London, Altering a single gene has helped scientists create super intelligent mice and researchers believe that the findings could lead to new drugs for cognitive disorders such as Alzheimer’s disease, schizophrenia and other conditions.
The researchers altered the gene to inhibit the activity of an enzyme called phosphodiesterase-4B (PDE4B), which is present in many organs, including the brain.
In behavioral tests, these mice showed enhanced cognitive abilities.
“Cognitive impairments are currently poorly treated, so I am excited that our work using mice has identified phosphodiesterase-4B as a promising target for potential new treatments,” said lead researcher Steve Clap cote, lecturer in pharmacology at the University of Leeds in England.
The findings are limited to mice and have not been tested on humans, but PDE4B is present in humans, the study pointed out.
In tests, the “brainy mice” showed a better ability than ordinary mice to recognize another mouse that they had been introduced to the day before. They were also quicker at learning the location of a hidden escape platform in a test called the Morris water maze.These intelligent mice were also found to be less fearful.
The researchers are now working on developing drugs that will specifically inhibit the enzyme. These drugs will be tested in animals to see whether any would be suitable for clinical trials in humans.
“In the future, medicines targeting PDE4B may potentially improve the lives of individuals with neurocognitive disorders and life-impairing anxiety, and they may have a time-limited role after traumatic events,” co-lead researcher Alexander McGirr, psychiatrist in training at the University of British Columbia in Canada noted.
The findings appeared in the journal Neuropsychopharmacology.
“This is the first controlled trial to precisely determine an anatomically defined brain area where high frequency magnetic pulses can improve the hearing of voices,” said lead researcher Sonia Dollfus, Professor at Centre Hospitalier Universitaire de Caen in France.
Schizophrenia is a serious long-term mental health problem. People with schizophrenia experience a range of symptoms, which may include delusions, muddled thoughts and hallucinations.
One of the best-known is hearing voices, also known as Auditory Verbal Hallucination (AVH), which around 70 per cent of people with schizophrenia experience at some point.
These voices, may be ‘heard’ as having a variety of different characteristics, for example as internal or external, friendly or threatening, they may be continuously present or present only occasionally, and so on.
Transcranial Magnetic Stimulation (TMS), which uses magnetic pulses to the brain, has been suggested as a possible way of treating the hearing of voices in schizophrenia.
However, there is a lack of controlled trials to show that TMS works effectively in treating “hearing of voices”.
The French research team worked with a small group of patients who received active TMS treatment. A control group received sham (placebo) treatment.
The researchers interviewed the patients using a standard protocol — the Auditory Hallucinations Rating Scale — which revealed most of the characteristic features of the voices which they were hearing.
The treated patients received a series of 20 Hz high-frequency magnetic pulses over two sessions a day for two days.
Using magnetic resonance imaging (MRI), the pulses were targetted at a specific brain area in the temporal lobe, which is associated with language.
After two weeks, the patients were re-evaluated. The researchers found that 34.6 per cent of the patients being treated by TMS showed a significant response, whereas only 9.1 per cent of patients in the sham group responded. (IANS)
Alzheimer is a progressive cognitive disorder that destroys memory and other important mental function
In the initial stage memory loss is mild but with the time it gets worse and also causes death
There is no current cure for this but studies show certain yoga postures and natural foods can prevent from dementia and memory loss
July 28, 2017: Today, in the modern era memory loss is growing rapidly not only in the elderly man and women but in children too. Memory loss preceded to Alzheimer’s disease.
Alzheimer is the most common form of dementia, that is used for memory loss. There are common traits at the first stage of disease memory loss is mild like, now in this lifestyle, everyone is finding their self-forgetting appointments, important works, and dates, and other things, remembering faces but not names. As a result, it further leads to forgetting conversations, and respond to their particular environment.
Alzheimer is the sixth leading cause of death in the US. And more than 10 million causes per year (India). After this disease, a patient only can survive for an average of eight years.
According to a study organized by a group of scientists, according to the age, the body changes its shape and starts working at a slow pace. Similarly, our brain also seems to change its shape and starts working in different ways, in which the person gets affected by dementia and Alzheimer’s.
Until a few years ago, this memory deficiency and illness were common among the elderly people who were over 40 but now it is happening to people of all ages.
Currently no definite treatment is possible, but scientists and doctors are researching. And also what we know today, about ninety percent of Alzheimer’s has been discovered in the only last 15 years.
But here you do not need to worry, you can give your memory a power boost at any age that also naturally. With the help of yoga and natural foods.
“While practicing yoga, you focus on your breathing and are completely aware of your postures.” said by author Neha Gothe, at the University of Illinois.
According to Kristine kaoverii Weber, founder of Subtle Yoga “yoga postures seem to affect the way of thinking and reduces anxiety, stress, and it also leads to better cognitive performance.”
A research suggests that if you have practiced yoga for a long time, then you automatically tend to use of your left forebrain. There is more “gray matter” in the left forebrain and therefore, it is a reason, why positive thinking gets affected. Yoga stimulates the left forebrain and helps one to create positive and happy thoughts which in result magnifies your memory and concentration power.
Yoga Postures Which Will Improve Your Memory & Prevent You From Alzheimer:
According to study conducted by Thomas Jefferson medical college in Philadelphia and the yoga research society, there are approximately 100 billion neurons works in brain actively and most are influenced by seretonin hormone. And yoga helps the brain release serotonin naturally.
A 50 minute yoga session performed for 7 days which includes these postures will significantly reduce the cortisol level that prevents you from Alzheimer (or prevent your brain from the pressure of anxiety and stress).
Padmasana: This Yoga posture will prevent you from alzheimer
Padmasana also known as Lotus Position: is a cross-legged sitting asana originating in meditative practices of ancient India, in which the feet are placed on the opposing thighs. It is an asana, commonly used for meditation in the Yoga.
Padahastasana: This Yoga posture will prevent you from alzheimer
Padahastasana or the Hand Under Foot pose is a ‘forward bend asana’. … Padahastasana strengthens the muscles of the limbs as well as the core and promotes good form which is why it is one of the most commonly recommended yoga postures for people who are interested in overall fitness and muscle flexibility.
Sarvangasana:This Yoga posture will prevent you from alzheimer.
Sarvangasana or shoulder stand is a yoga pose wherein the whole body is balanced on the shoulders. It is also a part of the Padma Sadhana yoga sequence.
Paschimottanasana: This Yoga posture will prevent you from alzheimer
Paschimottanasana is known as ( Seated Forward Bend Pose). Helps in Alzheimer & boost memory. Try to touch your head to your both knees as shown in above image.
Tadasana: This Yoga posture will prevent you from alzheimer
There are 5 foods that prevent Alzheimer and boost your memory too.
1. Omega- 3 fatty acids
Daily contain omega 3 s in your diet it can less 26% risk of having a brain disorder that causes Alzheimer.
Omega 3 s is a fatty acid that helps brain to stay in its original shape. For getting omega fatty acids you can add fish (salmon, herring, or White tuna), flax seeds, olive oil once a week in your diet.
2. Curry powder : Will prevent you from alzheimer
Curry is used extensively in Indian food and in some other countries too. Research shows, the incidence of Alzheimer’s is lower in these places than western nations.
A prime ingredient in Curry powder is turmeric. In turmeric, there is a chemical compound curcumin found that helps the brain to intake a high amount of oxygen that regulate the balance of blood circulation in the brain. Studies have shown that, people who consumed the highest amount of curried foods have better brain activity, and concentration power.
3. Green, leafy vegetables: can cure Alzheimer
According to new research, getting regular green, leafy vegetables like- spinach, broccoli, kale, Swiss chard can help keep dementia away. Those who ate green leafy vegetables at one or twice a day have less mental disorders and deterioration than those who ate no vegetables. Green leafy vegetables loaded with vitamin A and K those helps in higher verbal episodic memory performance.
4. Avocados can also cure alzheimer
This fruit is a green powerhouse and is loaded with monosaturated fats or the “good” kind, keeping blood sugar levels steady and it contains both vitamin A and folate. Avocados help prevent blood clots in the brain as well as help improve cognitive function, especially both memory and concentration.
5. Walnuts Boosts Memory.
The shape of the walnuts is exactly like the brain, then by eating nut, the inactivity of the brain ends and the brain can help with the formation of strong and new cells. Just munching on a few walnuts a day can improve your cognitive health.
Person-centred activities combined with just one hour a week of social interaction will be very helpful for people with dementia living in care homes
This trial was conducted with more than 800 participants living with dementia across 69 care homes in South London, North London and Buckingham-shire
Also, this particular approach saved money in comparison with the standard care
Washington DC, July 17, 2017: According to a recent survey, quality of life can be improved and agitation can be reduced, while saving money, for people with dementia living in care homes with the help of person-centred activities combined with just one hour a week of social interaction.
The University of Exeter, King’s College London and Oxford Health NHS Foundation Trust led the findings from a large-scale trial that were presented at the Alzheimer’s Association International Conference 2017 (AAIC).
This trial was conducted with more than 800 participants living with dementia across 69 care homes in South London, North London and Buckingham-shire. The study involved two ‘care staff champions’ at each home who were trained over four day-long sessions, to take simple measures that such as involve talking to residents about their interests and decisions around their own care. When combined with just one hour a week of social interaction, it improved quality of life and reduced agitation.
Also, this particular approach saved money in comparison with the standard care. Researchers believe that the next key challenge is to roll the programme to the 28,000 care homes in the UK that will benefit the lives of the 300,000 people with dementia living in these facilities.
According to ANI report, the lead researcher in the project, Clive Ballard said that people with dementia who are living in care homes can be considered among the most vulnerable in our society. “Incredibly, of 170 carer training manuals available on the market, only four are based on evidence that they really work. Our outcomes show that good staff training and just one hour a week of social interaction significantly improves quality of life for a group of people who can often be forgotten by society,” she added.
Doug Brown, Director of Research for Alzheimer’s Society, feels that 70% of people living in care homes suffer from dementia. That is why it is necessary for the staff to have the right training to provide the best quality dementia care.
– prepared by Durba Mandal of NewsGram. Twitter @dubumerang