Never miss a story

Get subscribed to our newsletter


×
Jumping genes to help in blood cancer. Pixabay

US scientists have found that transposons, also known as jumping genes, can protect against certain blood cancers and help develop new therapeutic targets. Transposons are DNA sequences that can move, or jump, from one location in the genome to another when activated. These “jumping” genes are a source of genetic mutations responsible for a number of human diseases.

The findings, published in the journal Nature Genetics, can help predict how patients will respond to cancer therapies and find new therapeutic targets for acute myeloid leukemia (AML) — the deadliest type of blood cancer in adults and children. In the study, a team of scientists at the Children’s Medical Center Research Institute (CRI) at the University of Texas Southwestern focussed on a type of transposons known as long interspersed element-1 (L1) retrotransposons.


Follow NewsGram on Instagram to keep yourself updated.

They found that activating L1 can lead to genome instability and, in turn, it can activate a DNA damage response that triggers cell death or eliminates the cell’s ability to replicate itself. When researchers screened human AML cells to identify genes essential for cancer cell survival, they found MPP8 — a known regulator of L1 — to be selectively required by AML cells.

ALSO READ: Blood Cancer Risk Higher Than Expected In Kids

Analyzing human and mouse leukemia cells, they found that MPP8 blocked the copying of L1 sequences in the cells that initiate AML, and when the activity of L1 was turned on, it could impair the growth or survival of AML cells. MPP8 thus suppressed L1 in order to safeguard the cancer cell genome and allow AML-initiating cells to survive and proliferate.

“Our initial finding was a surprise because it’s been long thought that activated transposons promote cancer development by generating genetic mutations. We found it was the opposite for blood cancers, and that decreased L1 activity was associated with worse clinical outcomes and therapy resistance in patients,” said Jian Xu, Associate Professor in the CRI. (IANS/SP)


Popular

Kishu Inu and Dogelon Mars are some of the more popular canine coins in recent months. Their popularity is demonstrated by the vast amount of trading volume that these cryptocurrencies receive.

At the time of writing, Kishu Inu has a trading volume exceeding $10 million and Dogelon Mars has an even larger trading volume that surpasses $30 million.

Keep Reading Show less

HUH Token

It’s here, and it appears that there ain’t nothin’ or no one stopping the skyrocketing force of HUH Token and the release of the long-awaited White Paper is finally here and we’re living for it.

It’s also great to note that Shiba Inu made a triumphant crypto market return this week and the reign of the dog continues though with HUH Token’s White Paper release it could see the ‘Utimeme’ token break out of the atmosphere on its December 6th launch and surpass Shiba Inu for altcoin supremacy.

Keep Reading Show less

HUH Token

HUH Token has been on the lips of crypto lovers for some time now and the much-anticipated White Paper release is here, right now, today!

Not only this but Shiba Inu’s mastery of the altcoin world could be coming to an end on HUH Token’s December 6th release if the aims, goals and technology in the White Paper are anything to go by.

Keep reading... Show less