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New York: Offering a new explanation for what drives cancer, recent research has shown that cells with cancerous mutations can suddenly find themselves most fit, allowing their population to expand when the tissue ecosystem changes due to ageing, smoking, or other stressors.



Arguing against the commonly held “accumulation of mutations” model of cancer, the study favors a model that depends on evolutionary pressures acting on populations of cells. It, therefore, contends that the ecosystem of a healthy tissue landscape lets healthy cells out compete ones with cancerous mutations.

This new thinking about what drives cancer development may have profound implications for cancer therapy and drug design.

“We have been trying to make drugs that target mutations in cancer cells,” said study senior author James DeGregori, associate director for basic science at University of Colorado Cancer Center in the US.

“But if it is the ecosystem of the body, and not only cancer-causing mutations, that allows the growth of cancer, we should also be prioritizing interventions and lifestyle choices that promote the fitness of healthy cells in order to suppress the emergence of cancer,” said DeGregori.

The proposed model, presented in the journal PNAS, helps to answer a longstanding question in cancer science known as Peto’s Paradox — if cancer is due to random activating mutation, larger animals with more cells should be at greater risk of developing the disease earlier in their lives.

Well, then why do mammals of vastly different sizes and lifespans all seem to develop cancer mostly late in life? The answer to this proposed by researchers is that in addition to activating mutation, cancer may require age-associated changes to the tissue landscape in order for evolution to favor the survival and growth of cancer cells over the competition from healthy cells.


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Photo by Briana Tozour on Unsplash

According to the World Health Organization, in 2020 itself, there were 2.3 million women diagnosed with breast cancer in the world.

Over the last one-and-a-half-year, people have been vocal about both mental and physical health in relationships. Even while miles away from one another, people kept checking on the health and well-being of their loved ones. However, one issue, i.e., breast cancer has been affecting women throughout the world, and it still needs much more focus and attention.

According to the World Health Organization, in 2020 itself, there were 2.3 million women diagnosed with breast cancer in the world. A report published by National Cancer Registry Programme (NCRP) estimates that breast cancer cases are likely to increase by nearly 20 per cent. Throughout the world, the tenth month of the year is recognized as the month of "Pink October" to raise awareness about breast cancer. The month should also be a celebration of encouraging the women in our lives to take the first step in this journey of staying in "Pink of Health". happen, an international dating app, conducted an in-app survey to understand how Indians discuss health issues like breast cancer with their partners. The survey gave a glimpse of whether health issues are impacting the life and relationships of singles.

41 per cent of users are not aware of examinations related to women's health


Forty-one per cent of users shared that they did not encourage the women in their life (mother, sister, friend, etc.) to go for checkups for issues related to health. Sixteen per cent of the respondents confessed that they did not remind women in their life to take examinations for their own health. It is important to note that regular self-examination is likely to detect breast lumps early. One in eight women will develop breast cancer in her lifetime. If it is detected in time, it will be cured in nine out of 10 cases.

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Saudi Aramco engineers and journalists look at the Hawiyah Natural Gas Liquids Recovery Plant, June 28, 2021, in Hawiyah, in the Eastern Province of Saudi Arabia.

One of the world's largest oil producers, Saudi Arabia, announced Saturday it aims to reach "net zero" greenhouse gas emissions by 2060, joining more than 100 countries in a global effort to try and curb man-made climate change.

The announcement, made by Crown Prince Mohammed bin Salman in brief scripted remarks at the start of the kingdom's first-ever Saudi Green Initiative Forum, was timed to make a splash a little more than a week before the start of the global COP26 climate conference being held in Glasgow, Scotland.

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VOA

Apple's App Store app is seen on a smartphone in Baltimore, March 19, 2018.

Apple has updated its App Store rules to allow developers to contact users directly about payments, a concession in a legal settlement with companies challenging its tightly controlled marketplace.

According to App Store rules updated Friday, developers can now contact consumers directly about alternate payment methods, bypassing Apple's commission of 15 or 30%.

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