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Consumer Sentiments Appear Weak and Slowdown Persists though Growth Not “Falling Off Cliff”

On the consumer market, it said the distribution is undergoing a change and 'kiranas' are here to stay and they are getting a strong foothold

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Consumer, Slowdown, Growth
"Consumer sentiments appear weak and slowdown persists but growth does not seem to be falling off a cliff," the broking house said in a note. Pixabay

Broking firm HSBC Securities on Thursday said consumer sentiments appear weak and the slowdown persists though growth is not “falling off a cliff”.

“Consumer sentiments appear weak and slowdown persists but growth does not seem to be falling off a cliff,” the broking house said in a note.

On the consumer market, it said the distribution is undergoing a change and ‘kiranas’ are here to stay and they are getting a strong foothold.

Finance Minister Nirmala Sitharaman a day ago in Chennai said though GDP growth has declined to five per cent in the first quarter, ups and down are part of the growth process and the government is responding to the current economic challenges to revive demand and consumption in the country.

Consumer, Slowdown, Growth
Broking firm HSBC Securities on Thursday said consumer sentiments appear weak and the slowdown persists though growth is not “falling off a cliff”. Pixabay

She said the “millennial mindset” of relying on taxi services, besides the upcoming stricter emission norms, are responsible for the auto sector slowdown.

The macro state of economy is such that the muted household spending as reflected in metrics like falling car sales have resulted in unsold inventories. Rising unused capacities in factory plants have shown slackening demand and feeble investment.

Automobile sellers have not been reporting brisk activity, implying lower spending ability and flat income growth. Hundreds of showrooms have shut shop.

Tractor and motorcycle sales – indicators of rural demand – continued to contract.

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Commercial vehicle sales slowed even after adjusting for base effects, beaten by low demand.

Construction activity indicators have also slowed down, with contraction in cement production and slower growth in finished steel consumption in June. (IANS)

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Researchers Identify Key Protein that Spurs Bowel Cancer Growth

Learning more about how Importin-11 transports beta-catenin into the nucleus may help researchers develop new therapies that block this process and reduce the growth of colorectal cancers caused by mutations in APC

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Stroke
The researchers added that future studies could help pinpoint mechanisms and further establish the relationship between cancer and stroke. Pixabay

Researchers have identified a key protein that supports the growth of many bowel cancers, paving the way for development of new therapies to combat the deadly disease.

The study, published in the Journal of Cell Biology, revealed that a protein called Importin-11 transports the cancer-causing protein beta-catenin into the nucleus of colon cancer cells, where it can drive cell proliferation.

Inhibiting this transport step could block the growth of most colorectal cancers — also called bowel cancers — caused by elevated beta-catenin levels.

Around 80 per cent of colorectal cancers are associated with mutations in a gene called APC that result in elevated levels of the beta-catenin protein.

This increase in beta-catenin is followed by the protein’s accumulation in the cell nucleus, where it can activate numerous genes that drive cell proliferation and promote the growth and maintenance of colorectal tumours.

But how beta-catenin enters the cell nucleus after its levels rise is poorly understood.

Gut Bacteria
Researchers have found that people with a certain type of Gut Bacteria may be at a greater risk of developing bowel cancer. Pixabay

“Because the molecular mechanisms underlying beta-catenin nuclear transport remain unclear, we set out to identify genes required for continuous beta-catenin activity in colorectal cancer cells harbouring APC mutations,” said Stephane Angers, Professor at the University of Toronto in Canada.

Using CRISPR DNA editing technology, the researchers developed a new technique that allowed them to screen the human genome for genes that support beta-catenin’s activity in colorectal cancer cells after its levels have been elevated by mutations in APC.

Angers and colleagues found that Importin-11 binds to beta-catenin and escorts it into the nucleus of colorectal cancer cells with mutations in APC. Removing Importin-11 from these cells prevented beta-catenin from entering the nucleus and activating its target genes.

The researchers discovered that Importin-11 levels are often elevated in human colorectal cancers. Moreover, removing Importin-11 inhibited the growth of tumours formed by APC mutant cancer cells isolated from patients.

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“We conclude that Importin-11 is required for the growth of colorectal cancer cells,” Angers said.

Learning more about how Importin-11 transports beta-catenin into the nucleus may help researchers develop new therapies that block this process and reduce the growth of colorectal cancers caused by mutations in APC. (IANS)