Bachchan on the singing reality show 'Sa Re Ga Ma Pa'. He also requests contestant Rajshree Bag to sing a track 'Bahon Mein Chale Aao' featuring his mother Jaya Bachchan.
Abhishek said after looking at the performance of Rajshree, who is often compared with Lata Mangeshkar on the show, that she reminds him of being compared with his father. "Rajshree, whenever I have got the chance to watch the show, I've seen people compare you to Lata didi. It actually reminded me about how people compare me with my father and ask me how I feel about it."
According to him Amitabh Bachchan is a great actor in the industry and this is what he says to everyone making these comparisons. "My answer to them is that there's no greater actor in this film industry than Amitabh Bachchan and if I'm being compared to him, I am sure I must have done something good."
"Similarly, your voice has a different kind of magic like Lata ji and that's why people are comparing your voice with her. I feel you should always take this as a compliment," he concluded. 'Sa Re Ga Ma Pa' airs on Saturday and Sunday on Zee TV. (IANS/ MBI)
Keywords: Abhishek Bachchan, Amitabh Bachchan, reality show, Sa Re Ga Ma Pa, Rajshree Bag
Winters in India have always beckoned for that hot, steaming bowl of tomato and pepper rasam or the mellow, millet based Raab. Certain dishes like sarson ka saag, undhiyu, nimona pulao are winter specialites in the country. Seasonal food has always been an Indian speciality -- we switch our choice in fruits, vegetables, sometimes even grains with the onset of different season. The preference of using specific ingredients during certain climates is visible in our sweets as well. It's common to find local and traditional delicacies made of jaggery, instead of sugar during the winters. Case in point -- the Nolen Gur Rasgulla, a speciality made in Odisha and West Bengal between November to February.
Celebrity chef, Sanjeev Kapoor, strongly advocates this need of eating seasonal produce. He says, "The beauty of our food is in our seasonal usage of fruits and vegetables. If you realise, Gajar ka halwa is made aplenty during winters as this is the season when beautiful red carrots hit the market or mango pickle is made during summer, thanks to its availability. Despite people and sometimes, even me, suggesting that we should eat fresh as well as seasonal fruits and vegetables, we do not know what chemicals are sprayed on them to keep them safe while they are growing. When this produce hits the market, there isn't a certifying agency like the FSSAI that will help people understand what vegetables and fruits are free of pesticides and germs and which ones don't. Hence, the onus lies on us to make them safe for consumption. ITC's Nimwash is a good solution."
When it comes to winters, the Chef recommends eating these fruit and vegetables:
* Purple Mogri -- Mogri or Radish pods are not a common sight throughout the country. But you can spot them during the winters in local markets in northern India where women pick them up to make raitas, curries and stir fries. Rich in magnesium, calcium and copper, the vegetable is known to aid people from digestive problems.
Mogri or Radish pods are not a common sight throughout the country, but you can spot them during the winters | Pixabay
* Sweet Potato -- A re-discovered favourite, Sweet potatoes have created a space for itself in the millennial kitchen. With its diverse addition in burgers, chips and even chat, the root vegetable is filled with nutrients such as fibres and vitamins.
Sweet potatoes have created a space for itself in the millennial kitchen. | Wikimedia Commons
* Avarekalu -- Called Hyacinth beans in English, Avarekalu is a winter speciality in the south that is added to sambhar, saagu, rotis, etc. Bangalore is famed for its Averakalu mela during the winter months, where you can find these beans in dosas, Pani puri and even Jalebis! Thronged by crowds from all over the city, the food fest is a gourmand's delight.
Called Hyacinth beans in English, Avarekalu is a winter speciality in the south that is added to sambhar, saagu, rotis, etc. | Wikimedia Commons
* Amla -- The Indian gooseberry is a common winter fruit found through the country. High in Vitamin C, it is known to be immunity building and extremely beneficial for the skin and hair. There are multiple ways to eat Amla -- it is pickled, made into a fruit preserve called as Murraba or even eaten by sprinkling salt over it.
The Indian gooseberry is a common winter fruit found through the country. | Pixabay
(Article originally published on IANSlife) (IANS/ MBI)
Keywords: winter, Sanjeev Kapoor, chef, Indian gooseberry, Sweet Potato, Radish pods