Wednesday September 26, 2018

Why migraines are more common among women

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New York, Feb 8 : Females are more vulnerable to certain stress-related and allergic diseases such as migraines because of distinct differences found in mast cells, a type of white blood cell that is part of the immune system, says a study.

Mast cells are an important category of immune cells because they play a key role in stress-related health issues that are typically more common in women such as allergic disorders, auto-immune diseases, migraines and irritable bowel syndrome, or IBS.

“Over 8,000 differentially expressed genes were found in female mast cells compared to male mast cells,” said lead researcher Adam Moeser, Associate Professor at Michigan State University in the US.

“While male and female mast cells have the same sets of genes on their chromosomes, with the exception of the XY sex chromosomes, the way the genes act vary immensely between the sexes,” Moeser noted.

A further in-depth analysis of the genes within the RNA genome — a primary building block in all forms of life — revealed an increase in activity that is linked to the production and storage of inflammatory substances, according to the study published in the journal Biology of Sex Differences.

These substances can create a more aggressive response in the body and result in disease.

“This could explain why women, or men, are more or less vulnerable to certain types of diseases,” Moeser said.

With this new understanding of how different genes act, scientists could eventually start developing new sex-specific treatments that target these immune cells and stop the onset of disease, Moeser said. (IANS)

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Paralyzed Patients Start Walking Following A New Treatment

the researchers say this is not a cure for paralysis, and caution that it may not work on every patient. They say more study is needed.

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A wheelchair sits in the viewing area at a golf course, June 19, 2017. Medical researchers are working to stimulate the spinal cord to allow paralyzed patients to stand and walk.. VOA

U.S. researchers are reporting progress in helping those paralyzed by spinal cord injuries to stand, and even to take steps.

Two teams of medical researchers working separately say an electrical implant that stimulates the spinal cord allowed three paralyzed patients to stand and move forward while they held on to a walker or were supported from the back.

One patient was able to walk the length of a football field.

“Recovery can happen if you have the right circumstances,” University of Louisville professor Susan Harkema said, adding that the spinal cord can “relearn to do things.”

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Bionic exoskeleton helps wheelchair users stand and walk. Flickr

Experts say that a damaged spinal cord leaves the brain unable to send messages to the nerves that activate the muscles.

The researchers believe those nerves are still alive, but are asleep.

Stimulating them with electricity, along with intense rehabilitation, can wake up those sleeping nerves and enable them to receive commands again.

Other earlier treatments using electricity allowed patients to stand and move their toes, but not walk.

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Experts say that a damaged spinal cord leaves the brain unable to send messages to the nerves that activate the muscles.

But the researchers say this is not a cure for paralysis, and caution that it may not work on every patient. They say more study is needed.

Also Read: HP Launches Game Changing 3D Printing Technology

Reports on the new therapy appear in the New England Journal of Medicine and the journal Nature Medicine. (VOA)

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