Never miss a story

Get subscribed to our newsletter


×
Using a data-driven approach, the researchers analyzed 184 data sets generated from sequencing PDX samples. Pixabay

Researchers have found a possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials. In the study, published in the journal Nature Communications, researchers reported the extensive presence of mouse viruses in patient-derived xenografts (PDX).

PDX models are developed by implanting human tumor tissues in immune-deficient mice and are commonly used to help test and develop cancer drugs.


Follow NewsGram on Twitter to stay updated about the World news.

“What we found is that when you put a human tumor in a mouse, that tumor is not the same as the tumor that was in the cancer patient,” said researcher W. Jim Zheng from the University of Texas.”The majority of tumors we tested were compromised by mouse viruses,” Zheng added.


Cancer drugs that kill tumor cells in mouse models won’t work in human trials. Pixabay

Using a data-driven approach, the researchers analyzed 184 data sets generated from sequencing PDX samples. Of the 184 samples, 170 showed the presence of mouse viruses. The infection is associated with significant changes in tumors, and the researcher said that could affect PDX as a drug testing model for humans.

ALSO READ: Everything on Cancer Care Amid COVID-19 With Cancer Expert Dr. Abhishek Shankar

“When scientists are looking for a way to kill a tumor using the PDX model, they assume the tumor in the mouse is the same as cancer patients, but they are not,” Zheng said.

“It makes the results of a cancer drug look promising when you think the medication kills the tumor — but in reality, it will not work in human trials, as the medication kills the virus-compromised tumor in mice,” Zheng added. (IANS/JC)


Popular

Wikimedia Commons

Amitabh Bachchan, during his speech to the crowd of over 80,000 people at the Reliance Industries' annual event, said that the legacy left by Dhirubhai has had a positive impact on millions of people's lives worldwide.

Amitabh Bachchan is adored by the public for his unforgettable on-screen performances as well as his magnetic demeanour. Not only do fans love Amitabh Bachchan's outstanding performance, but the actor's heartwarming words are also highly regarded. A much moved Amitabh Bachchan, during his speech to the crowd of over 80,000 people at the Reliance Industries' annual event, said that the legacy left by Dhirubhai has had a positive impact on millions of people's lives worldwide.

When Bollywood superstar Amitabh Bachchan became bankrupt in the late 1990s, Dhirubhai Ambani stepped forward to give him financial assistance. In his speech, Bachchan remembered that Dhirubhai had sent Anil Ambani to offer him financial assistance during the crisis, which he had respectfully declined. Lenders began knocking on his door, losses mounted, and his bank account dwindled to nothing. He said, "Dhirubhai's money might have gotten me out of the problem quickly. However, I respectfully declined his offer and gradually began to find work again, which let me pay off my debt."

Keep Reading Show less
Photo by Xavier Mouton Photographie on Unsplash

Irrespective of the age of your child, it is vital for parents to offer that extra support and assistance following an unsettling event.

In comparison to adults, children are prone to getting traumatized by troubling events easily, and this makes it important for parents to help their children when the times are tough. It could be a brutal accident, an unprecedented pandemic, a violent crime, or other disasters but with the right parental support, children have a higher chance of coming out stronger from an awful situation.

Anuja Kapur, Psychologist shares few tips wherein you can assist your child when tough times comes calling:

Every child responds differently to disturbing events:
What children feel about a current disaster in their life and how they react to it can come and go in waves. Children can act moody and withdrawn at times, struck with sorrow and fear at other times. There's no absolute "right" or "wrong" way to feel after a traumatic event so make sure not to dictate what your child or how your child should feel and react to the event.

a boy crying tears for his loss Children can act moody and withdrawn at times, struck with sorrow and fear at other times. | Photo by Kat J on Unsplash

Keep Reading Show less
Photo by Andreas Haslinger on Unsplash

European consumers will be able to use a single charger for all their portable electronics - an important step to increase convenience and reduce waste.

The European Commission, the executive arm of the European Union (EU), has announced plans for smartphone and other electronics manufacturers to fit a common USB-C charging port on their devices in an effort to reduce waste. In addition to phones, the rules will apply to other devices like tablets, headphones, portable speakers, videogame consoles, and cameras, reports The Verge. The decision will have a huge impact on Apple, as the company still uses its own Lightning connector to charge iPhones. The proposals only cover devices using wired, not wireless and a USB-C port is only mandatory for devices that charge using a cable.

Different charging cables "Chargers power all our most essential electronic devices | Photo by Solen Feyissa on Unsplash

Keep reading... Show less