Friday November 16, 2018

Weight Loss Tip- Chinese Medicine Ingredient May Help Reduce Obesity

Overweight and obesity may increase the risk of many health problems, including diabetes, heart diseases and certain cancers

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Weight Loss
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A herbal ingredient used in traditional Chinese medicines may help you to reduce your body weight, a new study has found.

The scientists were able to show that the herbal active substance, celastrol — used in Chinese medicines — leads to a significant weight loss and an improvement of diabetes in obese mice, Xinhua news agency reported on Saturday.

The findings showed the celastrol specifically activates satiety centres in the brain, which play a central role in the control of body weight.

“Normally, those affected lose their satiety because the corresponding hormone leptin no longer works. The drug celastrol we investigated restores leptin sensitivity and hence satiety,” said lead author Katrin Pfuhlmann from Helmholtz Zentrum Munchen – German Research Centre for Environmental Health.

The study, published in the journal Diabetes, observed a significantly altered eating behaviour in overweight animals.

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“The administration of celastrol resulted in significantly reduced food intake in the mouse model. Accordingly, we were able to determine an average loss of about 10 per cent body weight within a week,” the researchers said.

To what extent the findings can also be confirmed in humans is still unclear, according to the authors. However, study leader Pfluger is confident, “The satiety hormone leptin in humans and the mouse is almost identical, so celastrol has great potential,” the report said.

The clinical trials are currently under way in the US.

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“The satiety hormone leptin in humans and the mouse is almost identical, so celastrol has great potential,” the researcher said.

Overweight and obesity may increase the risk of many health problems, including diabetes, heart diseases and certain cancers. (IANS)

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Genes Tied to Obesity May Lower Risk of Diabetes

"Meanwhile, some lean or normal weight individuals develop diseases like Type-2 diabetes," Yaghootkar noted

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Diabetes
Poor aerobic fitness can up diabetes, heart disease risk in kids. Pixabay

Certain genetic factors may impact our body in intriguingly paradoxical ways. A team of scientists has identified 14 new genetic variations that were linked with higher Body Mass Index (BMI) but have the potential to lower risk of diabetes, lower blood pressure and lower heart disease risk.

According to researchers, it is because the location — around middle or round the liver — where surplus fat is stored could be genetically determined.

This location is more important than the amount when it comes to insulin resistance and risk of diabetes and other conditions.

“There are some genetic factors that increase obesity, but paradoxically reduce metabolic risk. It is to do with where on the body the fat is stored,” said Brunel Alex Blakemore, Professor at the Brunel University London.

The findings revealed that as they gain weight, people who carry these genetic factors store it safely under the skin, and so have less fat in their major organs such as the liver, pancreas and kidneys.

Diabetes
Representational image. Pixabay

“Directly under the skin is better than around the organs or especially, within the liver,” Blakemore added.

For the study, published in the journal Diabetes, the team examined more than 500,000 people aged between 37 and 73.

They used Magnetic Resonance Imaging (MRI) scans of these people’s waists to match where they stored extra fat with whether they showed signs of Type-2 diabetes, heart attack and risk of stroke.

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“There are many overweight or obese individuals who do not carry the expected metabolic disease risks associated with higher BMI,” explained Hanieh Yaghootkar from the University of Exeter in Britain.

“Meanwhile, some lean or normal weight individuals develop diseases like Type-2 diabetes,” Yaghootkar noted. (IANS)