Obesity can lead to breast cancer


By NewsGram Staff Writer

The root cause of many health problems, obesity, can lead to breast cancer as well. A new study has found that obesity results in stiffer breast tissue that promotes the growth of cancer.

Obesity leads to a stiffening of the mesh work material that surrounds fat cells in the breast, called the extracellular matrix, and these bio-mechanical changes create the right conditions for tumours, the findings showed.

ThinkstockPhotos-200302239-001-e1434141030608Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons have remained unclear till now.

“We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening,” said study senior author Claudia Fischbach, associate professor of biomedical engineering at Cornell University in New York.

“But what these findings show is that there are also biophysical changes that are important,” Fischbach noted.
The findings could lead to recognition of stiffer breast cells as a clinical biomarker for breast cancer.

Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.
The findings, published in the journal Science Translational Medicine, suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser fat cells in the breast.

(With inputs from IANS)