Tuesday December 10, 2019

A Protein That Can Stop Cancer?

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protein
The research showed that LHPP emerged as the top favourite. Pixabay

Researchers have discovered a protein that prevents the uncontrolled proliferation of cancer cells in the liver.

The anti-cancer protein, called LHPP, can also serve as a biomarker for the diagnosis and prognosis of liver cancer, said the study published in the journal Nature.

The incidence of liver cancer, also known as hepatocellular carcinoma, is usually diagnosed at a very late stage when the liver is already severely damaged and hence overall prognosis is poor.

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The researchers believe that detection of the anti-cancer protein LHPP as a biomarker may allow clinicians to provide better treatment options.

protein
“It is striking that LHPP is present in healthy tissue and completely absent in tumour tissue,” said first author Sravanth Hindupur from University of Basel in Switzerland. Pixabay

 

In the study conducted in a mouse model for hepatocellular carcinoma, the researchers analyzed a total of more than 4,000 proteins, comparing them in healthy and tumour tissue.

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Re-introduction of the genetic information for LHPP by the researchers was found to prevent the formation of tumours and maintain liver function.

“Similar to the mouse model, we also saw a striking decrease in LHPP levels in tumours of patients with liver cancer,” Hindupur said. (IANS)

Next Story

Light Alcohol Consumption Might Also Increase Cancer Risk: Study

The researchers found an almost linear association between cancer risk and alcohol consumption

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Alcohol
A light level of Alcohol Consumption at 10-drink-year point, for example, one drink per day for 10 years or two drinks per day for five years would increase cancer risk by five per cent, the findings showed. Pixabay

If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light Alcohol consumption might increase the cancer risk.

In the study published in the journal Cancer, the overall cancer risk appeared to be the lowest at zero alcohol consumption. The elevated risk appeared to be explained by alcohol-related cancer risk across relatively common sites, including the colorectum, stomach, breast, prostate and esophagus.

“In Japan, the primary cause of death is cancer,” said one of the researchers Masayoshi Zaitsu from The University of Tokyo. “Given the current burden of overall cancer incidence, we should further encourage promoting public education about alcohol-related cancer risk,” Zaitsu said.

The team examined clinical data on 63,232 patients with cancer and 63,232 controls matched for sex, age, hospital admission date, and admitting hospital. The data was gathered from 33 general hospitals in Japan.

All participants reported their average daily amount of standardised alcohol units and the duration of drinking.

One standardised drink containing 23 grams of ethanol was equivalent to one 180-ml cup of Japanese sake, one 500-ml bottle of beer, one 180-ml glass of wine, or one 60-ml cup of whiskey.

Alcohol
If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light Alcohol consumption might increase the cancer risk. Pixabay

The researchers found an almost linear association between cancer risk and alcohol consumption.

A light level of drinking at 10-drink-year point, for example, one drink per day for 10 years or two drinks per day for five years would increase cancer risk by five per cent, the findings showed.

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Those who drank two or fewer drinks a day had an elevated cancer risk regardless of how long they had consumed alcohol. Also, analyses classified by sex, drinking/smoking behaviours and occupational class mostly showed the same patterns. (IANS)