Tuesday October 15, 2019

Lipid, Produced in Response to Cold by Brown Adipose Tissue in Human Body, Helps Reduce Blood Sugar

The group also observed that a drug used to treat urinary dysfunction increases the amount of 12-HEPE released into the bloodstream

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Lipid, Cold, Blood Sugar
The discovery with the lipid known as 12-HEPE can pave the way for new treatments for diabetes, said the team from Brazil, the US and Germany. Pixabay

A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce blood sugar.

The discovery with the lipid known as 12-HEPE can pave the way for new treatments for diabetes, said the team from Brazil, the US and Germany.

The group also observed that a drug used to treat urinary dysfunction increases the amount of 12-HEPE released into the bloodstream in human patients.

White adipose tissue, one of the two types of adipose tissue in mammals, including humans, stores excess energy as fat.

Lipid, Cold, Blood Sugar
A team of global researchers has discovered that a lipid — produced in response to cold by brown adipose tissue in the human body — helps reduce blood sugar. Pixabay

The other kind is brown adipose tissue, which converts energy from food into heat and contributes to thermal regulation.

The function of the lipid “12-HEPE” was unknown until the group discovered that blood sugar was reduced more efficiently in obese mice treated with 12-HEPE than in untreated mice after they were injected with a concentrated glucose solution.

According to the paper published in the journal Cell Metabolism, the beneficial effect of 12-HEPE on glucose tolerance in obese mice was due to its promotion of glucose uptake into both skeletal muscle and brown adipose tissue.

The study’s first author is Luiz Osorio Leiria, a researcher at the University of Campinas’s Biology Institute (IB-UNICAMP) in Sao Paulo State, Brazil.

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The discovery lays a foundation for the development of new drugs to combat diabetes and possible new treatments with currently available drugs.

US researchers are currently conducting tests to measure the effects of relatively low doses of the drug on blood sugar levels. (IANS)

Next Story

Low-Cost Text Messaging Programme Improves Blood Sugar Control in Patients with Diabetes

Capitalising on the exponential growth in mobile phone usage over the past decade, a simple text messaging programme could increase the reach

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Diabetes, Messaging, Blood Sugar
The effect in this study was not only statistically significant but also has the potential to be clinically relevant by reducing risk of diabetic complications and death. Pixabay

Researchers have found that a low-cost text messaging programme improves blood sugar control in patients with diabetes and coronary heart disease.

“The effect in this study was not only statistically significant but also has the potential to be clinically relevant by reducing risk of diabetic complications and death,” said study researcher Xiqian Huo from Fuwai Hospital in China.

“Capitalising on the exponential growth in mobile phone usage over the past decade, a simple text messaging programme could increase the reach of diabetes self-management support,” she added.

It may provide a means to better address the burgeoning healthcare demand-capacity imbalance.

Diabetes, Messaging, Blood Sugar
Researchers have found that a low-cost text messaging programme improves blood sugar control in patients with diabetes and coronary heart disease. Pixabay

For the study presented at the ESC Congress 2019 in France, the researchers enrolled 502 patients from 34 clinics in China and the patients were randomly assigned to the text messaging intervention or a control group for six months.

The intervention group received six messages per week, at random times of the day, from an automated system set up by the researchers.

The messages were designed to provide information and motivation and help patients set goals and manage stress.

The control group received two thank you text messages per month.

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At six months, blood glycated haemoglobin (HbA1c) was significantly lower in the intervention group compared to the control group (6.7 per cent versus 7.2 per cent).

On an average, HbA1c fell by 0.2 per cent in the intervention group and rose by 0.1 per cent in the control group – a difference of 0.3 per cent between groups.

The change in fasting blood glucose was larger in the intervention, compared to control, group (-0.5 versus 0.1 mmol/L, respectively).

The intervention was acceptable to participants, 97 per cent found the text messages useful, readable and an appropriate method of contact. (IANS)