Thursday April 2, 2020

Here’s why You Should Drink Orange Juice Everyday

Drink orange juice to cut obesity risk and better heart health

0
//
Orange juice
Drinking two-and-a-half glasses of orange juice a day could reverse obesity and reduce the risk of heart disease and diabetes. Lifetime Stock

Want to live a healthy and long life? Please take note. Researchers have found that drinking two-and-a-half glasses of orange juice a day could reverse obesity and reduce the risk of heart disease and diabetes.

According to the findings, published in the Journal of Lipid Research, the researchers are studying a molecule found in sweet oranges and tangerines called nobiletin, which they have shown to drastically reduce obesity and reverse its negative side-effects.

“We went on to show that we can also intervene with nobiletin. We’ve shown that in mice that already have all the negative symptoms of obesity, we can use nobelitin to reverse those symptoms, and even start to regress plaque build-up in the arteries, known as atherosclerosis,” said study researcher Murray Huff from Western University in Canada.

The research team demonstrated that mice fed a high-fat, high-cholesterol diet that were also given nobiletin were noticeably leaner and had reduced levels of insulin resistance and blood fats compared to mice that were fed a high-fat, high-cholesterol diet alone.

Orange juice
Orange juice is rich in Vitamin C and is considered to be very healthy. Lifetime Stock

However, they still haven’t been able to pinpoint exactly how nobiletin works. According to the study, the researchers hypothesized that the molecule was likely acting on the pathway that regulates how fat is handled in the body.

Called AMP Kinase, this regulator turns on the machinery in the body that burns fats to create energy, and it also blocks the manufacture of fats. However, when the researchers studied nobiletin’s effects on mice that had been genetically modified to remove AMP Kinase, the effects were the same.

“This result told us that nobiletin is not acting on AMP Kinase, and is bypassing this major regulator of how fat is used in the body. What it still leaves us with is the question – how is nobiletin doing this?” Huff said. According to the researchers, this result is still clinically important because it shows that nobiletin won’t interfere with other drugs that act on the AMP Kinase system.

Also Read- Malawi Parliament Allows Cultivation of Cannabis for Medicinal Purposes

The current therapeutics for diabetes like metformin, for example, work through this pathway, the researchers said. The next step is to move these studies into humans to determine if nobiletin has the same positive metabolic effects in human trials.

“Obesity and its resulting metabolic syndromes are a huge burden to our health care system, and we have very few interventions that have been shown to work effectively, we need to continue this emphasis on the discovery of new therapeutics,” Huff concluded. (IANS)

Next Story

Can AI Predict Diabetes Accurately? Find it Out Here

AI to predict future diabetes cases with 94% accuracy

0
AI diabetes
Researchers have revealed that with the help of artificial intelligence (AI) their trained computer model predicted the future incidence of diabetes. Pixabay

Researchers have revealed that with the help of artificial intelligence (AI) their trained computer model predicted the future incidence of diabetes with an overall accuracy of 94.9 per cent.

Artificial intelligence (AI) is the development of computer systems able to perform tasks that normally require human intelligence. Diabetes is linked to increased risks of severe health problems, including heart disease and cancer. Preventing diabetes is essential to reduce the risk of illness and death.

“Currently, we do not have sufficient methods for predicting which generally healthy individuals will develop diabetes,” said study lead author Akihiro Nomura from Kanazawa University in Japan. “Using machine learning, it could be possible to precisely identify high-risk groups of future diabetes patients better than using existing risk scores,” Nomura added.

For the findings, published in the Journal of the Endocrine Society, the researchers investigated the use of a type of artificial intelligence called machine learning in diagnosing diabetes.

AI diabetes
Artificial intelligence (AI) is the development of computer systems able to perform tasks that normally require human intelligence. Pixabay

Machine learning is a type of AI that enables computers to learn without being explicitly programmed. The research team analysed 509,153 nationwide annual health checkup records from 139,225 participants from 2008 to 2018 in the city of Kanazawa in Japan.

Among them, 65,505 participants without diabetes were included. The data included physical exams, blood and urine tests and participant questionnaires.

Patients without diabetes at the beginning of the study who underwent more than two annual health checkups during this period were included.

New cases of diabetes were recorded during patients’ checkups, the researchers said.

Also Read- Here are the Health Benefits of Fermentation

The researchers identified a total of 4,696 new diabetes patients (7.2 per cent) in the study period. Their computer model predicted the future incidence of diabetes with an overall accuracy of 94.9 per cent.

According to the authors, the next plan is to perform clinical trials to assess the effectiveness of using statins to treat groups of patients identified by the machine learning model as being at high risk of developing diabetes. (IANS)