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Gut hormone FGF15 in mice and its human counterpart FGF19 turn off fat-producing genes in the liver. Pixabay

One key gut hormone released a few hours after eating, turns off fat production by regulating gene expression in the liver and this regulation is abnormal in obesity, according to a new study.

The researchers from the University of Illinois (UI) found that the gut hormone FGF15 in mice and its human counterpart FGF19 turn off fat-producing genes in the liver.


The hormones are released a few hours after eating when the body transitions from feeding to fasting.

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FGF15/19 activates regulatory molecules to enter the nucleus, the center of the cell where DNA is stored and inhibits gene expression, reports Xinhua news agency.

“This gut hormone actually acts as a breaker of insulin action, and specifically inhibits lipogenesis in the liver so that it is tightly regulated,” said UI molecular and integrative physiology Professor Jongsook Kim Kemper in the study published in the journal Nature Communications.

“For example, with the holidays coming up, if you eat some cookies, the body will release insulin, which promotes lipogenesis. If lipogenesis is not reduced later when the body enters the fasting state, excess fat will accumulate in the liver, so the FGF19 hormone puts the brakes on fat production.”


It also could have implications for other diseases such as diabetes or certain cancers, for which obesity is a risk factor. Pixabay

Furthermore, in experiments involving mice with obesity and human patients with nonalcoholic fatty liver disease, the researchers found that the pathway for turning off fat production was dysregulated.

Want to read more in Hindi? Checkout: फ्लू के लिए नई थेरेपी, कर सकती है कोविड-19 से लड़ने में मदद : शोध

The genes that the gut hormone regulates were highly active, the FGF15/19-activated regulatory molecules did not even enter the cell’s nucleus and the suppression markers were not added to the genes.

“This study could be very important for understanding this pathway and investigating how it is abnormal in obesity and nonalcoholic fatty liver disease,” Kemper said.

“It adds to our understanding of obesity, nonalcoholic fatty liver disease, and other metabolic disorders. It also could have implications for other diseases such as diabetes or certain cancers, for which obesity is a risk factor.

ALSO READ: Self-Care Guidelines To Boost Immunity, With Special Reference To Respiratory Health

“Based on this study, we potentially could search for therapeutic treatment options to target this pathway and increase regulatory function.” (IANS)


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Prime Minister Narendra Modi announced that 2022 will be celebrated as the friendship year for India and ASEAN countries

Prime Minister Narendra Modi on Thursday announced that 2022 will be celebrated as the friendship year for India and ASEAN countries as both have completed 30 years of partnership.

The event will coincide with India's celebrations of the 75th year of Independence from the colonial regime, he added.

While participating in the 18th edition of the India-ASEAN Summit, Modi said, "India is committed to deepening its relations with the next presidency, Cambodia and country-coordinator Singapore."

"History is witness to the fact that India and ASEAN have had relations for thousands of years. India-ASEAN relations are reflected in everything, including in our shared values, traditions, languages, scriptures, architecture, culture, food," the Prime Minister noted.

Speaking about the Covid pandemic which engulfed the whole world, he further said that the Covid period was also a test of India-ASEAN friendship. "Our mutual ties in the Covid time will keep strengthening our corporations in future and form a base for goodwill between our people," Modi added.

He further said that the unity and centrality of ASEAN have always been a priority for India and history has witnessed the fact that "we have had ties since thousands of years," he said.

The Prime Minister also said that India's Indo-Pacific Oceans Initiative (IPOI) and ASEAN's Outlook for the Indo-Pacific are the framework for their shared vision and mutual cooperation in the Indo-Pacific region.

During the Summit, the head of the member states will review the progress of India and ASEAN Strategic Partnerships which was signed in 2012. They will also review the progress achieved in the sectors like Covid-19, health, trade and investment, connectivity, education among others, the officials of India's Ministry of External Affairs said. (IANS/JB)

Keywords: India, and ASEAN partnership, COVID-19, India, and ASEAN, India, and history, Indo-Pacific Oceans Initiative.


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