Monday January 20, 2020

Researchers Examine Patterns of Back Pain

The bad news is that one in five experienced persistent back pain, said Canizares

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Researchers study patterns of back pain. IANS

Researchers have examined the patterns of back pain over time and patient characteristics in relation to the disability.

In addition, they have identified the extent of healthcare and medication use (including opioids) associated with different patterns.

Back pain is among the most frequently reported health problems in the world.

For the study, researchers from the University Health Network’s Krembil Research Institute in Toronto, Canada studied 12,782 participants for 16 years.

They provided data on factors including comorbidities, pain, disability, opioid and other medication use, and healthcare visits.

The results showed that almost half (45.6 per cent) of the participants reported back pain at least once.

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The study included four groups of pain: persistent (18 per cent), developing (28.1 per cent), recovery (20.5 per cent), and occasional (33.4 per cent).

The findings, published in Arthritis Care and Research, showed that the persistent and developing groups tended to have more pain and disability, as well as more healthcare visits and medication use than those in the recovery and occasional trajectory groups.

In addition, the recovery trajectory group increased the use of opioids and antidepressants over time.

“The good news is that one in five people with back pain recovered. However, they continued to use opioids and antidepressants, suggesting that people recovering from back pain need ongoing monitoring,” said lead author Mayilee Canizares, postdoctoral candidate from the varsity.

The bad news is that one in five experienced persistent back pain, said Canizares.

People with back pain are a heterogeneous group that may benefit from different approaches to management rather than a traditional one size fits all approach. The distinct groups identified in the study may represent opportunities for more individualised treatment and preventative strategies, Canizares noted. (IANS)

Next Story

Researchers Develop Machine Keeping Human Livers Alive For a Week Outside Body

The next step will be to use these organs for transplantation. The proposed technology opens a large avenue for many applications offering a new life for many patients with end stage liver disease or cancer

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The study shows that six of ten perfused poor-quality human livers, declined for transplantation by all centres in Europe, recovered to full function within one week of perfusion on the machine. Pixabay

Researchers have developed a machine that repairs injured human livers and keeps them alive outside the body for one week.

According to the study, published in the journal Nature Biotechnology, this breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer.

“The success of this unique perfusion system — developed over a four-year period by a group of surgeons, biologists and engineers — paves the way for many new applications in transplantation and cancer medicine helping patients with no liver grafts available,” said study researcher Pierre-Alain Clavi from the University Hospital Zurich in Switzerland.

Until now, livers could be stored safely outside the body for only a few hours. With the novel perfusion technology, livers — and even injured livers — can now be kept alive outside of the body for an entire week.

This is a major breakthrough in the transplantation medicine, which may increase the number of available organs for transplantation and save many lives of patients suffering from severe liver diseases or a variety of cancers.

Injured cadaveric livers, initially not suitable for use in transplantation, may regain full function while perfused in the new machine for several days.

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According to the study, published in the journal Nature Biotechnology, this breakthrough may increase the number of available organs for transplantation saving many lives of patients with severe liver diseases or cancer. Pixabay

According to the researchers, the basis for this technology is a complex perfusion system, mimicking most core body functions close to physiology.

The Liver4Life project was developed under the umbrella of Wyss Zurich institute, which brought together the highly specialised technical and biomedical knowledge of experts from the University Hospital Zurich.

“The biggest challenge in the initial phase of our project was to find a common language that would allow communication between the clinicians and engineers,” said researcher Philipp Rudolf von Rohr.

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The study shows that six of ten perfused poor-quality human livers, declined for transplantation by all centres in Europe, recovered to full function within one week of perfusion on the machine.

The next step will be to use these organs for transplantation. The proposed technology opens a large avenue for many applications offering a new life for many patients with end stage liver disease or cancer. (IANS)