Wednesday November 21, 2018

Why migraines are more common among women

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New York, Feb 8 : Females are more vulnerable to certain stress-related and allergic diseases such as migraines because of distinct differences found in mast cells, a type of white blood cell that is part of the immune system, says a study.

Mast cells are an important category of immune cells because they play a key role in stress-related health issues that are typically more common in women such as allergic disorders, auto-immune diseases, migraines and irritable bowel syndrome, or IBS.

“Over 8,000 differentially expressed genes were found in female mast cells compared to male mast cells,” said lead researcher Adam Moeser, Associate Professor at Michigan State University in the US.

“While male and female mast cells have the same sets of genes on their chromosomes, with the exception of the XY sex chromosomes, the way the genes act vary immensely between the sexes,” Moeser noted.

A further in-depth analysis of the genes within the RNA genome — a primary building block in all forms of life — revealed an increase in activity that is linked to the production and storage of inflammatory substances, according to the study published in the journal Biology of Sex Differences.

These substances can create a more aggressive response in the body and result in disease.

“This could explain why women, or men, are more or less vulnerable to certain types of diseases,” Moeser said.

With this new understanding of how different genes act, scientists could eventually start developing new sex-specific treatments that target these immune cells and stop the onset of disease, Moeser said. (IANS)

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Growth Hormone Deficiency May Also Hit Healthy Children

Since he started getting these injections two years ago, Spencer has grown about 15 centimeters.

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FILE - UNICEF staff measure a girl's height to see if she is stunted in a village health clinic of South Hamgyong province, North Korea. VOA

Most healthy children between the ages of four and 10 grow about five centimeters (two inches) a year. So, one family knew something was wrong when their son fit into the same clothes, season after season. Doctors were able to get him growing once again after testing for a growth hormone.

Eleven year-old Spencer Baehman is passionate about baseball.

“My goal is to play college baseball,” Spencer said.

There was only one problem. Spencer was the shortest player on his team. It didn’t stop him from playing, but the height difference was noticeable. And it made Spencer feel different.

“I want to be as tall as these kids,” Spencer said.

At first, Spencer’s parents thought their son was just small, but gradually, they suspected something was wrong. His mom, Stephanie Baehman, became worried.

“It really set in one year coming out of winter into spring when he got out his cleats for spring baseball and he put them on, and they fit. And they never should have fit. Those were from the spring prior,” Baehman said.

Spencer’s parents set up an appointment with Dr. Bert Bachrach, the chief of pediatric endocrinology at University of Missouri Health Care. Nurses measured Spencer’s height.

After careful testing, Dr. Bachrach determined a growth hormone deficiency was causing Spencer’s growth failure. Hormones are basically chemicals that send messages from one cell to another.

“Growth hormone just doesn’t affect your growth, it affects your muscle mass and fat distribution, so that affects your cholesterol, that affects you overall, it also affects your overall sense of wellbeing,” Bachrach said.

Young Kids learning
Young Kids learning. pixabay

Growth hormone insufficiency is a disorder involving the pituitary gland which is a small, pea-sized gland located at the base of the brain. It’s this gland that produces human growth hormone, among others.

Also Read: Poor Aerobic Fitness Increases Risk of Diabetes in Kids

Every day, Spencer’s mother gives him a daily hormone injection. Since he started getting these injections two years ago, Spencer has grown about 15 centimeters (six inches). But just in case he doesn’t grow tall, he has a reminder written in each of his baseball caps.

“It says HDMH, which means height doesn’t measure heart,” Spencer read.

And heart is something Spencer has plenty of. (VOA)