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The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder. Pixabay

Researchers have identified a gene that could provide a new target for developing medication to prevent and treat alcoholism, according to a new study on mice.

Researchers at Oregon National Primate Research Center (ONPRC) in the US discovered a gene that had lower expression in the brains of non-human primates which voluntarily consumed heavy amounts of alcohol compared to those that drank less.


Furthermore, the team unraveled a link between alcohol and how it modulates the levels of activity of this particular gene.


The study modified the levels of the protein encoded by a single gene known as GPR39. Pixabay

Researchers discovered that when they increased the levels of the gene encoded protein in mice, they reduced alcohol consumption by almost 50 per cent without affecting the total amount of fluid consumed or their overall well-being.

The study modified the levels of the protein encoded by a single gene known as GPR39.

The prevalence rates of co-occurring mood and alcohol use disorders are high, with individuals with alcohol use disorder being 3.7 times more likely to have major depression than those who do not abuse alcohol.

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Using a commercially available substance that mimics the activity of the GPR39 protein, the researchers found that targeting this gene dramatically reduced alcohol consumption in mice, showed the findings of the study published in the journal, Neuropsychopharmacology.

“The study highlights the importance of using cross-species approaches to identify and test relevant drugs for the treatment of alcohol use disorder,” noted senior author Rita Cervera-Juanes, Research Assistant Professor at ONPRC. (IANS)


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When you're pregnant, the immune system is seeing the placenta for the first time in decades.

The US researchers have discovered a class of immune cells that plays a role in miscarriage, which affects about a quarter of pregnancies.

Researchers at the University of California-San Francisco found that the recently discovered subset of cells known as extrathymic Aire-expressing cells in the immune system may prevent the mother's immune system from attacking the placenta and fetus.

The researchers showed that pregnant mice who did not have this subset of cells were twice as likely to miscarry, and in many of these pregnancies fetal growth was severely restricted.

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"When you're pregnant, the immune system is seeing the placenta for the first time in decades -- not since the mother made a placenta when she herself was a fetus," said Eva Gillis-Buck, from UCSF.

"Our research suggests that this subset of immune cells is carrying out a sort of 'secondary education' -- sometimes many years after the better-known population of the educator cells have carried out the primary education in the thymus -- teaching T cells not to attack the fetus, the placenta and other tissues involved in pregnancy," she added. The findings are published in the journal Science Immunology.

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It's not surprising that over half of those surveyed feel more comfortable using emojis than talking on the phone or in person.

The tiny emojis being shared on billions of devices worldwide can play a major role in digital communication, with most people saying that emoji compels them to feel more empathy towards others, according to an Adobe report.

Adobe's global emoji study found that emoji even helps people overcome language barriers and form connections that would otherwise be difficult to do.

"We were surprised and delighted by the discoveries made in the survey, most notably how enthusiastic respondents were for emoji as a means to express themselves," the company said in a statement.

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Emojis sometimes get criticized for being overly saccharine, but this sweetness is key when it comes to diffusing some of the heaviness of online communication.

"Many of the emoji are focused on positive emotions, so it's easy to insert them into our conversations and lighten the mood," the Adobe study said.

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Jeff Bezos at the ENCORE awards.

Following the grand Richard Branson show where he carried Andhra Pradesh-born Sirisha Bandla and fellow space travelers on his shoulders after successfully flying to the edge of space, it is time for Amazon Founder Jeff Bezos to applaud Sanjal Gavande, one of the key engineers who designed the New Shephard rocket set to take Bezos and the crew to space on July 20.

Billionaire Bezos is set to fly to the edge of space aboard what is touted as the world's first unpiloted suborbital flight. Born in Kalyan, Maharashtra, Gavande is a systems engineer at Blue Origin who always dreamt of designing aerospace rockets.

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After completing Bachelor's in mechanical engineering from the University of Mumbai, she flew to the US in 2011 to pursue a Master's in mechanical engineering from the Michigan Technological University. She also applied for an engineering job at the US space agency NASA but finally landed her dream job at Blue Origin

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