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Casino games have become very prevalent in today's time.

When most people visualize a casino, they would usually think of one of the megaresorts in Las Vegas—a big resort and complex, flashing with blinking lights, gambling, and fun—however, casinos exist in many sizes. Some casinos are big, but others are small; some are played in a building, and many are played online and are characterized more by the forms of gaming they provide rather than by glamour.

Casino gambling, in reality, refers to games of chance and skill performed at tables, on a computer screen, or machines. As a result, casino games may be found in both large resorts and tiny rooms or even at the comfort of your home. Cards, dice games, domino games, slot machines, and betting gadgets are all available in casinos. By far, the most popular sort of casino activity is gaming machines. They are easy to use and may provide high returns for minimal bets. Slot machines were the very first commercialized casino machines established in 1896 since the player slipped a penny into a slot to begin play.

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Photo by Fusion Medical Animation on Unsplash

In the new study, the team found blood serum from patients in the ICU with diabetes and severe Covid-19 had reduced levels of interferon-beta compared to patients without diabetes.

US researchers have identified an enzyme that may explain the reason why people with diabetes are at especially high risk of developing severe illness or dying from coronavirus infection. The culprit appears to be an enzyme called SETDB2. This same enzyme has been implicated in the non-healing, inflammatory wounds found in people with diabetes. Starting with a mouse model of coronavirus infection, they found that SETDB2 was decreased in immune cells involved in the inflammatory response, called macrophages, of infected mice with diabetes. The same thing was observed in monocyte-macrophages in the blood from people with diabetes and severe Covid-19. "We think we have a reason for why these patients are developing a cytokine storm," said researcher W. James Melvin from University of Michigan.

In the mouse and human models, the team found that as SETDB2 went down, inflammation went up. In addition, a pathway known as JAK1/STAT3 was found to regulate SETDB2 in macrophages during coronavirus infection. Taken together, the results point to a potential therapeutic pathway. Further, previous findings demonstrated that interferon -- a cytokine important for viral immunity -- increased SETDB2 in response to wound healing. In the new study, the team found blood serum from patients in the ICU with diabetes and severe Covid-19 had reduced levels of interferon-beta compared to patients without diabetes.

diabetic patients tools "Our research is showing that maybe if we are able to target patients with diabetes with interferon, especially early in their infection, that may actually make a big difference," Melvin said. Photo by on Unsplash

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Photo by Jair Lázaro on Unsplash

Work stress, sleep disorders, and fatigue, regarded as non-traditional risk factors for heart attack and stroke, are rising more steeply amongst women than men, according to a new study presented on Wednesday at the European Stroke Organisation (ESO) Conference. While diabetes, arterial hypertension, raised cholesterol, smoking, obesity, and physical inactivity are recognised modifiable risk factors for cardiovascular disease, recently, it has been noted that non-traditional risk factors such as work pressures and sleep problems can significantly add to cardiovascular risk.

women sitting on sofa in a room Females reported a bigger increase in the non-traditional risk factors for heart attacks and strokes, such as work stress, sleep disorders, and feeling tired and fatigued. Photo by Ben White on Unsplash

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Smoking can lead to Subarachnoid Hemorrhage. Pixabay

Adults who smoke or who are genetically predisposed to smoking behaviors are more likely to experience a serious type of stroke called subarachnoid hemorrhage (SAH), researchers say. The study, published in the journal ‘Stroke’, indicates that those who smoked half a pack to 20 packs of cigarettes a year have a 27 percent increased risk of SAH.

SAH is a type of stroke that occurs when a blood vessel on the surface of the brain ruptures and bleeds into the space between the brain and the skull. It mainly affects middle-aged adults and has high rates of complications and death.

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