Thursday, May 13, 2021
Home Life Style Health & Fitness This Molecule Helps Covid-19 Escape Antibodies

This Molecule Helps Covid-19 Escape Antibodies

In the first months of the pandemic, scientists were extremely busy churning out viral antigens for SARS-CoV-2 tests

A natural molecule called biliverdin present in the human body is helping SARS-CoV-2, the virus that causes Covid-19, escape antibodies – a discovery that can help explain why some Covid patients become severely ill despite having high levels of antibodies against the virus, report researchers. When SARS-CoV-2 infects a patient’s lungs, it damages blood vessels and causes a rise in the number of immune cells.

“Both of these effects may contribute to increasing the levels of biliverdin and bilirubin in the surrounding tissues. And with more of these molecules available, the virus has more opportunity to hide from certain antibodies,” said Annachiara Rosa, first study author at the Francis Crick Institute in the UK.”This is a really striking process, as the virus may be benefiting from a side-effect of the damage it has already caused,” Rosa said in the paper published in the journal Science Advances.

Follow NewsGram on Instagram to keep yourself updated.

In their research, teams from the Francis Crick Institute, in collaboration with researchers at Imperial College London, Kings College London, and UCL (University College London), found that biliverdin and bilirubin, natural molecules present in the body, can suppress the binding of antibodies to the coronavirus spike. As vaccines are rolled out globally, understanding immunity to SARS-CoV-2 and also how the virus evades antibodies is critically important.

molecule
The researchers are now exploring if it is possible to hijack the binding site used by biliverdin to potentially find new ways to target the virus. Pixabay

The ability of the immune system to control the infection and the quality of the antibody response is highly variable, and not well correlated, between individuals. The scientists discovered that the SARS-CoV-2 spike protein strongly binds to biliverdin, a molecule that was giving these proteins an unusual green coloration.

ALSO READ: Radiant Cooling Likely To Replace ACs, Cut Covid Risk

They found that biliverdin attaches to the spike N-terminal domain and stabilizes it so that the spike is not able to open up and expose parts of its structure. This means that some antibodies are not able to access their target sites and so cannot bind to and neutralize the virus. In the first months of the pandemic, scientists were extremely busy churning out viral antigens for SARS-CoV-2 tests.

“It was a race, as these tests were urgently needed. When we finally found the time to study our green proteins, we expected a mundane answer. Instead, we were astonished to discover a new trick the virus uses to avoid antibody recognition,” explained Peter Cherepanov, author and a group leader of the Chromatin structure and mobile DNA Laboratory at the Crick. The researchers are now exploring if it is possible to hijack the binding site used by biliverdin to potentially find new ways to target the virus. (IANS/JC)

STAY CONNECTED

19,511FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

France, UK Concerned About Resurgence In Jihadist Threat

By Jamie Dettmer Nearly 200 jihadists imprisoned in France are due to be released over the next two years and French security officials are pressing French...

What You Need To Know About The Bombings In Gaza By Israeli

BY- JAYA CHOUDHARY Israeli bombings on the Gaza Strip have killed at least 21 people including 16 Palestinians. Among the diseased was a 32-year-old Indian...

Instagram Lets Users Add Pronouns To Their Profiles

Facebook-owned Instagram has announced to let users add up to four pronouns to their profiles, which they can then display publicly or only to...

Queen Elizabeth II Of The UK Presents The Government Agenda

Britain's Queen Elizabeth delivered the official Opening of Parliament speech Tuesday, her first ceremonial appearance since the death of her husband, Prince Philip. The speech,...

How To Recover Nikon Camera Photos

By Hasan Raza Introduction DSLR cameras have long been utilized in the white-collared photography business sector. DSLR’s notoriety in the global marketplace has also increased significantly...

Working On A Cremation Ground During The COVID Period

The shades of dusk are falling -- it is time to exit this space. But people continue to come in with their dead. The...

Healthy India: Encouraging Nursing Education In Schools

The Covid-19 pandemic has not just rattled the lives of millions but has put Indian healthcare machinery under tremendous pressure. From doctors to nurses to...

International Nurses Day: History And Significance

By- Khushi Bisht The International Nurses Day is observed on May 12th every year worldwide to honor the contributions of nurses. The International Council of...

Recent Comments