Monday July 16, 2018

Any link between Eating Too much of Sugar and Diabetes? Read this to know!

The ChREBP protein is found in several metabolic organs in humans, contributes to the development of both fatty liver and increased glucose production

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Photo for representational purpose. Source: Wikimedia
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October 2, 2016: Excessive sugar consumption — specifically the sugar fructose such as in soda — has been linked to a rise in metabolic disease worldwide, a study has found.

Some investigators contend that commonly consumed amounts of sugar do not contribute to this epidemic. While others are convinced that excessive sugar ingestion is a major cause.

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“There is still significant controversy as to whether sugar consumption is a major contributor to the development of diabetes,” said senior author Mark Herman, Assistant Professor at Duke University.

However, “the study reveals a specific mechanism by which consuming fructose in large amounts, such as in soda, can cause problems”, Herman added.

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Insulin is a key hormone that regulates blood glucose after eating. Insulin resistance, when the body’s metabolic tissues stop responding normally to insulin, is one of the earliest detectable changes in the progression to diabetes.

The likely cause of insulin resistance may not be the build-up of fat in the liver, as commonly believed, but may be caused by excess sugar in the liver that activates a molecular factor known as carbohydrate-responsive element-binding protein, or ChREBP.

ChREBP may then contribute to the development of both fatty liver and increased glucose production, the researchers said.

The ChREBP protein is found in several metabolic organs in mice, humans and other mammals.

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“We found that no matter how much insulin the pancreas made, it couldn’t override the processes started by this protein, ChREBP, to stimulate glucose production. This would ultimately cause blood sugar and insulin levels to increase, which over time can lead to insulin resistance elsewhere in the body,” Herman explained.

To test their hypothesis, researchers studied mice that were genetically altered so their liver insulin signalling pathways were maximally activated — in other words, their livers should not have been able to produce any glucose.

The researchers found that even in these mice, eating fructose triggered ChREBP-related processes in the liver, causing it to make more and more glucose, despite insulin signals telling it to stop.

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Previous studies have reported that high fructose diets can cause multiple metabolic problems in humans and animals, including insulin resistance and fatty liver disease.

The finding could also help scientists one day diagnose metabolic disorders earlier on, potentially allowing patients to make changes to their diets and lifestyles sooner to prevent more serious complications.

The study was published in the Journal of Clinical Investigation.

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  • Antara

    Excessive sugar consumption can become extremely harmful for the liver! Drinking of sodas at least, must be checked.

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FIFA World Cup 2018: Indian Cuisine becomes the most sought after in Moscow

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Indian cuisine in FIFA World cup
Indian dishes available in Moscow during FIFA World Cup 2018, representational image, wikimedia commons

June 17, 2018:

Restaurateurs Prodyut and Sumana Mukherjee have not only brought Indian cuisine to the ongoing FIFA World Cup 2018 here but also plan to dish out free dinner to countrymen if Argentina wins the trophy on July 15.

Based in Moscow for the last 27 years, Prodyut and Sumana run two Indian eateries, “Talk Of The Town” and “Fusion Plaza”.

You may like to read more on Indian cuisine: Indian ‘masala’, among other condiments spicing up global food palate.

Both restaurants serve popular Indian dishes like butter chicken, kebabs and a varied vegetarian spread.

During the ongoing FIFA World Cup 2018, there will be 25 per cent discount for those who will possess a Fan ID (required to watch World Cup games).

There will also be gifts and contests on offers during matches in both the restaurants to celebrate the event.

The Mukherjees, hailing from Kolkata, are die-hard fans of Argentina. Despite Albiceleste drawing 1-1 with Iceland in their group opener with Lionel Messi failing to sparkle, they believe Jorge Sampaoli’s team can go the distance.

“I am an Argentina fan. I have booked tickets for a quarterfinal match, a semifinal and of course the final. If Argentina goes on to lift

During the World Cup, there will be 25 per cent discount for those who will possess a Fan ID (required to watch World Cup games).

There will also be gifts and contests on offers during matches in both the restaurants to celebrate the event.

FIFA World Cup 2018 Russia
FIFA World Cup 2018, Wikimedia Commons.

“We have been waiting for this World Cup. Indians come in large numbers during the World Cup and we wanted these eateries to be a melting point,” he added.

According to Cutting Edge Events, FIFA’s official sales agency in India for the 2018 World Cup, India is amongst the top 10 countries in terms of number of match tickets bought.

Read more about Indian cuisine abroad: Hindoostane Coffee House: London’s First Indian Restaurant.

Prodyut came to Moscow to study engineering and later started working for a pharmaceutical company here before trying his hand in business. Besides running the two restaurants with the help of his wife, he was into the distribution of pharmaceutical products.

“After Russia won the first match of the World Cup, the footfall has gone up considerably. The Indians are also flooding in after the 6-9 p.m. game. That is the time both my restaurants remain full,” Prodyut said.

There are also plans to rope in registered fan clubs of Latin American countries, who will throng the restaurants during matches and then follow it up with after-game parties till the wee hours.

“I did get in touch with some of the fan clubs I had prior idea about. They agreed to come over and celebrate the games at our joints. Those will be gala nights when both eateries will remain open all night for them to enjoy,” Prodyut said.

Watching the World Cup is a dream come true for the couple, Sumana said.

“We want to make the Indians who have come here to witness the spectacle and feel at home too. We always extend a helping hand and since we are from West Bengal, we make special dishes for those who come from Bengal,” she added. (IANS)