Saturday January 25, 2020

Neanderthal Genes Helped Early Human Beings to Fight Flu, Hepatitis

The team examined a list of more than 4,500 genes in modern humans that are known to interact in some way with viruses

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Neanderthal
Visitors take pictures of models representing Flores, human and Neanderthal women in the "Musee des Confluences," a new science and anthropology museum in Lyon, central France, Dec. 18, 2014. Neanderthals had a long run in Europe, but disappeared about 40,000 years ago after modern humans showed up. (VOA)

Inter-breeding with Neanderthal gave early human beings the ability to fend off dangerous diseases similar to flu and hepatitis, says a research.

The findings, led by researchers from the Universities of Arizona and Stanford, showed that while Neanderthal became extinct about 40,000 years ago, many modern Europeans and Asians today carry about 2 per cent of Neanderthal DNA in their genomes.

Early humans inherited 152 genes from Neanderthal that helped them fight off modern day HIV, influenza A and hepatitis C whenever they encountered them.

“It’s not a stretch to imagine that when modern humans met up with Neanderthals, they infected each other with pathogens that came from their respective environments,” said lead author David Enard, Assistant Professor in ecology and evolutionary biology at the University of Arizona.

Neanderthal model
Neanderthal model. Reconstruction of a Neanderthal (Homo neanderthalensis) based on the La Chapelle-aux-Saints fossils. Neanderthals inhabited Europe and western Asia between 230,000 and 29,000 years ago. They did not use complex tools but had mastery of fire and built shelters. It is thought that they had language and a complex social structure, living in small family groups and hunting for food. It is not known why Neanderthals became extinct, but one theory is that they were outcompeted by modern humans (Homo sapiens). Reconstruction by Elisabeth Daynes of the Daynes Studio, Paris, France.

“By inter-breeding with each other, they also passed along genetic adaptations to cope with some of those pathogens,” he added.

According to studies, modern humans began moving out of Africa and into Eurasia about 70,000 years ago.

When they arrived, they met up with Neanderthals who, along with their own ancestors, had been adapting to that geographic area for hundreds of thousands of years.

The Eurasian environment shaped Neanderthals’ evolution, including the development of adaptations to viruses and other pathogens that were present there but not in Africa.

In the study, published in the journal Cell, the team showed that the genetic defences that Neanderthals passed to humans were against RNA viruses, which encode their genes with RNA, a molecule that is chemically similar to DNA.

Neanderthal
Neanderthal man. Flickr

The team examined a list of more than 4,500 genes in modern humans that are known to interact in some way with viruses.

Enard then checked his list against a database of sequenced Neanderthal DNA and identified 152 fragments of those genes from modern humans that were also present in Neanderthals.

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In addition, the findings also demonstrate that it is possible to comb through a species’ genome and find evidence of ancient diseases that once afflicted it, even when the viruses responsible for those diseases are long gone.

This technique would work especially well for RNA viruses, whose RNA-based genomes are more frail than their DNA counterparts, Enard noted. (IANS)

Next Story

Full Vaccination of Children Reduces the Risk of Hospitalisation: Study

Full flu vaccination cuts child hospitalisations in half

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Hospitalisation
Researchers have found that fully vaccinated children reduced the risk of hospitalisation for complications associated with influenza by 54 per cent. Pixabay

According to a latest health news researchers have found that fully vaccinated children reduced the risk of hospitalisation for complications associated with influenza by 54 per cent.

The study, published in the journal Clinical Infectious Disease, tested the effectiveness of childhood vaccination against influenza and risk of hospitalisation due to influenza complications.

In Israel, as in the US, government guidelines recommend that children aged 8 or younger who have never been vaccinated, or who have only had one dose of flu vaccine previously, should receive two doses of vaccine.

“Children vaccinated according to government guidelines are much better protected from influenza than those who only receive one vaccine, said study lead author Hannah Segaloff from University of Michigan in the US.

According to the researchers, over half of our study population had underlying conditions that may put them at high risk for severe influenza-related complications, so preventing influenza in this group is critically important.

Hospitalisation
Young children who aren’t vaccinated are at high risk of hospitalisation due to influenza complications. Pixabay

“Our results also showed that the vaccine was effective in three different seasons with different circulating viruses, reinforcing the importance of getting an influenza vaccine every year no matter what virus is circulating,” Hannah said.

The retrospective study used data from Clalit Health Services, the largest health fund in Israel, to review the vaccination data of 3,746 hospitalisations of children 6 months to 8 years old at six hospitals in Israel. They were tested for influenza over three winter seasons 2015-16, 2016-17 and 2017-18.

Not only do the findings reveal that the flu vaccine reduced hospitalizations associated with the flu by 54 per cent, but they show that giving two vaccine doses to children up to age 8 who have never been vaccinated or only received one dose previously is more effective than administering one dose, in accordance with the Israel Ministry of Health recommendations.

“Young children are at high risk of hospitalisation due to influenza complications. Children with underlying illnesses such as asthma and heart disease have an even greater risk of getting the complications. It is important to prevent influenza infections in these populations,” said study co-author Mark Katz, from The Clalit Research Institute in Israel.

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The findings support health organisations’ recommendations to vaccinate children against influenza every year, preferably before the onset of winter or early childhood. Children under 5 are defined as having a high risk of influenza complications, the researchers said. (IANS)