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Washington, Genetic variations and not complying with treatment regimens may account for some failures of an anti-HIV drug to treat and prevent the infection.



The drug Tenofovir, marketed as Viread, is processed differently according to cell locations, the study said.

This is to see if the drug is eventually marketed as a topical gel, it can work differently depending on whether it is applied to the vagina or the rectum.

“Our results suggest that in future, before prescribing tenofovir to a patient, a doctor could order genetic testing and know in advance if it works, and prescribe a different drug if it won’t,” said Namandje Bumpus, associate professor of medicine at the Johns Hopkins University School of Medicine.

In the study described in the journal EBio-Medicine, the team focused on a search for the human enzymes that convert tenofovir from its original form to an activated one that combats HIV.

The team “knocked out” genes for phosphate-adding enzymes one by one, then exposed the tissues’ cells to tenofovir.

They found that the enzyme called pyruvate kinase was different from that which performed the second activation step in the colorectal tissues.

The team sequenced the genes of 142 women who had participated in a clinical trial of tenofovir to look for genetic variations that might have affected the function of the enzyme.

They found 71 such variants, several of which a computer model predicted would make the enzyme ineffective.

Altogether, eight percent of the women had genetic variants that were likely to make them unable to convert tenofovir to its activated form.

“Tenofovir has been shown in trials to be very effective, so when it does not work, researchers and clinicians tend to assume the individual just was not taking the drug as directed,” Bumpus said.

(IANS)


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The Centre will launch a pilot project on the use of indigenously manufactured drones for delivering medicines in the undulating landscape of Jammu and surrounding areas from Saturday

The Centre will launch a pilot project on the use of indigenously manufactured drones for delivering medicines in the undulating landscape of Jammu and surrounding areas from Saturday with a focus on vaccines delivery initially. "This is going to be a pilot project for the area. The drone is developed and manufactured entirely by our scientists," Union Minister for Science & Technology, Dr Jitendra Singh told mediapersons. Singh said he himself will be launching the project at Jammu.

The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL), a constituent of Council of Scientific and Industrial Research (CSIR), an autonomous Society that is headed by the Prime Minister. For now, the delivery would be limited to Covid vaccines and once successful, it would be expanded to be used for regular delivery of medicines in the remote, hilly areas.

drone flying in sky The drone is developed by the scientists at Bengaluru's National Aerospace Laboratories (NAL). | Photo by Jason Blackeye on Unsplash

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According to him Amitabh Bachchan is a great actor in the industry.

Bollywood actor Abhishek Bachchan shares how he feels when people compare him with his father Amitabh Bachchan on the singing reality show 'Sa Re Ga Ma Pa'. He also requests contestant Rajshree Bag to sing a track 'Bahon Mein Chale Aao' featuring his mother Jaya Bachchan.

Abhishek said after looking at the performance of Rajshree, who is often compared with Lata Mangeshkar on the show, that she reminds him of being compared with his father. "Rajshree, whenever I have got the chance to watch the show, I've seen people compare you to Lata didi. It actually reminded me about how people compare me with my father and ask me how I feel about it."

According to him Amitabh Bachchan is a great actor in the industry and this is what he says to everyone making these comparisons. "My answer to them is that there's no greater actor in this film industry than Amitabh Bachchan and if I'm being compared to him, I am sure I must have done something good."

"Similarly, your voice has a different kind of magic like Lata ji and that's why people are comparing your voice with her. I feel you should always take this as a compliment," he concluded. 'Sa Re Ga Ma Pa' airs on Saturday and Sunday on Zee TV. (IANS/ MBI)


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Photo by Aaron Burden on Unsplash

Winters in India have always beckoned for that hot, steaming bowl of tomato and pepper rasam or the mellow, millet based Raab.

By IANSlife

Winters in India have always beckoned for that hot, steaming bowl of tomato and pepper rasam or the mellow, millet based Raab. Certain dishes like sarson ka saag, undhiyu, nimona pulao are winter specialites in the country. Seasonal food has always been an Indian speciality -- we switch our choice in fruits, vegetables, sometimes even grains with the onset of different season. The preference of using specific ingredients during certain climates is visible in our sweets as well. It's common to find local and traditional delicacies made of jaggery, instead of sugar during the winters. Case in point -- the Nolen Gur Rasgulla, a speciality made in Odisha and West Bengal between November to February.

Sarson Ka Saag | Sarson ka saag is traditional Punjabi dish Certain dishes like sarson ka saag, undhiyu, nimona pulao are winter specialites in the country. | Flickr

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