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A team of researchers has identified a set of genes that can tell whether people are heading towards healthy aging or not. Accumulation of unrepaired DNA damage has been one of the main causes of aging. These can also lead to neurodegenerative diseases such as Parkinson’s and Alzheimer’s.
The study, published in the journal Ageing, targetted the SIRT6 gene — known to play an instrumental role in DNA repair. The SIRT6 gene was found to have an effect in pathological aging, but not in normal aging, said Debra Toiber, from the Ben-Gurion University of the Negev in Israel. The team also determined which genes are better candidates for targeted therapies and whose damage can be reversed by interventions such as calorie restriction.
“My research for the last several years has focused on unlocking the secrets of SIRT6, which we discovered, plays a number of prominent roles in aging,” Toiber said.
Previous studies show that SIRT6 plays an instrumental role in DNA repair. Its levels were found to decrease in the aging brain. It serves as a first responder in DNA double-strand breaks, immediately going to work but also signaling to other proteins to come help repair the damage.
Since there are many changes in aging and in these pathologies, the researchers compared SIRT6-impaired mice to regular mice, both the same age and compared to older mice. They were able to identify these changes and also find the genes that could predict whether a brain is moving towards healthy aging or pathological aging. (IANS/JC)
Since the 7th of December 1949, the Armed Forces Flag Day has been observed in India, annually. This one day is dedicated towards collection of funds from the citizens of India for the welfare of the ‘Indian Armed Forces personnel’. It has become a tradition to pay respect to the people who have served in the army, Navy and Airforce, on this day.
“The idea behind observing a Flag Day was to distribute small flags to the general population and in return collect donations.” The color-scheme of the flag is very similar to the ones used by fellow Commonwealth members like Cyprus, Kenya and Nigeria. The Flag Day signifies that it is the responsibility of the citizens of India to take care of the families and dependents of the armed forces personnel who fight for the country.
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A need for such a day was realized by the Government after India gained Independence from the British rule. In order to manage the welfare of its defence personnel, the Defence Minister of India and a committee together decided to recognize 7th December as the Flag Day. This decision was taken on the 28th of August 1949.
The then Prime Minister Jawaharlal Nehru inaugurated the day saying that,
“A few weeks ago, I visited Indo-China and saw our officers and men attached to the International Commission there. It gave me a thrill to see their smart bearing and the good work they were doing in that distant land. What pleased me still more was their general popularity with the people there. By their efficiency as well as their friendliness, they enhanced the reputation of India. Among them were people from all parts of India. They observed no provincial or other differences amongst themselves. I am sure my countrymen will be pleased to learn of them and would like to indicate their appreciation of these young men who serve our country both here and elsewhere so well. A way to indicate that appreciation is to contribute to the Flag Day Fund.”
The fund is collected through official and non-official means with the help of voluntary organizations. The Kendriya Sainik Board, which is under the Ministry of Defence, arranges for the collection of the fund.
The Defence Ministry of India decided to integrate all the related welfare funds into a single unit called the Armed Forces Flag Day fund. The funds that were integrated are:
- Amalgamated Special Fund for War Bereaved, War Disabled and other ex-Servicemen/Serving Personnel
- Flag Day Fund
- St Dunstan's (India) and Kendriya Sainik Board Fund
- Indian Gorkha Ex-Servicemen's Welfare Fund
The Flag Day signifies that it is the responsibility of the citizens of India to take care of the families and dependents of the armed forces personnel who fight for the country.Unsplash
Problems have to be resolved by and welfare of the ex-servicemen and dependents are mostly settled by the States and the Union Territories, although it was to be a shared responsibility between the Union Government, the State Governments and the governments of the Union Territories. In order to help the Central Government in carrying out this process, there are 32 Rajya Sainik Boards and 392 Zila Sainik Boards. The Kendriya Sainik Board, the Rajya Sainik Board and the Zila Sainik Board are all responsible for the policy formulation and implementation of resettlement and welfare schemes for ex-servicemen, widows and their dependents residing in their respective States or Union Territories or Districts.(Keywords : armed, forces, flag, india, independance, donation, citizen, army, navy, airforce, tradition, respect, government, state, center, union territory, district, funds.)
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A large majority of Indians seem convinced that social media is responsible for the increased gulf between the Hindu and Muslim communities in the country.
This was revealed by a nationwide poll conducted by IANS-CVoter with a sample size of 1942 using random sampling on December 5, one day before the beginning of the 30th anniversary of the demolition of Babri Masjid on December 6, 1992.
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Close to half the respondents surveyed, 48.2 per cent to be precise felt that social media had increased the gulf between the communities to a large extent.
About 23 per cent of the respondents felt that social media had increased the gulf to some extent. In effect, more than 71 per cent Indians hold social media responsible for the recent friction between the two communities.
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In contrast, 28.6 per cent were of the opinion that social media had no role to play in this phenomenon. If you look at political divides, 40.7 per cent of NDA voters felt social media was responsible to a large extent while 53.6 per cent of opposition voters felt the same.
48.2 per cent to be precise felt that social media had increased the gulf between the communities to a large extent.Unsplash
Social media platforms have come under increased scrutiny of late for their alleged role in spreading misinformation, fake news, abusive and defamatory content and direct incitement to violence. It has become routine for state and local level administrations to temporarily ban access to social media platforms in areas that report tension and fears of violence.
A parliamentary committee has recently submitted a set of recommendations to regulate social media platforms. One major recommendation is to treat them as publishers while the other is to form a regulatory body on the lines of Press Council of India to regulate their activities. (IANS/SP)
(Keywords : social media, Hindu, Muslim, community, country, poll, respondents, political, religious, misinformation, violence. abuse, regulations)
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Final preparations are in full swing at Six Senses Fort Barwara which will host the much talked about wedding of celebrity couple Vicky Kaushal and Katrina Kaif.
According to sources, the event company working for this wedding has procured crystal balls and chandeliers from abroad to give a royal look to the wedding. These will be installed in the hotel soon.
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Six Senses Hotel has also parked indicator vehicles on the road at frequent intervals for the guests to reach the hotel easily. A glass 'mandap' has been prepared and decorated in Rajwada style for the couple to take 'pheres' (rounds around the fire) as per Hindu rituals. Moreover, the glass carvings on the mandap is such that it creates an optical illusion.
This wedding ceremony will be held amidst tight security arrangements. Secret codes have been given to each of the guests, so that it is impossible to know which guest is staying in which room.
Mobile phones have been banned inside the venue. International photographers have been hired to shoot the entire wedding. The ceremonies will be held from December 7 to December 9, with bouncers and police personnel looking after the security arrangements. As many as 100 bouncers have arrived from Jaipur to look after security arrangements at the wedding.
Katrina and Vicky's wedding is to be solemnized on December 9.Unsplash
Vicky Kaushal and Katrina Kaif's outfits have been designed in Mumbai which they will wear during different wedding ceremonies.
As per information, Katrina Kaif and Vicky Kaushal are scheduled to reach Hotel Six Senses Fort Barwara located at Chauth Ka Barwara, by 9 p.m. on Monday, via car from Jaipur where both are expected to receive a grand welcome by the hotel management.
Along with Vicky and Katrina, their family members too will reach the hotel on Monday. However, some close family members and other guests will reach the venue separately. Katrina's sister Natasha and friends reached Jaipur airport on Monday afternoon from where they left for the wedding venue by car.
Katrina and Vicky's wedding is to be solemnized on December 9. (IANS/SP)
(Keywords : wedding, Bollywood, Vicky Kaushal, Katrina Kaif, Rajasthan, hotel, Fort Barwara, ceremony, photographer, bouncer, outfit)
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