Variations in “ancient” immune cells linked to patients’ survival in cancer

Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS), have achieved breakthroughs in understanding relapse after chemotherapy for a type of cancer known as diffuse large B-cell lymphoma (DLBCL).
“Ancient” immune cells:- Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore [Newswise]
“Ancient” immune cells:- Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore [Newswise]

“Ancient” immune cells:- Researchers from the Cancer Science Institute of Singapore (CSI) at the National University of Singapore (NUS), have achieved breakthroughs in understanding relapse after chemotherapy for a type of cancer known as diffuse large B-cell lymphoma (DLBCL). Led by Assistant Professor Anand Jeyasekharan, the study focused on a specific type of immune cells called "macrophages" found in the cancer's environment, and researchers discovered that variations in these cells are linked to how well patients might recover and survive.

Macrophages are evolutionarily an ancient arm of the immune system and initially evolved to help engulf invading microbes or dying cells. They are frequently noted in cancers as well, but their relevance in lymphoma was unclear.

The essence of the study lay in its deep dive into the diversity of macrophages within the tumour environment of DLBCL. By employing a novel method called Digital Spatial Profiling (DSP) available at CSI’s Microscope and Multiplex Assay (MMA) core facility, the team was able to examine the molecular features of macrophages within a complex mixture of cells in a tumour, identifying subsets of macrophages associated with relapse after chemotherapy. This research showcased the importance of macrophage diversity in understanding and treating this common form of aggressive lymphoma, not only predicting the progression of the disease more accurately but also uncovering potential new therapeutic approaches.

The implications of this research are significant. As macrophages are common in several cancers, similar spatial approaches can be used to evaluate unique patterns in macrophages related to patient outcomes.

Immunotherapy is hailed as the next frontier in cancer treatment, and most current immunotherapeutic approaches target another type of cell – the T cell. The insights gained into macrophage diversity hold the promise of discovering novel drugs and therapeutic methods aimed at modifying the tumour environment in DLBCL and other cancers through tackling macrophages.

Asst Prof Jeyasekharan commented, “Previously, studying immune cells in cancer was conducted in 'bulk', providing only a general overview of their presence in tumours. However, with technological advances now available, our team could examine the molecular features of macrophages with single-cell resolution while preserving their spatial context. We have identified different profiles of these ancient immune cells, which help in predicting the course of the disease more accurately. This step forward opens new possibilities for personalising stratification and treatment for DLBCL.” Newswise/SP

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