Monday April 22, 2019

A Protein That Can Stop Cancer?

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The research showed that LHPP emerged as the top favourite. Pixabay

Researchers have discovered a protein that prevents the uncontrolled proliferation of cancer cells in the liver.

The anti-cancer protein, called LHPP, can also serve as a biomarker for the diagnosis and prognosis of liver cancer, said the study published in the journal Nature.

The incidence of liver cancer, also known as hepatocellular carcinoma, is usually diagnosed at a very late stage when the liver is already severely damaged and hence overall prognosis is poor.

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The researchers believe that detection of the anti-cancer protein LHPP as a biomarker may allow clinicians to provide better treatment options.

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“It is striking that LHPP is present in healthy tissue and completely absent in tumour tissue,” said first author Sravanth Hindupur from University of Basel in Switzerland. Pixabay

 

In the study conducted in a mouse model for hepatocellular carcinoma, the researchers analyzed a total of more than 4,000 proteins, comparing them in healthy and tumour tissue.

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Re-introduction of the genetic information for LHPP by the researchers was found to prevent the formation of tumours and maintain liver function.

“Similar to the mouse model, we also saw a striking decrease in LHPP levels in tumours of patients with liver cancer,” Hindupur said. (IANS)

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Research Reveals, Cancer Patients Are More Likely To Use Marijuana

"Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,"

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The researchers found significantly increased use of marijuana over time -- likely reflecting increased availability due to legislative changes -- but they found stable rates of opioid use. Pixabay

Many cancer patients use marijuana and its usage has increased, a new study suggests. The findings, published in the journal CANCER, indicate 40.3 per cent cancer patients used marijuana within the past year, compared with 38 per cent of respondents without cancer.

“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego.

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They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent. Pixabay

For the study, 826 people with cancer were matched to 1,652 controls.

The researchers found significantly increased use of marijuana over time — likely reflecting increased availability due to legislative changes — but they found stable rates of opioid use.

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“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego. VOA

They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent.

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“Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,” said lead author Jona Hattangadi-Gluth from the varsity. (IANS)