Friday January 19, 2018

A new cancer treatment developed by Indian scientists in US

0
//
159
Republish
Reprint

Washington: A team of Indian scientists from the prestigious Massachusetts Institute of Technology and Harvard Medical School has made an important breakthrough by developing a nano-technology which will help monitor the effectiveness of cancer therapy within hours of treatment.

“We have developed a nano-technology, which first delivers an anticancer drug specifically to the tumour, and if the tumour starts dying or regressing, it then starts lighting up the tumour in real time,” said Shiladitya Sengupta, a principal investigator at Massachusetts Institute of Technology’s (MIT) Brigham and Women’s Hospital (BWH).

“This way you can monitor whether a chemotherapy is working or not in real time, and switch the patients to the right drug early on. One doesn’t need to wait for months while taking a toxic chemotherapy only to realise later and after side effects that the drug hasn’t worked,” Mr Sengupta, a co-corresponding author of the breakthrough research published online this week in ‘The Proceedings of the National Academy of Sciences’, told news agency PTI.

The first author of the paper is Ashish Kulkarni, who comes from a small village in Maharashtra. A junior faculty at Harvard, Kulkarni trained as a Chemical Engineer at ICT Mumbai, then did a PhD in chemistry at the University of Cincinnati.

Mr Kulkarni said by using this approach, the cells light up the moment a cancer drug starts working.

“We can determine if a cancer therapy is effective within hours of treatment. Our long-term goal is to find a way to monitor outcomes very early so that we don’t give a chemotherapy drug to patients who are not responding to it,” he said.

“We’ve demonstrated that this technique can help us directly visualise and measure the responsiveness of tumours to both types of drugs,” Mr Kulkarni said.

Other members of the research team are Poornima Rao, Siva Natarajana, Aaron Goldman, Venkata S Sabbisetti, Yashika Khater, Navya Korimerla, Vineethkrishna Chandrasekara and Raghunath A Mashelkar. Except Goldman, all are Indian researchers.

“Current techniques, which rely on measurements of the size or metabolic state of the tumour, are sometimes unable to detect the effectiveness of an immunotherapeutic agent as the volume of the tumour may actually increase as immune cells begin to flood in to attack the tumour,” Mr Kulkarni said.

He said reporter nanoparticles, however, can give “us an accurate read out of whether or not cancer cells are dying”.

The technology developed by the group can be used for monitoring the effectiveness of immunotherapy, a report said.

Using a nanoparticle that delivers a drug and then fluoresces green when cancer cells begin dying, they were able to visualise whether a tumour is resistant or susceptible to a particular treatment much sooner than currently available clinical methods, said a statement from BWH.

Credits: NDTV

 

 

Click here for reuse options!
Copyright 2016 NewsGram

Next Story

India successfully test fires n-capable Agni-V ballistic missile

The missile was earlier tested successfully in 2012, 2013, 2015 and 2016.

0
//
5
Nirbhay
The Defence Research and Development Organisation (DRDO) sources said the Nirbhay missile test was "successful".(Representative image) VOA
  • India successfully tests the Agni-V ballistic missile on Thursday
  • This was the fifth test that missile underwent
  • With this success India is now in ranks with US, UK, China and Russia

India on Thursday successfully test fired its indigenously developed intercontinental surface-to-surface nuclear-capable ballistic missile Agni-V — the most potent and with the longest range in the Agni series – that can reach targets as far as Beijing.

The test took place at the Abdul Kalam Island facility off the Odisha coast. Defence Minister Nirmala Sitharaman tweeted about its success, congratulating its makers DRDO, the armed forces and the defence industry.

You may also like : Ballistic missile Agni-IV test fired as part of user trial

India has many high tech and powerful missiles to its name. Wikimedia Commons
India has many high tech and powerful missiles to its name. Wikimedia Commons

She said the successful test of the 5,000-km-range missile that can carry a one-tonne warhead, was “a major boost to the defence capabilities of our country”.

“The Made in India canistered missile, having three stages of propulsion, was successfully test fired,” she tweeted.

Developed by the Defence Research and Development Organisation (DRDO), the Agni-V is the most advanced version of the Agni series, part of the Integrated Guided Missile Development Programme that started in the 1960s.

The missile was earlier tested successfully in 2012, 2013, 2015 and 2016.

This was the fifth test of the missile and likely to be its first user trial, though there was no official word on it.

India is developing new technologies everyday to strengthen its defence.
India is developing new technologies everyday to strengthen its defence.

Thursday’s test brings the missile closer to its induction in the tri-service Strategic Forces Command.

The missile has a much longer shelf life, with its container being made of special steel that absorbs the blast of the takeoff.

In the canisterised launch, a gas generator inside ejects the missile up to a height of about 30 metres. A motor is then ignited to fire the missile.

Also Read : Nikki Haley says North Korea Could Face Stronger Sanctions due to its 7th Missile test in 2017 .

With this missile, India joins the super-exclusive club of ICBM (missiles with a range of over 5,000-5,500 km) capable countries of the US, Russia, the UK, France and China. IANS