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At a time when nearly 70 drugs and experimental cocktails are being examined to treat the novel coronavirus (COVID-19), the World Health Organisation (WHO) has announced a global trial called ‘SOLIDARITY to find out if any drug can actually treat infections with the new coronavirus.
The trial, which could include many thousands of patients in dozens of countries, has been designed to be as simple as possible so that even hospitals overwhelmed by an onslaught of COVID-19 patients can participate, according to the prestigious journal Science.
Scientists have suggested dozens of existing compounds for testing but WHO is focusing on what it says are the four most promising therapies. These are “an experimental antiviral compound called remdesivir; the malaria medications chloroquine and hydroxychloroquine; a combination of two HIV drugs, lopinavir and ritonavir; and that same combination plus interferon-beta, an immune system messenger that can help cripple viruses,” said the article in the journal of the American Association for the Advancement of Science (AAAS).
Originally developed by Gilead to combat Ebola and related viruses, remdesivir shuts down viral replication by inhibiting a key viral enzyme, the RNA-dependent RNA polymerase. The first COVID-19 patient diagnosed in the US — a young man in Snohomish County, Washington state — was given remdesivir when his condition worsened and he improved the next day, according to a case report in the New England Journal of Medicine (NEJM).
A Californian patient who received remdesivir recovered as well. When it comes to Chloroquine and hydroxychloroquine, the “WHO scientific panel designing SOLIDARITY had originally decided to leave the duo out of the trial but had a change of heart at a meeting in Geneva on 13 March, because the drugs “received significant attention” in many countries.”
The available data are thin and results from COVID-19 patients are murky. Chinese researchers who report treating more than 100 patients with chloroquine touted its benefits in a letter in BioScience, but the data underlying the claim have not been published. All in all, more than 20 COVID-19 studies in China used chloroquine or hydroxychloroquine, WHO notes, but their results have been hard to come by.
“WHO is engaging with Chinese colleagues at the mission in Geneva and have received assurances of improved collaboration; however, no data has been shared regarding the chloroquine studies.” Researchers in France have published a study in which they treated 20 COVID-19 patients with hydroxychloroquine. They concluded that the drug significantly reduced viral load in nasal swabs. But it was not a randomized controlled trial and it didn’t report clinical outcomes such as deaths.
“Hydroxychloroquine in particular might do more harm than good. The drug has a variety of side effects and can in rare cases harm the heart,” said the Science article. Ritonavir/lopinavir combination drug, sold under the brand name Kaletra, was approved in the US in 2000 to treat HIV infections.
The first trial with COVD-19 was not encouraging, however. Doctors in Wuhan, China, gave 199 patients two pills of lopinavir/ritonavir twice a day plus standard care, or standard care alone.
There was no significant difference between the groups, they reported in the New England Journal of Medicine (NEJM) on March 15. “But the authors caution that patients were very ill — more than a fifth of them died — and so the treatment may have been given too late to help.”
Ritonavir/lopinavir+interferon beta is an another option. A combination of the three drugs is now being tested in MERS patients in Saudi-Arabia in the first randomized controlled trial for that disease. (IANS)
London (CNN)- At five o'clock in the morning, the esteemed 86-year-old astrophysicist Jim Peebles was woken suddenly by the telephone ringing."In previous experience, the only phone calls at that time of night are bad news," he said. This one was great news. "The opening sentence from the caller was: 'The Nobel committee has voted to award you the Nobel Prize in Physics. Do you accept?'" Peebles recalled. The wording threw him. Who wouldn't accept a Nobel Prize? "You know the Bob Dylan fiasco?" he said during a phone interview with CNN. "That might have put the wind up them."The "fiasco" Peebles mentions refers to the 2016 Nobel Prize in Literature, which was controversially given to an utterly unimpressed Dylan.Aside from being ever-presents on college campuses in the 1960s, little connects Peebles, an expert in theoretical cosmology, with Dylan. But one of the starkest contrasts might lie in their reactions to winning a Nobel -- and the songwriter is far from the only laureate whose crowning turned out to be an awkward affair.
The five committees are notoriously secretive, fiercely shielding their choices from the outside world -- including the laureates themselves, who are told of their victories just minutes before they are announced to the public.
Jim Peebles speaking at the Nobel Prize banquet in 2019 Image credit: CNN
That tight-lipped mantra can lead to some heartening surprises, as it did for Benjamin List -- the co-winner of this year's Nobel Prize in Chemistry -- who was having coffee with his wife when he received the news.
"Sweden appears on my phone, and I look at her, she looks at me and I run out of the coffee shop to the street ... you know, that was amazing. It was very special. I will never forget," he told reporters on Wednesday after his victory was announced.It can also be far less celebratory. "I was lying in bed, and my wife woke up and heard my phone buzzing. And she yelled at me because my phone was waking her up," David MacMillan, who shared the prize with List, told BBC Radio 4 on Thursday."100% [I] missed the call. Classic Scottish person. I [didn't] believe this is happening, so I went back to bed," he added -- likely the most relatable sentence ever uttered by an expert in chiral imidazolidinone catalysts.
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And for some, the sudden ascension to Nobel laureate is an unwanted intrusion altogether. "Oh Christ," British-Zimbabwean author Doris Lessing said when reporters arrived outside her house to inform her she had won the Nobel Prize in Literature in 2007. "I'm sure you'd like some uplifting remarks of some kind. "It's a wonderful thing," Reinhard Genzel, an astrophysicist who won last year's Nobel Prize in Physics, told CNN of his win and the months since. "But it's a chore as well."
What it's like to win a Nobel PrizeFew Nobel winners can honestly say their lives weren't changed when they received the phone call.As long as they believe it, that is. "These days you get these cold calls, and I thought this is another one of them," Abdulrazak Gurnah, the winner of this year's literature prize, told the BBC on Thursday."This guy said, 'Hello, you have won the Nobel Prize for Literature,' And I said, 'come on, get out of here. Leave me alone,'" Gurnah said. "He talked me out of that, and gradually persuaded me."Winners often can't be contacted at all, leaving them to find out about their wins from the news, their family, or even their next-door neighbors.
Nobel Peace Prize winners Ressa and Muratov Image source: CNNEconomist Paul Milgrom was woken in the middle of the night in California by his colleague Robert Wilson banging on his front door. "Paul, it's Bob Wilson. You've won the Nobel Prize," he shouted into the intercom. "Yeah, I have? Wow," an utterly confused Milgrom responded, in an exchange captured by a doorbell camera.
Genzel's phone call came while he was in a Zoom meeting with colleagues last October. "I had absolutely no inkling," he said. "I thought, my God ... obviously this is a fantasy."
The committee's secretary told him he "couldn't say anything for 15 or 20 minutes," so Genzel tried his best to keep the news to himself. "I walked over to our meeting room ... (my colleagues) told me afterwards I was stumbling in there, slightly gazed, telling them to switch on the TV," he said.Malala Yousafzai, the youngest Nobel winner at 17, was midway through a chemistry lesson at a school in Birmingham, England, when a teacher interrupted to tell her she had won, she told Reuters.She later told Vogue that she modestly left the achievement off her university applications, because she "felt a bit embarrassed." But there are occasions, too, where the winner isn't quite as thrilled as the Nobel committee might imagine.
Dylan and Ernest Hemingway both skipped the Nobels' annual banquet; the latter made a point of telling the Swedish Academy that he had "no facility for speech making and no command of oratory." But arguably it was Lessing who had the most memorable reaction. She learned of her win as she stepped out of a taxi on the way back from the grocery store. "Have you heard the news? You've won the Nobel Prize for Literature!" an enthusiastic reporter told her. Her eyes rolled back in her head before the journalist had even finished his sentence. Lessing -- accompanied by a male acquaintance who stood next to her, bemused, his arm in a sling and a single artichoke in his hand -- was clearly more interested in collecting her shopping than talking to the world's media.
Also read: Abdulrazak Gurnah- The New Nobel Laureate
Asked how she felt, she expressed little enthusiasm: "Look, I've won all the prizes in Europe, every bloody one."
"Am I supposed to get excited, or elated, or what?" she remarked. "One can't get more excited than one gets, you know?"
'I was treated like a rock star'
As soon as Genzel's win was announced last year, his face was on televisions around the world. The announcement of a Nobel Prize winner makes the front pages of newspapers and websites almost everywhere, throwing a sudden spotlight on little-known scientists and their complex research. "Once the announcement is made, you lose your identity within half an hour," Genzel said. "The telephone rings all the time. "Peebles had a similar experience just minutes after his early morning phone call. "When I returned to bed my wife said, 'What was that about?' I said 'Nobel Prize,' and she said: Oh God." Within minutes, the couple had a photographer outside their door. Genzel suddenly found himself answering questions about politics on late-night German TV, angering some of his friends with his responses. Peebles, meanwhile, spent much of the day looking through emails from every corner of the world: "Please come visit us, please read my manuscript..."
Reinhard Genzel posing with his medal Image source: CNN
"It's one thing to say that the Nobel Prizes attract attention. It's another to experience it," he said. Sometimes, personal relationships change. "There is of course a lot of envy, from some colleagues -- many people who are close to me in the same field might very well say, 'Why did he get it?'" said Genzel. But before the Covid-19 pandemic scuppered plans for two years in a row, winners were also treated to a gala in Stockholm. "I was treated like a rock star ... I experienced what I expect rock stars to experience," Peebles said of his banquet in 2019. "It's a wonderful honor." "My attache had an almost endless list of things to do," he added. "'Now you must meet these influential people. Now you must go to a news conference. Now we will have dinner with some important people. And on and on.' "Genzel missed out on the festivities last year, but he enjoyed a low-key affair in Germany. "The governor of Bavaria offered us his residence, (and) we had a fairly nice event with the Swedish ambassador," he said. Two years on, CNN asked Peebles whether his email inbox has finally receded to pre-Nobel volumes. "I'd have to look at the data on that," he responded, ever the empiricist. But for both men and many other laureates, the most exciting part of the Nobel experience is simply that it gets people talking about science and culture.
"I find it almost a necessity to tell the public at large that there is truth, there is absolute truth," Genzel said. "What I hope is understood is the importance of the Nobel Prize in making people aware of the importance of curiosity-driven science or arts," he said. "I think it must be unique."
(This article is originally written by Bob Picheta)
Keywords: Nobel Prize, Reactions, Laureates
Married Hindu women are recognised by a red streak of vermillion in the middle of their foreheads. This is traditionally called 'sindoor', which is derived from the Sanskrit word sindura, meaning 'red lead.'. Sindoor is traditionally powdered turmeric and lime, sometimes red saffron, or red sandalwood. It is also called vermilion, or Kumkum.
Sindoor is traditionally powdered turmeric and lime, sometimes red saffron, or red sandalwood. It is also called vermilion, or Kumkum. Image source: Photo by Gayathri Malhotra on Unsplash
The origin of the practise of wearing sindoor is ambiguous, but historical records from the Harappan civilisation show that women wore sindoor as a sign of being married. Today's generation considers the wearing of sindoor an outdated and patriarchal ritual. However, there is still a large population of women who uphold the ritual of adorning their foreheads with vermilion every day.
Sindoor implies the longevity of a woman's marriage to her husband in the Hindu tradition. The longer the streak, the longer her husband's life is believed to be. Women wear it for the first time on their wedding day, when the husband applies it during the ceremony. As long as he remains alive, the red streak that fills the woman's maang, or hair partition, symbolises her fruitful married life.
When the finger used to apply the sindoor touches the pituitary gland every time, it arouses affection in a woman for her husband. Image credit: Photo by Amish Thakkar on Unsplash
The components of the red powder are believed to improve the sexual energy of the woman. When the finger used to apply the sindoor touches the pituitary gland every time, it arouses affection in a woman for her husband. The mixture that she wears on her head controls her blood pressure and activates her sexual drive.
These days, feminists do not take very lightly to the practice of wearing sindoor, as they view it as a sign of patriarchal dominance. They do not like being branded as 'belonging to a man'. They prefer to wear it as a style statement because it enhances beauty. Fashion designers have recently commissioned models to sport sindoor on the runway. New age feminists are making bids to allow widows and single women to adorn their foreheads with the vermilion streak.
Keywords: Sindoor, Marriage, Symbol, Women, Patriarchy
Actress Urvashi Rautela has recently announced the name of her next film which is titled 'Dil Hai Gray'. It's a Hindi remake of Tamil film 'Thiruttu Payale 2'. Urvashi Rautela will be seen alongside Vineet Kumar Singh and Akshay Oberoi.
Urvashi shares: "I am excited to announce the title of my next film 'Dil Hai Gray' on the auspicious day of Vijaya Dashami. The film is very close to my heart and it was lovely working with director Susi Ganeshan sir, producer M Ramesh Reddy sir, and my co-stars Vineet Kumar Singh and Akshay Oberoi. "
"The film has created a massive response in the south industry and I am very positive about the story that it will be also be loved by the audience here. I hope my fans would bless us with their love and support. Super excited to watch my film on the big screen after a long time," she concludes. (IANS/ MBI)
Keywords: urvashi rautela, movies, bollywood, south, remake, film