Monday May 20, 2019

Any link between Eating Too much of Sugar and Diabetes? Read this to know!

The ChREBP protein is found in several metabolic organs in humans, contributes to the development of both fatty liver and increased glucose production

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Photo for representational purpose. Source: Wikimedia

October 2, 2016: Excessive sugar consumption — specifically the sugar fructose such as in soda — has been linked to a rise in metabolic disease worldwide, a study has found.

Some investigators contend that commonly consumed amounts of sugar do not contribute to this epidemic. While others are convinced that excessive sugar ingestion is a major cause.

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“There is still significant controversy as to whether sugar consumption is a major contributor to the development of diabetes,” said senior author Mark Herman, Assistant Professor at Duke University.

However, “the study reveals a specific mechanism by which consuming fructose in large amounts, such as in soda, can cause problems”, Herman added.

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Insulin is a key hormone that regulates blood glucose after eating. Insulin resistance, when the body’s metabolic tissues stop responding normally to insulin, is one of the earliest detectable changes in the progression to diabetes.

The likely cause of insulin resistance may not be the build-up of fat in the liver, as commonly believed, but may be caused by excess sugar in the liver that activates a molecular factor known as carbohydrate-responsive element-binding protein, or ChREBP.

ChREBP may then contribute to the development of both fatty liver and increased glucose production, the researchers said.

The ChREBP protein is found in several metabolic organs in mice, humans and other mammals.

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“We found that no matter how much insulin the pancreas made, it couldn’t override the processes started by this protein, ChREBP, to stimulate glucose production. This would ultimately cause blood sugar and insulin levels to increase, which over time can lead to insulin resistance elsewhere in the body,” Herman explained.

To test their hypothesis, researchers studied mice that were genetically altered so their liver insulin signalling pathways were maximally activated — in other words, their livers should not have been able to produce any glucose.

The researchers found that even in these mice, eating fructose triggered ChREBP-related processes in the liver, causing it to make more and more glucose, despite insulin signals telling it to stop.

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Previous studies have reported that high fructose diets can cause multiple metabolic problems in humans and animals, including insulin resistance and fatty liver disease.

The finding could also help scientists one day diagnose metabolic disorders earlier on, potentially allowing patients to make changes to their diets and lifestyles sooner to prevent more serious complications.

The study was published in the Journal of Clinical Investigation.

  • Antara

    Excessive sugar consumption can become extremely harmful for the liver! Drinking of sodas at least, must be checked.

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Aadhaar Helpline Mystery: French Security Expert Tweets of doing a Full Disclosure Tomorrow about Code of the Google SetUP Wizard App

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Google comes up with a new feature

Google’s admission that it had in 2014 inadvertently coded the 112 distress number and the UIDAI helpline number into its setup wizard for Android devices triggered another controversy on Saturday as India’s telecom regulator had only recommended the use of 112 as an emergency number in April 2015.

After a large section of smartphone users in India saw a toll-free helpline number of UIDAI saved in their phone-books by default, Google issued a statement, saying its “internal review revealed that in 2014, the then UIDAI helpline number and the 112 distress helpline number were inadvertently coded into the SetUp wizard of the Android release given to OEMs for use in India and has remained there since”.

Aadhaar Helpline Number Mystery: French security expert tweets of doing a full disclosure tomorrow about Code of the Google SetUP Wizard App, Image: Wikimedia Commons.

However, the Telecom Regulatory Authority of India (TRAI) recommended only in April 2015 that the number 112 be adopted as the single emergency number for the country.

According to Google, “since the numbers get listed on a user’s contact list, these get  transferred accordingly to the contacts on any new device”.

Google was yet to comment on the new development.

Meanwhile, French security expert that goes by the name of Elliot Alderson and has been at the core of the entire Aadhaar controversy, tweeted on Saturday: “I just found something interesting. I will probably do full disclosure tomorrow”.

“I’m digging into the code of the @Google SetupWizard app and I found that”.

“As far as I can see this object is not used in the current code, so there is no implications. This is just a poor coding practice in term of security,” he further tweeted.

On Friday, both the Unique Identification Authority of India (UIDAI) as well as the telecom operators washed their hand of the issue.

While the telecom industry denied any role in the strange incident, the UIDAI said that he strange incident, the UIDAI said that some vested interests were trying to create “unwarranted confusion” in the public and clarified that it had not asked any manufacturer or telecom service provider to provide any such facility.

Twitter was abuzz with the new development after a huge uproar due to Telecom Regulatory Authority of India (TRAI) Chairman R.S. Sharma’s open Aadhaar challenge to critics and hackers.

Ethical hackers exposed at least 14 personal details of the TRAI Chairman, including mobile numbers, home address, date of birth, PAN number and voter ID among others. (IANS)

Also Read: Why India Is Still Nowhere Near Securing Its Citizens’ Data?