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Regular use of a common type of medication such as aspirin and ibuprofen significantly improves the survival rate for a third or more patients with head and neck cancer, a new study has found.
Non-steroidal anti-inflammatory drugs, or NSAIDs, for at least six months provided “markedly prolonged” improved five-year survival rate from 25 per cent to 78 per cent for patients whose cancer contained a specific altered gene, known as PIK3CA, researchers from the University of California-San Francisco (UCSF) reported.
The survival rate for patients whose gene was not altered in their tumour was unaffected by NSAID use.
“Our results suggest that the use of NSAIDs could significantly improve outcomes for not only head and neck cancer patients, but also patients with other cancers that contained the PIK3CA mutation,” said UCSF professor Jennifer R. Grandis.
“The magnitude of the apparent advantage is strong, and could potentially have a positive impact on human health,” Grandis said.
Within head and neck squamous cell carcinoma, PIK3CA is the most commonly altered oncogene, with 34 per cent of all tumours carrying mutations that activate the PIK3CA gene.
In head and neck cancer associated with the human papillomavirus (HPV), PIK3CA is mutated in more than half of tumours.
In the research, published in the Journal of Experimental Medicine, 266 patients from the University of Pittsburgh Medical Center whose tumours were surgically removed were investigated. The majority (84 per cent) smoked and 67 per cent received post-surgery chemotherapy and/or radiotherapy.Median overall survival was 66 months.
Altogether, 75 tumours (28 per cent) in the study had an activating alteration of the PIK3CA gene.
Among the patients who regularly used NSAIDs, 93 per cent used aspirin as a component of the NSAID regiment, and 73 per cent took aspirin exclusively. Most of the regular users started on the aspirin therapy following their head and neck cancer diagnosis.
Through analysis of both cell line and mouse studies, the researchers speculated that NSAIDs likely blocked tumour growth by reducing the production of an inflammatory molecule called prostaglandin E2.
The researchers pointed out that their results need to be corroborated in a prospective trial.
“NSAID use likely confers a statistically and clinically significant advantage in overall survival in PIK3CA-altered head and neck cancer through direct interaction between the PI3K and COX pathways,” said Grandis. (IANS)
The symbol of Swastika is known to signify peace, prosperity, and good fortune in the religious cultures of Eurasia. In fact, this symbol is considered very significant in Hinduism, Buddhism, and Jainism. But, at the same time, it has become one of the most misunderstood religious symbols and has been globally banned in many countries.
The reason why the symbol of Swastika is banned in many countries is because of its association with Adolf Hitler's extreme political ideology, Nazism, as Swastika as its official symbol.
Austria, France, Latvia, Spain, Germany, and Russia are amongst the many countries that have banned the display and use of the Swastika.
Moreover, last week Victoria in Australia is preparing to become the first-ever state to ban the public display of the Swastika. This is a step towards an expansion of anti-vilification laws in the state.
Representation of the Swastika on the flag of Adolf Hitler's Nazi Movement.Photo by Flickr.
Now, we must know and understand what went wrong with this symbol, which is sacred and signifies all-good things.
For a very, very long time, in India, the Swastika is the first emblem that is worshipped or even drawn before any sacred and auspicious ceremonies as this symbol in Sanskrit represents 'well-being'. But, the Swastika lost all its credibility when it was wrongfully used by Adolf Hitler.
In fact, it is believed that if this symbol is worshipped properly, then it gives positive results. But if it is abused, then it gives negative results. So, when Adolf Hitler rotated the Swastika at 45 degrees, it slowly and steadily brought misery not only to Adolf Hitler and his theory of Nazism but also to all the people who were associated with him.
Therefore, in order to give the kind of respect and credibility which the Swastika deserves, World Interfaith Harmony Week which was held in New York in February this year, interfaith groups appealed to the United Nations to recognize and acknowledge the Swastika as an important and peaceful symbol. In fact, they also differentiated it from the Hakenkreuz or "Hooked Cross" of Adolf Hitler.
India celebrated a historic day on August 7, as 23-year-old Neeraj Chopra became the first Indian to win an Olympic gold medal in athletics. In the men's javelin throw event, he achieved his greatest triumph, throwing the javelin 87.58 meters on his second try.
Neeraj Chopra was born on December 24, 1997, in Khandra village in Haryana's Panipat district. He grew up in a Haryanavi family of farmers. He is the brother of two sisters. He graduated from Dayanand Anglo-Vedic College in Chandigarh and is now enrolled in Lovely Professional University in Jalandhar, Punjab, pursuing a Bachelor of Arts degree. Chopra was bullied due to his obesity as a kid, which prompted his father to enroll him in a nearby gym. He then joined a gym in Panipat, where Jaiveer Choudhary, a javelin thrower, noticed his potential and coached him. When the 13-year-old Chopra finished training under Jaiveer for a year, he was enrolled at the Tau Devi Lal Sports Complex in Panchkula, where he began training under coach Naseem Ahmed.
In 2018, he broke the world record in the javelin throw and became India's first-ever gold medalist in the javelin throw. He is also a laureate of the Arjuna Award for 2018. | Wikimedia Commons
Chopra's first international medal came in 2014, as he took home a silver medal at the Youth Olympic Qualification Tournament in Bangkok. In 2015, he set a world record in the junior category of 81.04 meters in the 2015 All India Inter-University Athletics Meet.
Since emerging into the public eye with a historic gold medal at the junior world championships in 2016, he has maintained a high level of performance, setting an Under-20 world record of 86.48m, which still stands. Gold medals in both the 2018 Commonwealth Games and the 2018 Asian Games are among his other accomplishments, including a first-place in the 2017 Asian Championships. In 2018, he broke the world record in the javelin throw and became India's first-ever gold medalist in the javelin throw. He is also a laureate of the Arjuna Award for 2018.
Chopra has also had his share of bad events in life. In 2019, he underwent surgery on the elbow of his right throwing arm, which kept him out of the game for almost a year. However, he returned more robust than ever. In November 2019, he went to South Africa to train from Klaus Bartoneitz. He spent the following year in India training at the NIS Patiala because of the COVID-19 pandemic. He was allowed to go to France with his coach after weeks of trying to get a travel visa.
Neeraj Chopra made history in the 2020 Tokyo Olympics by becoming the first Indian to win a gold medal in athletics. Also, it is worth mentioning that after Abhinav Bindra, Chopra is only the second Indian to win an individual gold medal.
Keywords: Neeraj Chopra, Olympics, Tokyo2020, Gold medal, javelin, India, Haryana
The emergence of the Industrial Revolution in Victorian England brought with it many apprehensions and fears that translated into a new genre in literature: the gothic. Today, the idea of the gothic does not have to much with literature as much as it is associated with fashion.
The Victorians began to wear black more often during the Industrial Revolution to hide the stains of soot on their clothes. Many of the working class were employed in factories. They were newly introduced to technology, the idea of coal as fuel, and the working of machines to serve a certain purpose. This kind of work was hard and messy. Wearing light colours burdened the tired folk when the stubborn stains did not get washed away.
The steam engine was invented to make locomotion easier for the masses, but it brought fear to the people. They had led quiet and simple lives till now, and suddenly their world was infiltrated with loud noises and smoke. Dark places became synonymous with evil deeds and mysteries. It was from this time that horror gained a place in the imaginations of people and artists.
A man sporting gothic clothes and shock coloured hair Image source: wikimedia commons
The gothics of today are those who have held on to these practices. There is no need to fear smoke and noise anymore, but the goths wear black clothes all the time, paint their skin a pale shade, to contrast their clothes, and wear bright shades of red. The traditional gothics decorated themselves with jewellery bearing religious significances, as the belief in Dracula and vampires emerged in the Victorian period. Today, it is a trend to wear studded crosses, or crosses made of black metal either as neck chokers, or earrings.
Modern goths also wear bright monotones to show their patronage of a certain style or order of the goths. They can be seen in neon shades of green, pink, and yellow, often sporting piercings, and matching hair. Their tastes are metallic, and they have an uncanny love for tattoos.
Designers consistently include gothic tastes and styles in their clothing lines to create inclusivity for this subculture. Being gothic, or identifying with them is somewhat a concern even in today's society, and such people are often stigmatised to the extent that it is considered a mental illness associated with the dark arts. The phenomenon is mostly observed in teenagers, and often phases out when they reach adulthood, depending on their sphere of influence.
Keywords: Gothic, Fashion, Victorian, Black, Jewellery