Get subscribed to our newsletter
Get interesting updates to your email inbox.
Now you know why your wife keeps her blood pressure down even when you keep on sulking during a quarrel at home. According to an interesting research, females have an innate ability to increase levels of anti-inflammatory T cells to keep their blood pressure down.
Called Tregs, the cells are known to help protect us from an excessive immune response, and are naturally associated with lower blood pressures and less organ damage.
Females, at least before menopause, tend to have lower blood pressures than males.
Follow NewsGram on Facebook to stay updated.
“We think, based on studies in this and other models, that the ability of the female to maintain or upregulate those T regulatory cells is critical to their ability to maintain a lower pressure,” said Dr. Jennifer C. Sullivan, professor in the Department of Physiology at the Medical College of Georgia at Augusta University.
In the face of a multipronged front to drive blood pressure up, including a high-salt diet, females are better able to keep their pressure down by increasing levels of a T cell that selectively dials back inflammation.
The T cell’s levels are known to increase to help maintain a healthy pregnancy, for example, so the immune system does not attack the fetus, which has DNA from both parents.
“This is just a different challenge, but we are using those same protective pathways to do something else good for us,” said Sullivan.
Sullivan’s work, published in the journal Hypertension, supports the hypothesis that females rely heavily on Tregs for blood pressure control and this mechanism accounts for at least one of the sex differences in that control.
“It’s a compensatory response to an increase in blood pressure to help the overall cardiovascular impact,” Sullivan said of this innate ability that could provide a promising new hypertension treatment strategy, particularly for women.
Sullivan suspects males and females likely make similar numbers of Tregs — they have found similar numbers in the spleen, for example — but differences may be in the recruitment and proliferation to organs key to blood pressure control like the kidneys, one reason she wanted to look specifically at Treg levels there.
Both sexes actually experienced increases in pro-inflammatory T cells, which contribute to infection fighting.
In rats, blood pressure increased significantly in both sexes by day two, but by the end of 21 days of treatment, male blood pressures were significantly higher.
And, females experienced significantly more of the blood pressure-mitigating Tregs along with their lower pressures, the scientists report.
The fact that decreasing Tregs in males did not affect blood pressure may indicate that male blood pressure is not as dependent on this mechanism during normal conditions.
However the clear impact in females supports the hypothesis that females are “highly dependent” on Tregs to maintain their pressure.
The hormone DOCA, or deoxycorticosterone acetate, prompts the kidneys to hold onto both more sodium and water, so there is a higher fluid volume in the blood vessels, which drives up blood pressure.
Then, as with some humans, a high-salt diet magnifies the problem and so does the removal of a single kidney.
This DOCA-salt model is a commonly used hypertension model, which provides scientists a good window for when hypertension sets in.
“If we can better understand how and why females are increasing their Tregs that could lead to therapies, potentially for both sexes, to also avoid or treat high-inflammation conditions like autoimmune and cardiovascular disease,” Sullivan noted. (IANS)
Canadian researchers have discovered an overlooked gene that plays a major role in the development of antibodies, which help the immune system recognize and fight viruses including SARS-CoV-2, bacteria and other causes of infectious disease. The gene -- FAM72A -- facilitates production of high-quality antibodies by enabling the effect of an enzyme called AID (for Activation-Induced Deaminase), the researchers showed.
Immunologists have known for two decades that AID is essential to produce antibodies capable of clearing infections, but the full mechanism of its effect has remained unknown. "Our findings answer the long-standing question of how AID does its work," said Alberto Martin, a professor of immunology at the University of Toronto's Temerty Faculty of Medicine. "FAM72A helps AID to promote mutations in antibody genes that are essential for the development of effective antibodies," he added.
Genetic mutations that lead to lasting changes in DNA occur through a process called mutagenesis. | Pixabay
Genetic mutations that lead to lasting changes in DNA occur through a process called mutagenesis. In the context of antibody development, mutagenesis unfolds largely through the AID-driven mechanisms called somatic hypermutation and class switch recombination -- both of which help antibodies gain the diversity and potency they need to counter a wide range of pathogens.
The results published in the journal Nature will help researchers better understand antibody development broadly, but they also have implications for cancer. Uncontrolled mutagenesis in B cells that produce antibodies is linked to B cell lymphoma, and FAM72A is present at very high levels in other cancers such as gastrointestinal, breast, lung, liver and ovarian cancers.
"Our data show that high levels of FAM72A promote mutations in antibody genes, so increased levels of FAM72A could spur cancer development, progression or drug resistance by increasing mutagenesis,a Martin said. Martin's team is now exploring those possibilities. Intriguingly, unlike other mammals, humans have four gene versions of FAM72A and their roles in cancer and antibody production are still unknown. (IANS/ MBI)
Keywords: researchers, cancer, mutagenesis, antibody, development, antibodies, canada, COVID
Mahanadi Coalfields Limited (MCL), a subsidiary of Coal India will set up a 50 megawatt (MW) solar power plant in Odisha's Sambalpur at a total cost of Rs 301.92 crore, moving steadily towards its goal to achieve carbon neutrality by 2024. MCL has placed a turnkey order to set-up a 50 MW solar power plant with a Chennai-based firm M/s Hild Energy Ltd, which will establish this green energy project within a timeline of 10 months, the MCL said in a statement on Saturday.
This solar plant would cater to the captive power requirement of MCL. The Central PSU had successfully set-up a 2MW solar power plant in Sambalpur in 2014. The company said it has pledged a target of installing 182 MW of solar power by 2024 in order to become a net zero energy company, aligning itself to use cleaner forms of energy for coal production.
The company said it has pledged a target of installing 182 MW of solar power by 2024. | Photo by Mariana Proença on Unsplash
This 50 MW solar power project will reduce CO2 emission by 91,020 tonnes per annum and carbon offsets of around 24,824 tonnes per annum, claimed the MCL. MCL is the leading production subsidiary of Coal India, having mining operations in Angul, Jharsuguda and Sundargarh districts of Odisha. Having achieved the highest ever capital expenditure of Rs 2,419 crore in the financial year 2020-21, the company has coal production and dispatch targets of 163 million tonnes and 182 million tonnes, respectively.
MCL was the coal mining company to introduce environment-friendly surface miner technology, which contributes over 95 per cent in coal production. As another environment-friendly initiative, the company has successfully introduced vertical rippers for blast-less over-burden removal in Hingula and Kaniha opencast projects. (IANS/ MBI)
Keywords: solar plant, carbon neutrality, Odisha, Sambalpur, Coal India, subsidiary, Mahanadi Coalfields Limited, solar energy
As the nation celebrated the 114th birth anniversary of his father - renowned poet Harivansh Rai Bachchan - megastar Amitabh Bachchan remembered his dad as he penned a heartfelt note for him. The actor took to his blog where he poured his heart out and also shared an unseen photo with his father. The image in question is from Big B's wedding in 1973, where the two are caught in a sweet moment as they look at each other.
Amitabh Bachchan wrote on his blog,
"My Father , my all .. November 27th his birth in the year 1907 .. Which makes it his 114th Anniversary .. He is in the heavens, with my Mother and they celebrate .. as do we , in thought word and deed .. (sic). But first."
He then posted the picture followed by elaborate paragraphs. The megastar wrote,
"Those rare moments when one would find himself rushing against the winds to prevent the distance between us and to close it down as soon as it can be. The day of my wedding and his expression of fulfilment to not just be in congratulation but instead to be in the face of a belief, a chime, an ultimate season of love and great passion, of the quarries of the fears and conditionings of these deprived gym routines kart ..(sic)". "This could have been unknown for long facilitating years, to give not expected versions and lastly large scale informations of the insides ; but as time passed by, as does now , they explained purposely, the values of education and similarity .. Be in peace and love .. (sic)",
the veteran actor concluded his note. (IANS/ MBI)
Keywords: Amitabh Bachchan, Harivansh Rai Bachchan, actor, blog, birth anniversary, 114th birthday