Thursday April 19, 2018

India and Africa are the next Destination for Malaria Parasites: Study

Sri Lanka is supposed to be malaria-free and it too should start worrying.

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Malaria, Wikimedia
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Bengaluru, Feb 3, 2017: Detection of malaria parasites resistant to the front line artemisinin (ART) combination therapy in some south Asian countries should worry India, Govindarajan Padmanabhan a top biochemist and malaria researcher at the Indian Institute of Science here has warned.

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Africa and India can as well be the superbug’s next destination and, if it spreads, this will pose a disaster, Padmanabhan told this correspondent, adding: Sri Lanka is supposed to be malaria-free and it too should start worrying.

The British journal Lancet Infectious Diseases had recently reported that P. falciparum malaria parasites resistant to both ART and its widely used partner drug, piperaquine, are now spreading quickly throughout western Cambodia, southern Laos and northeastern Thailand.

The study, by researchers at Mahidol University in Thailand and Oxford University, warned that the consequences of resistance spreading further into India and Africa could be grave if drug resistance is not tackled from a global public health emergency perspective.

Artemisinin, also known as qinghaosu — extracted from the Artemisia annua plant — is a powerful and perhaps the only really effective anti-malarial at present. But because ART has a very short half-life, the World Health Organisation had insisted that it should only be used as a combination with another long-acting anti-malarial.

Thus came the combination therapies: ART-lumefantrine, ART-meflaquine, ART- Sulfadoxine/pyrimethamine (ART-SP) and Dihydroartemisinin-piperaquine (DHA-PPQ).

Padmanabhan said that over the years, the malaria parasite had developed resistance even to many combination therapies, except DHA-PPQ, that had remained very effective.

Now the recent report of the parasite’s resistance to this combination also is really worrisome.

The spread of resistance will be a huge challenge to health workers, he said. This challenge will always go on and that is why I really want to try ART-curcumin combination, which may be an answer to resistance development, the scientist noted.

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Curcumin, is the compound that gives turmeric (haldi) its trademark bright yellow colour.

The ART-curcumin combination is unique, with potential advantages over the known combination therapies, Padmanabhan said. In trials carried out on mice, three oral doses of curcumin following a single injection of artemisinin to infected mice were able to ensure almost 100 per cent survival of the animals.

In addition to having a direct killing effect as an anti-malarial, curcumin is also able to prime the immune system against malaria parasites in mice rendering the combination to act like a therapeutic vaccine, Padmanabhan said.

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Thus, this combination has unique potential to prevent parasite recrudescence and relapse. Besides it is cheap and no resistance against it is known since it is a dietary supplement.

Padmanaban and his team are hoping to start human trials of an artemisinin-curcumin combination therapy in both simple malaria cases and in the treatment of the deadly cerebral malaria. He said regulatory clearances are awaited.

(IANS)

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Shoot The Rapist At The Sight

 And which type is contributing more dangerously to the society can easily be measured with our simple plus and minus equation

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This glaring aberration in the world of media is visible as clearly as stars in the darkness of the night.
India is plagued with a disease called Rape. Wikimedia Commons

Salil Gewali

  • India is plagued with a disease called Rape
  • There are no rigorous punishments for rape
  • Rapists openly commit crimes without anny fear

Why the clamour only for the rigorous punishment for rape and other sadistic crimes which have their roots in the mental-degeneration? Apart from the toughest punishment to the perpetrators, let’s go deeper to analyze what could be the possible  “causes”  that push men to commit rape. Why so much mental degeneration that certain individuals can stoop to the gutter being to their status, their position and social values? Well, how to address those issues is certainly a challenge. And that “challenge” certainly calls for a serious brain-storming and a serious self-assessment vise-a vise the environment in which we all are living.

Ranaghat Nun Rape Case
Rape culture in India garnered more spotlight following the Nirbhaya-gang rape, after which the issue has continue to remain a burning topic in the country. Pixabay

True, in the physical world we are highly convinced brag about that healthy environment is a must for our healthy living. Even kids know these days that we can’t breathe well if our surroundings are filled with high levels of  “toxicity”. We have well studied through our academic textbooks that people invite the environmental disaster if they keep on allowing excessive emission of CO2, CO, methane and other dangerous gases into the atmosphere. We have fully acknowledged that each tall and black chimney of the industries and the nozzles of the motor vehicles are here only to mar the beauty of this planet? What kind of damages the toxic gases are doing to our ecosystem are not at all tough job to analyze with modern appliances. Again, a lot amount of books have been published to create the awareness, to inform us about the scientifically tested measures to resolve the environmental concerns.

However, do we have the same amount of literature that pinpoint the “causes” which contribute to turning “males into perverts”? Who else is emitting the “toxic substances” that overpower the inborn sensitivity of the deviant? What are the properties of toxic filth that is polluting the mind-scape of the society? Now we have Donald Trump, the president of the USA, whom many prefer call him a pervert. At this rate, the number perverts are increasing and they have become dangerously ubiquitous. And, all those perverts have brought nightmares to the ill-fated females. We often stage candle march in protest against the rape, but remain blind to the glaring “causes”. Should we still fiddle about and be appreciative of the society that shameless covers itself with the vulgarity — the “toxicity” that might numb the sanity of males? Watch out, dear friends, those perverts have begun to see even “baby girls” as objects of lust!

Please note:  what our sages said:  “What you see that you think, what you think that you do and what you do that become !!!!”

Also Read: Eat Grapes To Ward Off Depression

Again, I would like to draw another similarity with what prompt big people to “rape”/violate the harmony of the Mother Earth. The case is very regularly brought out by the conscious citizens across the country. A senior journalist Patricia Mukhim of Meghalaya has pointedly driven home recently how the “greed for money” has corrupted many leaders who are trying hard to justify the senseless exploitation of the “body” of Mother Earth. Many big shots of big companies struggle to convince the politicians to tweak the laws to grant the permission to perpetually “rape” the country.

In my mind, both are infected with common syndromes! While the one type is interested in the body of the females, the other type has a fetish for the rocky body of the “Mother Earth”. And which type is contributing more dangerously to the society can easily be measured with our simple plus and minus equation.

The rape victims are not getting the justice they deserve.
The rape victims are not getting the justice they deserve.

Let’s assess the issues from another angle, given the advancement of medical science. Till some years back malaria, dengue, cholera, HIV, smallpox were life-taking diseases. But the medical science has pretty successfully eradicated or contained them all. The scientists have correctly identified the causes of those dangerous diseases and recommended the remedial measures. No doubt, that is a very productive achievement. However, why have the modern studies practically failed to “identify the causes”  of the pandemic rise of the horrendous instances of rapes and criminality associated with them? Is it not a strong slap in the face of the modern civilization considering we have not yet spelt out the causes and the characteristic symptoms the  “toxic emitters” who turn decent males into sadists? How long will we endure the depravity which has already strangulated the decency of the society? Should we still wait to work out the tough laws? Should we still hitch to explore for the “causes” and remedial measures? I guess the time is ripe that each morally conscious individual be allowed a shotgun to shoot the “perversion and depravity” of any kind at sight!

Salil Gewali is a well-known writer and author of ‘Great minds on India’. Twitter: @SGewali.