Friday January 24, 2020

New Way To Treat Pancreatic Cancer is Here: Researchers

The Decoded mechanism acts efficiently in other types of cancer resistant to current therapies

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Pancreatic Cancer
Researchers have now harnessed information to efficiently eradicate human Pancreatic Cancer cells in xenografts. Pixabay

Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells.

The study, published in the journal Oncotarget, was conducted with xenografts — transplantations of human pancreatic cancer into immunocompromised mice.

The treatment reduced the number of cancer cells by 90 per cent in the developed tumors a month after being administered.

“In research published in 2017, we discovered a mechanism that causes the self-destruction of human cancer cells during their duplication (mitosis) without affecting normal cells,” said study researcher Malka Cohen-Armon from Tel Aviv University in Israel.

“We have now harnessed this information to efficiently eradicate human pancreatic cancer cells in xenografts. The current results were obtained using a small molecule that evokes this self-destruction mechanism in a variety of human cancer cells,” Cohen-Armon added.

According to the researchers, the mice were treated with a molecule called PJ34, which is permeable in the cell membrane but affects human cancer cells exclusively. This joint research and discovery by carried by the esteemed physician, Dr. Talia Golan M.D in collaboration with TAU Sackler School of Medicine and its professor, Malka Cohen-Armon. Sheba Medical Center is recognised as one of the top 10 hospitals worldwide by Newsweek.

This molecule causes an anomaly during the duplication of human cancer cells, provoking their rapid cell death.
Thus, cell multiplication itself resulted in cell death in the treated cancer cells.

Pancreatic Cancer
Pancreatic Cancer is resistant to all current treatments. Patients have extremely poor chances of surviving for five years after being diagnosed but a new study found that a small molecule has the ability to induce the self-destruction of pancreatic cancer cells. Pixabay

A month after being injected with PJ34 daily for 14 days, the pancreatic cancer cells in the tumuors of the treated mice experienced a relative drop of 90 per cent. In one mouse, the tumuor completely disappeared.

“It is important to note that no adverse effects were observed, and there were no changes in the weight gain of the mice, nor in their behaviour,” Cohen-Armon added.

ALSO READ: Protein Deficiency Ordinary Among Indians: Experts

This mechanism acts efficiently in other types of cancer resistant to current therapies.

The molecule PJ34 is being tested in pre-clinical trials according to FDA regulations before clinical trials begin, the study said. (IANS)

  • Ittyerah Tholath

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Snake is the Most Probable Wildlife Animal Reservoir of Novel Coronavirus: Study

Snake was one of the animals being sold in Wuhan's Huanan Seafood Wholesale Market before its closure.

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Snake is the most probable wildlife animal reservoir for the novel coronavirus that had caused 17 deaths in central China's Hubei Province. (Representational Image). Pixabay

A study published on Wednesday in the Journal of Medical Virology showed that snake is the most probable wildlife animal reservoir for the novel coronavirus that had caused 17 deaths in central China’s Hubei Province.

Scientists from Peking University Health Science Center School of Basic Medical Sciences, the First affiliated Hospital of Guangxi University of Chinese Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Ningbo University’s School of Medicine, and Wuhan University of Bioengineering carried out a comprehensive analysis on the existing sequences of the newly identified coronavirus, the Xinhua news agency reported.

They used a method called “relative synonymous codon usage” (RSCU) bias to compare RNA sequences of different animal species.

Snake was one of the animals being sold in Wuhan’s Huanan Seafood Wholesale Market before its closure. The market is believed to be related to most of the infected cases.

Snake
Snake was one of the animals being sold in Wuhan’s Huanan Seafood Wholesale Market before its closure. The market is believed to be related to most of the infected cases. Pixabay

Results obtained from the analyses suggested that the new virus 2019-nCoV appeared to be a recombinant virus between the bat coronavirus and an origin-unknown coronavirus.

The recombination occurred within the viral spike glycoprotein, which recognizes cell surface receptor. Additionally, their findings suggested that snake is the most probable wildlife animal reservoir for the 2019-nCoV based on its RSCU bias resembling snake compared to other animals.

Taken together, the research results suggested that homologous recombination within the spike glycoprotein may contribute to cross-species transmission from snake to humans.

Also Read- New Locust Swarms Threaten Agriculture in Ethiopia

Glycoprotein is a group of conjugated proteins containing small amounts of carbohydrates.

Chinese health authorities have posted the full genome of 2019-nCoV in the genetic sequence database of U.S. National Institutes of Health and the Global Initiative on Sharing All Influenza Data, according to U.S. Centers for Disease Control and Prevention (CDC). (IANS)