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Immunologists have discovered a previously unknown mechanism of a type of white blood cell that acts like a spider web, trapping and killing pathogens such as influenza or SARS-CoV-2, the virus responsible for Covid-19.
The researchers, from McMaster University in Canada, have found that neutrophils -- the most abundant white blood cells in the human body -- explode when they bind to such pathogens coated in antibodies and release DNA outside of the cell, creating a sticky tangle that acts as a trap.
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The findings, published online in the Proceedings of the National Academy of Science, are significant because little is understood about how antibodies neutralise viruses in the respiratory tract.
The discovery also has implications for vaccine design and delivery, including aerosol and nasal spray technologies that could help the body head off infections before they have a chance to take hold, the researchers said.
"Vaccines can produce these antibodies that are present in our lungs, which are the first type of antibody to see viruses like flu or Covid-19, which infect our lungs and respiratory tracts," says the study's lead author Matthew Miller, Associate Professor at McMaster's Michael G DeGroote Institute for Infectious Disease Research.
"Mechanisms that can stop the infection at the site where it enters our body can prevent the spread and serious complications," he added.
By comparison, injectable vaccines are designed to bolster antibodies in the blood, but those antibodies are not as prevalent at the sites where the infection begins.
"We should be thinking carefully about next-generation Covid-19 vaccines that could be administered in the respiratory tract to stimulate antibodies," said lead author Hannah Stacey, a graduate student in the Miller's Lab.
"If you want a lot of these antibodies that are abundant in blood, then injections make the most sense, but if you want antibodies that are abundant in the respiratory tract, then a spray or an aerosol makes sense," she noted.
Researchers caution that while the body's spider-web mechanism has the potential to be hugely beneficial, it can cause harm too, including inflammation and further illness when the web formation is uncontrollable.
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They point to the early waves of the pandemic, before vaccinations, when these NETs, or neutrophil extracellular traps, were found in some patients' lungs and had made their breathing more difficult. (IANS/AD)
By Nimerta C Sharan
Your monthly round up of the latest lifestyle launches, from luxury indulgences to artisanal creations, here's what you can look forward to :
Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags 'Artycapucines - Chapter 3'. Six internationally -- acclaimed artists have transformed the black canvas of the timeless Capucines bag into beautiful art pieces. Each bag will be available in a limited edition of 200 and will be released worldwide at the end of October 2021.
Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags. | Photo by Erik Mclean on Unsplash
Add To Cart
Looking for a quick festive fashion fix for you and your loved ones? E-commerce giant AJIO has announced it's hottest fashion sale starting September 30, 2021. The shopping platform has roped in stylista Sonam Kapoor as the face of the sale that will offer more than 2500 brands at discounted prices.
E-commerce giant AJIO has announced it's hottest fashion sale starting September 30, 2021. | Photo by Mitchell Luo on Unsplash
The country's leading design house, Good Earth, in collaboration with textile designer Madeline Weinrib will present its collection of 'butah' motif dinnerware and home textiles at the Metropolitan Museum of Arts, New York. The 'Heirloom Project' that honours diverse Islamic design techniques will display curated products from across the globe.
The 'Heirloom Project' that honours diverse Islamic design techniques will display curated products from across the globe. | Photo by Jean Vella on Unsplash
Sweet dreams are made of this! Iconic French patisserie Laduree has opened its first Indian outpost at Delhi's upscale Khan Market. Spread over three floors, the bakery currently has twelve macaron flavours, their signature pastries and tea cakes and other brunch and high-tea items on the menu. Bon appetit.
Iconic French patisserie Laduree has opened its first Indian outpost at Delhi's upscale Khan Market. | Pixabay
Bright And Beautiful
Raw Mango's latest festive edit 'Moomal' goes live on their website on September 26, 2021. Inspired by the richness and diversity of Rajasthan, the collection consists of organza and silk saris and shararas, gota lehengas and kurtas and embroidered odhnis. The colours and silhouettes are just right for the upcoming festive season. (IANS/ MBI)
Raw Mango's latest festive edit 'Moomal' goes live on their website on September 26, 2021. | Photo by Souravi Sinha on Unsplash
Keywords: Lifestle, AJIO, sale, Deepika PAdukone, saris, Motifs, artisan, art
She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.
"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.
She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)
Keywords: Kangana Ranaut, Thalaivii, bollywood, stretc marks, actress, tamil cinema
The status website says the encrypted messaging app is "experiencing technical difficulties" and many people are also getting an in-app error message that says the same thing. Signal allows for secure and encrypted video, voice and text communication, but users are unable to send any messages.
According to Downdetector.com, users started reporting outages around 11:05 PM Eastern Standard Time and it appears to be affecting people around the world. Comments shared on Downdetector.com indicates that Signal was down for users from India, US, Germany, New Zealand, Netherlands, Australia, Brazil and many other countries.
"Down in Midwest USA. Signal was started by people connected to which secret 3-letter organization? (Look it up) Yep, that's right! An app disguised a privacy app to trick you into sharing more private information than you would with another messaging app," a user said. "I think Signal is having a rough day. Good luck, Team Signal. I'm sure you'll have it sorted out in a snap," said another. The encrypted messaging service has climbed to the top spot in the free apps category of the App Store in multiple countries, including India. (IANS/ MBI)
Keywords: Signal, app, encrypted, messages, outage, down