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New York: Researchers have identified promising drug compounds that could successfully treat depression in less than 24 hours while minimizing side effects.

Although they have not yet been tested on people, the compounds could offer significant advantages over current antidepressant medications, the study said.


“Our results open up a whole new class of potential antidepressant medications,” said lead researcher Scott Thompson, professor at the University of Maryland School of Medicine in the US.


“These compounds can relieve the devastating symptoms of depression in less than one day and can do so in a way that limits some of the key disadvantages of current approaches,” Thompson said in the study published in the journal Neuropsychopharmacology.

These compounds, called GABA-NAMs, minimise unwanted side effects because they are precise: they work only in the parts of the brain that are essential for mood, the study said.

The compounds were tested in rats that were subjected to chronic mild stress and caused the animals to act in ways that resemble human depression.

Giving stressed rats GABA-NAMs successfully reversed experimental signs of a key symptom of depression, anhedonia, or the inability to feel pleasure.

Remarkably, the beneficial effects of the compounds appeared within 24 hours – much faster than the multiple weeks needed for most of the currently available antidepressants called selective serotonin re-uptake inhibitors, or SSRIs to produce the same effects.

“These compounds produced the most dramatic effects in animal studies that we could have hoped for.”

“It will be exciting to find out whether they produce similar effects in depressed patients. If these compounds can quickly provide relief of the symptoms of human depression, such as suicidal thinking, it could revolutionise the way patients are treated,” Thompson said.

No effects of the compound were detected in unstressed animals, raising hopes that they will not produce side effects in human patients.


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Photo by Priscilla Du Preez on Unsplash

Your monthly round up of the latest lifestyle launches, from luxury indulgences to artisanal creations.

By Nimerta C Sharan

Your monthly round up of the latest lifestyle launches, from luxury indulgences to artisanal creations, here's what you can look forward to :

Bag This
Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags 'Artycapucines - Chapter 3'. Six internationally -- acclaimed artists have transformed the black canvas of the timeless Capucines bag into beautiful art pieces. Each bag will be available in a limited edition of 200 and will be released worldwide at the end of October 2021.

white leather shoulder bag on shopping cart Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags. | Photo by Erik Mclean on Unsplash

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IANS

Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body

Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body and left her with "permanent stretch marks". For her role in the film, based on the life of late Tamil Nadu Chief Minister and former actress J. Jayalalithaa, Kangana had to gain 20kg and undergo major physical transformation several times.

She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.

"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.

She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)


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Wikimedia Commons

Signal's encrypted messaging app continues to be down on Monday after facing global outage on Sunday.

Signal's encrypted messaging app continues to be down on Monday after facing global outage on Sunday. The firm said it is working to fix it. "Hold tight, folks! Signal is currently down, due to a hosting outage affecting parts of our service. We're working on bringing it back up," the firm said in a tweet on Sunday.

The status website says the encrypted messaging app is "experiencing technical difficulties" and many people are also getting an in-app error message that says the same thing. Signal allows for secure and encrypted video, voice and text communication, but users are unable to send any messages.

According to Downdetector.com, users started reporting outages around 11:05 PM Eastern Standard Time and it appears to be affecting people around the world. Comments shared on Downdetector.com indicates that Signal was down for users from India, US, Germany, New Zealand, Netherlands, Australia, Brazil and many other countries.

"Down in Midwest USA. Signal was started by people connected to which secret 3-letter organization? (Look it up) Yep, that's right! An app disguised a privacy app to trick you into sharing more private information than you would with another messaging app," a user said. "I think Signal is having a rough day. Good luck, Team Signal. I'm sure you'll have it sorted out in a snap," said another. The encrypted messaging service has climbed to the top spot in the free apps category of the App Store in multiple countries, including India. (IANS/ MBI)


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