Friday November 16, 2018

A Protein That Can Stop Cancer?

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The research showed that LHPP emerged as the top favourite. Pixabay
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Researchers have discovered a protein that prevents the uncontrolled proliferation of cancer cells in the liver.

The anti-cancer protein, called LHPP, can also serve as a biomarker for the diagnosis and prognosis of liver cancer, said the study published in the journal Nature.

The incidence of liver cancer, also known as hepatocellular carcinoma, is usually diagnosed at a very late stage when the liver is already severely damaged and hence overall prognosis is poor.

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The researchers believe that detection of the anti-cancer protein LHPP as a biomarker may allow clinicians to provide better treatment options.

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“It is striking that LHPP is present in healthy tissue and completely absent in tumour tissue,” said first author Sravanth Hindupur from University of Basel in Switzerland. Pixabay

 

In the study conducted in a mouse model for hepatocellular carcinoma, the researchers analyzed a total of more than 4,000 proteins, comparing them in healthy and tumour tissue.

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Re-introduction of the genetic information for LHPP by the researchers was found to prevent the formation of tumours and maintain liver function.

“Similar to the mouse model, we also saw a striking decrease in LHPP levels in tumours of patients with liver cancer,” Hindupur said. (IANS)

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High Exposure to Radio Frequency Radiation Increase Risk of Cancer

Interestingly, the team found that rats exposed to whole body RFR lived longer than rats unexposed to any radiation

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High exposure to radio frequency radiation linked to cancer. Pixabay

Exposure to high levels of radio frequency radiation (RFR) — used in 2G and 3G cell phones — can increase the risk of cancer tumours in the heart, brain and adrenal gland, researchers have warned.

The study, led by the US National Institutes of Health’s National Toxicology Programme (NTP), looked at the effects of exposing rodents to extremely high levels of radiofrequency throughout the entire body.

While high levels of RFR caused cancerous tumours in the heart (found very rarely in humans), brain and adrenal gland, of male rats, the findings on female rats were ambiguous.

“The exposures used in the studies cannot be compared directly to the exposure that humans experience when using a cell phone. In our studies, rats and mice received radio frequency radiation across their whole bodies,” John Bucher, researcher from the NTP, said in a statement.

“By contrast, people are mostly exposed in specific local tissues close to where they hold the phone,” Bucher added.

For the study, the team housed the animals in chambers specifically designed for the study.

Exposure to RFR began in the womb for rats and at 5 to 6 weeks old for mice, and continued for up to two years, or most of their natural lifetime.

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Cancer ribbon. Pixabay

However, the RFR exposure was intermittent — 10 minutes on and 10 minutes off — totalling about nine hours each day.

In addition, the RFR levels ranged from 1.5-6 watts per kilogram in rats, and 2.5-10 watts per kilogram in mice.

“We believe that the link between radio frequency radiation and tumours in male rats is real,” Bucher noted.

Interestingly, the team found that rats exposed to whole body RFR lived longer than rats unexposed to any radiation.

“This may be explained by an observed decrease in chronic kidney problems that are often the cause of death in older rats,” the researchers noted.

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According to the US Food and Drug Administration (FDA), while animal studies contribute to discussions on the topic, “this study was not designed to test the safety of cell phone use in humans, so we cannot draw conclusions about the risks of cell phone use from it.”

Since the exposure levels and durations in the studies were greater than what people experience, “we agree that these findings should not be applied to human cell phone usage”, the FDA said on Thursday. (IANS)