Monday April 22, 2019

Researchers Develop Novel Device to Identify Early Symptoms of Sepsis

cNEWS will now be introduced carefully into hospitals with appropriate information technology infrastructure

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Vaccine
Influenza leads to serious and potentially life-threatening complications such as pneumonia, sepsis and heart disease, the study noted. VOA

Researchers have developed a new computer-aided model to identify early symptoms of sepsis — a potentially life-threatening condition caused by the body’s response to an infection.

Sepsis is a major cause of death in hospitals, and early detection is key to preventing deaths. Every hour of delay is linked to a 7 per cent reduction of survival.

The study showed that the computer-aided National Early Warning Score (cNEWS) determined if it could enhance the accuracy of predicting sepsis. The score can trigger screening for sepsis within 30 minutes.

scientists, genome
FILE – Researcher Ben Matthews speaks in a room housing mosquitoes in the Vosshall Laboratory at Rockefeller University in New York, Feb. 12, 2019. VOA

“The main advantage of these computer models is that they are designed to incorporate data that exist in the patient record, can be easily automated and place no extra burden on the hospital staff to collect additional information,” said Mohammed A. Mohammed, Professor at the University of Bradford in Britain.

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“These risk scores should support, rather than replace, clinical judgment. We hope they will heighten awareness of sepsis with additional information on this serious condition,” he added, in the paper published in Canadian Medical Association Journal.

cNEWS will now be introduced carefully into hospitals with appropriate information technology infrastructure, the study noted. (IANS)

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Consuming Low-fibre, High-fat Diet Can Spike up Risk of Sepsis

The team also identified molecular markers in Western diet-fed mice that could be used as predictors or biomarkers for patients that are at high risk for severe sepsis or patients that may need more aggressive treatment

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Diet
A dish of steak and cheese pasta is ready to eat in Concord, N.H., June 9, 2014. Two major studies in 2018 provided more fuel for the debate around carbs and fats, yet failed to offer a resolution to the polarizing matter of the best way to lose weight. VOA

Consuming a Western diet, low in fibre and high in fat and sugar, can put you at increased risk of developing severe sepsis, researchers say.

The study, published in the journal Proceedings of the National Academy of Sciences, found mice that were fed the Western diet showed an increase in chronic inflammation, sepsis severity and higher mortality rates than mice that were fed a normal diet.

Sepsis is a potentially life-threatening condition caused by the body’s response to an infection. It can lead to shock and organ failure. It is one of the most common cause of death worldwide.

According to the researchers, including Brooke Napier from the Portland State University, the mice had more severe sepsis and were dying faster because of something in their diet, not because of the weight gain or microbiome, the body’s community of bacteria.

“The mice’s immune system on the Western diet looked and functioned differently. It looks like the diet is manipulating immune cell function so that you are more susceptible to sepsis, and then when you get sepsis, you die quicker,” Napier said.

Food , delivery, diet
Low-fibre, high-fat diet may up severe sepsis risk. Flickr

The researcher said the findings can help hospitals better monitor the diets of patients in the intensive care unit (ICU) since they are already the ones most likely to develop sepsis.

“If you know that a diet high in fat and sugar correlates with increased susceptibility to sepsis and increased mortality when those patients are in the ICU, you can make sure they’re eating the right fats and the right ratio of fats,” she said.

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“If you could introduce a dietary intervention while they are in the ICU to decrease their chances of manipulating their immune system in that way, you can somehow influence the outcome,” she added.

The team also identified molecular markers in Western diet-fed mice that could be used as predictors or biomarkers for patients that are at high risk for severe sepsis or patients that may need more aggressive treatment. (IANS)