Never miss a story

Get subscribed to our newsletter


×



New York: A vaccine regimen that first primes the immune system and then boosts it to increase the response could ultimately prove to be the strategy for protecting against the global human immunodeficiency virus (HIV-1) infection, a new research suggests.

The study showed that the experimental “prime-boost” vaccine regimen provided complete protection to non-human primates from becoming infected with simian immunodeficiency virus (SIV), a virus similar to HIV that infects the primates.

These results have now encouraged scientists to study the efficacy of the vaccine on a human study that is currently enrolling 400 volunteers in the US and Rwanda, with sites in South Africa, Uganda and Thailand opening soon.

“We are very encouraged by the results of this preclinical HIV vaccine study, and the findings lead to a clear path forward for evaluating this HIV vaccine candidate in humans,” said lead author Dan Barouch, professor of medicine at the Harvard Medical School.

For the study, non-human primates (NHP) were first given an adenovirus serotype 26 (Ad26) vectored vaccine to prime the immune system, and then a boost of a purified HIV envelope protein intended to enhance the immune system over time.

This approach is intended to increase both the magnitude of the immune response and the overall protection against subsequent viral challenge.

“Despite great progress in HIV treatments, HIV remains one of the greatest global health threats of our time with millions continuing to be infected each year. Our ultimate goal is to develop a vaccine that prevents HIV in the first place,” said Paul Stoffels from the Johnson & Johnson, which collaborated on the research.

The study was published in the online edition of the journal ‘Science’. (IANS)


Popular

Photo by Hassan Vakil on Unsplash

When we are experiencing loneliness, it can be easy to slip into the habit of saying no to social activities.

By N. Lothungbeni Humtsoe

The festive season is a time of joy. Some people truly love it, but for many, it can trigger feelings of loneliness and anxiety. Feeling lonely is common and completely normal -- whether or not we're living through this pandemic. The social pressure to "be happy" can be relentless, but it is important to take a proactive approach to meet not only our emotional needs but also to maintain our mental stability and well-being. With the pandemic, holidays are likely to be challenging, instead, meet them head-on with a renewed dedication and a proactive mindset to avoid 'holiday blues'.

Kanchan Rai, Mental and Emotional Well-being Coach, Founder, Let Us Talk, mentions ways to turn your loneliness into action this season:

Say yes to socializing: When we are experiencing loneliness, it can be easy to slip into the habit of saying no to social activities. Seclusion can make it challenging to feel driven and the mere thought of physically seeing people can lead to stress. Hence it is recommended to saying yes to mingling to help build your confidence. Something as simple as going for a walk with a friend or chatting with your loved ones over the phone can make a huge difference.

three women walking on brown wooden dock near high rise building during daytime It is recommended to saying yes to mingling to help build your confidence | Photo by Priscilla Du Preez on Unsplash

Keep Reading Show less
Ctrl.blog

Ahead of the Windows 11 launch, Microsoft is rolling out some updates to Edge

Ahead of the Windows 11 launch, Microsoft is rolling out some updates to Edge that include the addition of tab groups. Users will be able to assemble collections of tabs to make their browser a little less chaotic.

To create a group, hold the control button and choose the tabs you want to include, then select "Add tabs to new group" from the right-click menu, Engadget reported on Friday. Users can customise the label with a different colour for each group. When users hover over a tab, they will be able to see a preview of the web page as well.

Microsoft Edge is also getting some handy shopping features, the report said. The browser can give swift access to reviews and ratings for more than 5 million products. When users are on a product page, they can click the blue tag on the address bar and see expert reviews from reliable sources, as well as the average consumer star rating from various retailers.

When they do figure out what to buy, Microsoft aims to help them complete the transaction a bit faster. The new personalised news feed called Microsoft Start is integrated into the browser. Users will see headlines and articles relevant to their interests from a range of publishers when they open a new tab. (IANS/ MBI)


Keep Reading Show less
Photo by Alex Padurariu on Unsplash

What are black foods? Foods with the pigments called anthocyanins are known as black foods.

When you think of the colours on your plate, do you ever think of black? Well, its time you do! As they are the new power food. We all know greens, yellows and reds are loaded with nutrients -- so are the lesser spoken about black ones too!

What are black foods? Foods with the pigments called anthocyanins are known as black foods. Anthocyanins are found in black, blue and purple coloured foods and have hidden nutrients and benefits galore. These pigments have rich anti-oxidant properties which promote health and have the potential to reduce the risk of cancer, heart disease and stroke. They play a huge role in immunity. They are fun, healthy, offbeat and make for a nice visual treat too.

Abhilasha V, HOD and Chief Clinical Nutritionist -- Cloudnine group of hospitals, Bengaluru, few interesting ones and their benefits:

Black Rice
Cultivated in South East Asian belt, this rice has a nutty flavour and can be used in many recipes. In China this was known as the Forbidden rice in ancient times as it was reserved for only royalty. Now, some parts of north East India grow black rice too. They are loaded with lutien and zeaxanthin and promote good eye health. They have cancer fighting properties due to their high anti-oxidant and fiber content. They can be used in puddings, stir fries, risotto, porridge, noodles, bread and even makes a great idea for a good kheer!

black and brown bean lot Cultivated in South East Asian belt, this rice has a nutty flavour and can be used in many recipes. | Photo by Joanna Kosinska on Unsplash

Keep reading... Show less