Never miss a story

Get subscribed to our newsletter


×
One hemisphere of a healthy brain (L) is pictured next to one hemisphere of a brain of a person suffering from Alzheimer disease. VOA

Researchers have identified a new mechanism that may contribute to Alzheimer’s disease and traumatic brain injury, hoping that the discovery may lead to effective treatment.

According to researchers from Rutgers University, the causes of Alzheimer’s is unknown. But a popular theory suggests a protein known as amyloid-beta slowly builds up a plaque in the brains of people with the disease.


The research team looked at a new mechanism, which involves a non-amyloid-beta protein, a potassium channel referred to as KCNB1.

Under conditions of stress in a brain affected by Alzheimer’s, KCNB1 builds up and becomes toxic to neurons and then promotes the production of amyloid-beta. The build-up of KCNB1 channels is caused by a chemical process commonly known as oxidation.


Alzheimer’s disease. Wikipedia

“Indeed, scientists have known for a long time that during aging or in neurodegenerative disease cells produce free radicals,” said co-author Federico Sesti, a professor at the varsity.

“Free radicals are toxic molecules that can cause a reaction that results in lost electrons in important cellular components, including the channels,” Sesti added.

The study, published in the journal Cell Death and Disease, found that in brains affected by Alzheimer’s, the build-up of KCNB1 was much higher compared to normal brains.

“The discovery of KCNB1’s oxidation/build-up was found through observation of both mouse and human brains, which is significant as most scientific studies do not usually go beyond observing animals,” said Sesti.

“Further, KCBB1 channels may not only contribute to Alzheimer’s but also to other conditions of stress as it was found in a recent study that they are formed following brain trauma,” Sesti added.


A lady suffering from Alzheimer’s. Flickr

In the cases of Alzheimer’s and traumatic brain injury, the build-up of KCNB1 is associated with severe damage of mental function. As a result of this discovery, the researcher successfully tested a drug called Sprycel in mice. The drug is used to treat patients with leukemia.

Also Read: A Majority of Children Die Due to Lack of Basic Healthcare Facilities: UN

The research team now hopes to launch a clinical trial to test the treatment in humans. (IANS)


Popular

IANS

Union Finance Minister Nirmala Sitharaman on Saturday asked the Directorate of Revenue Intelligence (DRI) to prevent dumping of toxic wastes in India.

Union Finance Minister Nirmala Sitharaman on Saturday asked the Directorate of Revenue Intelligence (DRI) to prevent dumping of toxic wastes in India. Speaking at an event to celebrate DRI's 64th foundation day, Sitharaman lauded DRI's compact strength of about 800 officers for their relentless efforts despite the imminent risks. The Finance Minister stated that the officers may be keeping a low profile, but they are acting like the frontline defence forces, doing spectacular work in safeguarding the economic frontiers of the country. "The recent smuggling attempts of huge quantities of narcotics, gold, red sanders, ivory, cigarettes etc. unearthed by DRI were appreciated by the Finance Minister," the Ministry of Finance said in a statement.

"Sitharaman said that the message through such enforcement actions should be such that these acts of brazen attempts at smuggling are nipped in the bud," the statement added. The Finance Minister also said that better coordination among the law enforcement and intelligence gathering agencies and sharing of actionable intelligence are the way forward in protecting the frontiers of the country more efficiently. "Sitharaman also asked the DRI to focus on interdicting dual use technology items as well as preventing the dumping of toxic wastes in our country," the statement said. (IANS/ MBI)


Keep Reading Show less
Photo by Brandon Romanchuk on Unsplash

Tech giant Amazon has expanded the sound detection capabilities of Alexa along with more features.

Tech giant Amazon has expanded the sound detection capabilities of Alexa along with more features. Alexa can now identify the sounds of running water and appliances beeping, reports Android Central. This means users can set up an Alexa routine to notify themselves when the washer beeps to indicate that laundry is finished, the report said.

When Alexa detects that the faucet has been left open, it will send users a notification as well so they can take appropriate action, it added. Amazon previously said at its event in September that it would add the ability to programme Alexa to recognise custom sounds, but that feature has yet to arrive. Having said that, the two new sound detection capabilities not only help users save energy, but they also make it easier to avoid paying for unnecessary charges on your home utilities, the report said.

The retail giant has also announced ultrasound motion detection, which will allow you to set up "Occupancy Routines" on additional Echo devices. This feature allows your smart speaker to detect nearby motion and initiate a routine, such as turning on the lights. It is compatible with many of the best Alexa speakers including the 4th-gen Echo, Echo Dot and Echo Dot with Clock. (IANS/ MBI)


Keep Reading Show less
Rawpixel

Comforting Christmas cocktails help you enjoy the celebrations and get into the festive spirit.

By Olivia Sarkar
It's the holiday season, which means it's time to be merry! As the month of December approaches, we're all in a festive mindset. With Christmas just around the corner, there will be plenty of parties and get-togethers with friends and family.

Comforting Christmas cocktails help you enjoy the celebrations and get into the festive spirit. The Leela Palaces, Hotels, and Resorts offer distinctive cocktails ranging from Hot Toddies to Decadent Egg Nogs. Sit back and enjoy one martini at a time to make the festive season a little brighter.

Dirty Chai Eggnog:

Eggnog is a Christmas favorite that is accustomed to toasts for good health and prosperity. It is an American tradition that has spread around the world. Historically, it has been made using eggs, milk, and alcohol. Our culinary artists have given an Indian twist to this winter drink, making it quintessentially desi!



Recipe:

30 ml Bourbon
30 ml Baileys
90 ml Hot milk tea
Whole Spices
Sweet cream foam to top up

Garnish:
Cinnamon powder and star anise.

Keep reading... Show less