New York: Giving the search for Alzheimer’s therapies a shot in the arm, researchers have identified the steps that a molecule takes to protect the brain from toxic effects of protein fragments known as amyloid beta, a hallmark of the progressive brain disorder.
“Our discovery centers on a protein called WAVE1, which we found to be important in the production of amyloid beta,” said study author Paul Greengard, professor at Rockefeller University in New York.
“The reduction of WAVE1 appears to have a protective effect against the disease,” Greengard noted.
Brain cells themselves make amyloid beta, and for reasons that are not fully understood, its accumulation ultimately contributes to the memory loss, personality changes, and other symptoms that patients with this degenerative disease often suffer from.
“When levels of amyloid beta rise, there is an accompanying increase in another molecule, AICD, which reduces the expression of WAVE1. This has the effect of reducing the production of amyloid beta,” Greengard explained.
“By targeting steps within this newly discovered pathway, it may be possible to develop drugs to reduce amyloid beta that potentially could be used to either treat or prevent Alzheimer’s disease,” Greengard pointed out.
WAVE1 is known to help to build filaments of a protein called actin that serve as basic components of cellular structures.
In the current study, the team, examined the levels of WAVE1 in mouse and cellular models of Alzheimer’s disease.
They found a dose-dependent response: Mice brains with low WAVE1 levels produced less amyloid-?, and these animals performed better on memory tests.
Alzheimer is a progressive cognitive disorder that destroys memory and other important mental function
In the initial stage memory loss is mild but with the time it gets worse and also causes death
There is no current cure for this but studies show certain yoga postures and natural foods can prevent from dementia and memory loss
July 28, 2017: Today, in the modern era memory loss is growing rapidly not only in the elderly man and women but in children too. Memory loss preceded to Alzheimer’s disease.
Alzheimer is the most common form of dementia, that is used for memory loss. There are common traits at the first stage of disease memory loss is mild like, now in this lifestyle, everyone is finding their self-forgetting appointments, important works, and dates, and other things, remembering faces but not names. As a result, it further leads to forgetting conversations, and respond to their particular environment.
Alzheimer is the sixth leading cause of death in the US. And more than 10 million causes per year (India). After this disease, a patient only can survive for an average of eight years.
According to a study organized by a group of scientists, according to the age, the body changes its shape and starts working at a slow pace. Similarly, our brain also seems to change its shape and starts working in different ways, in which the person gets affected by dementia and Alzheimer’s.
Until a few years ago, this memory deficiency and illness were common among the elderly people who were over 40 but now it is happening to people of all ages.
Currently no definite treatment is possible, but scientists and doctors are researching. And also what we know today, about ninety percent of Alzheimer’s has been discovered in the only last 15 years.
But here you do not need to worry, you can give your memory a power boost at any age that also naturally. With the help of yoga and natural foods.
“While practicing yoga, you focus on your breathing and are completely aware of your postures.” said by author Neha Gothe, at the University of Illinois.
According to Kristine kaoverii Weber, founder of Subtle Yoga “yoga postures seem to affect the way of thinking and reduces anxiety, stress, and it also leads to better cognitive performance.”
A research suggests that if you have practiced yoga for a long time, then you automatically tend to use of your left forebrain. There is more “gray matter” in the left forebrain and therefore, it is a reason, why positive thinking gets affected. Yoga stimulates the left forebrain and helps one to create positive and happy thoughts which in result magnifies your memory and concentration power.
Yoga Postures Which Will Improve Your Memory & Prevent You From Alzheimer:
According to study conducted by Thomas Jefferson medical college in Philadelphia and the yoga research society, there are approximately 100 billion neurons works in brain actively and most are influenced by seretonin hormone. And yoga helps the brain release serotonin naturally.
A 50 minute yoga session performed for 7 days which includes these postures will significantly reduce the cortisol level that prevents you from Alzheimer (or prevent your brain from the pressure of anxiety and stress).
Padmasana: This Yoga posture will prevent you from alzheimer
Padmasana also known as Lotus Position: is a cross-legged sitting asana originating in meditative practices of ancient India, in which the feet are placed on the opposing thighs. It is an asana, commonly used for meditation in the Yoga.
Padahastasana: This Yoga posture will prevent you from alzheimer
Padahastasana or the Hand Under Foot pose is a ‘forward bend asana’. … Padahastasana strengthens the muscles of the limbs as well as the core and promotes good form which is why it is one of the most commonly recommended yoga postures for people who are interested in overall fitness and muscle flexibility.
Sarvangasana:This Yoga posture will prevent you from alzheimer.
Sarvangasana or shoulder stand is a yoga pose wherein the whole body is balanced on the shoulders. It is also a part of the Padma Sadhana yoga sequence.
Paschimottanasana: This Yoga posture will prevent you from alzheimer
Paschimottanasana is known as ( Seated Forward Bend Pose). Helps in Alzheimer & boost memory. Try to touch your head to your both knees as shown in above image.
Tadasana: This Yoga posture will prevent you from alzheimer
There are 5 foods that prevent Alzheimer and boost your memory too.
1. Omega- 3 fatty acids
Daily contain omega 3 s in your diet it can less 26% risk of having a brain disorder that causes Alzheimer.
Omega 3 s is a fatty acid that helps brain to stay in its original shape. For getting omega fatty acids you can add fish (salmon, herring, or White tuna), flax seeds, olive oil once a week in your diet.
2. Curry powder : Will prevent you from alzheimer
Curry is used extensively in Indian food and in some other countries too. Research shows, the incidence of Alzheimer’s is lower in these places than western nations.
A prime ingredient in Curry powder is turmeric. In turmeric, there is a chemical compound curcumin found that helps the brain to intake a high amount of oxygen that regulate the balance of blood circulation in the brain. Studies have shown that, people who consumed the highest amount of curried foods have better brain activity, and concentration power.
3. Green, leafy vegetables: can cure Alzheimer
According to new research, getting regular green, leafy vegetables like- spinach, broccoli, kale, Swiss chard can help keep dementia away. Those who ate green leafy vegetables at one or twice a day have less mental disorders and deterioration than those who ate no vegetables. Green leafy vegetables loaded with vitamin A and K those helps in higher verbal episodic memory performance.
4. Avocados can also cure alzheimer
This fruit is a green powerhouse and is loaded with monosaturated fats or the “good” kind, keeping blood sugar levels steady and it contains both vitamin A and folate. Avocados help prevent blood clots in the brain as well as help improve cognitive function, especially both memory and concentration.
5. Walnuts Boosts Memory.
The shape of the walnuts is exactly like the brain, then by eating nut, the inactivity of the brain ends and the brain can help with the formation of strong and new cells. Just munching on a few walnuts a day can improve your cognitive health.
Person-centred activities combined with just one hour a week of social interaction will be very helpful for people with dementia living in care homes
This trial was conducted with more than 800 participants living with dementia across 69 care homes in South London, North London and Buckingham-shire
Also, this particular approach saved money in comparison with the standard care
Washington DC, July 17, 2017: According to a recent survey, quality of life can be improved and agitation can be reduced, while saving money, for people with dementia living in care homes with the help of person-centred activities combined with just one hour a week of social interaction.
The University of Exeter, King’s College London and Oxford Health NHS Foundation Trust led the findings from a large-scale trial that were presented at the Alzheimer’s Association International Conference 2017 (AAIC).
This trial was conducted with more than 800 participants living with dementia across 69 care homes in South London, North London and Buckingham-shire. The study involved two ‘care staff champions’ at each home who were trained over four day-long sessions, to take simple measures that such as involve talking to residents about their interests and decisions around their own care. When combined with just one hour a week of social interaction, it improved quality of life and reduced agitation.
Also, this particular approach saved money in comparison with the standard care. Researchers believe that the next key challenge is to roll the programme to the 28,000 care homes in the UK that will benefit the lives of the 300,000 people with dementia living in these facilities.
According to ANI report, the lead researcher in the project, Clive Ballard said that people with dementia who are living in care homes can be considered among the most vulnerable in our society. “Incredibly, of 170 carer training manuals available on the market, only four are based on evidence that they really work. Our outcomes show that good staff training and just one hour a week of social interaction significantly improves quality of life for a group of people who can often be forgotten by society,” she added.
Doug Brown, Director of Research for Alzheimer’s Society, feels that 70% of people living in care homes suffer from dementia. That is why it is necessary for the staff to have the right training to provide the best quality dementia care.
– prepared by Durba Mandal of NewsGram. Twitter @dubumerang
New Delhi: Sleep is said to take one-third of our life. And there must be a good reason why nature makes us sleep for this long. A large number of studies all over the world has shown the beneficial effects of good sleep.
Sleep deprivation, on the other hand, results in impairment of judgement, depression, heart problems, obesity and a drastic reduction in the general well-being of an individual. In an extreme case, sleep deprivation has also resulted in death through heart failure. In fact, the first sign of sickness is fretful sleep.
How lack of sleep produces ill health has remained a mystery. Now, slowly, scientific investigations are solving this puzzle.
One of the accepted theories so far has been that sleep helps in both consolidation and removal of memories. We perceive the world during the day through our senses and it results in memory formation both shallow and deep. Sleep, it seems, helps in consolidating and removing some of these memories uncluttering the brain.
Another recent, but fascinating, theory (backed with experiments) has shown that sleep helps in flushing out toxic protein waste and biological debris from the brain, formed during waking hours. It seems that during sleep the relaxation of the brain helps in opening up the channels through which the debris flows into the blood streams and is removed from it.
Studies have also shown that sleep helps flush out harmful protein plaque (beta amyloid) which is responsible for neurodegenerative diseases like Alzheimer’s and dementia.
Thus good sleep is extremely essential for a healthy brain and body.
The build-up of toxins in the brain due to inadequate sleep also affects the body. Though there is very little understanding of how this happens, a probable cause is the passage of this information by the vagus nerve to different parts of the body.
Scientific investigations have also shown that information of any slight change in the brain chemistry is transmitted to various organs by the vagus nerve, which plays an important part in keeping the brain and body in unison.
As the brain starts getting affected by the debris build-up, the message via the vagus nerve to various organs might be to slow them down, resulting in their lethargic action.
Just like deep sleep, meditation also enables dissolution of memories. In fact, deep sleep and meditation have similar characteristics and it is quite possible that during meditation the flushing of toxins from the brain may also take place.
A possible mechanism could be that since meditation results in the relaxation of the brain, it may help in opening up the channels for flushing off the chemical debris.
Memory is formed both by producing new neural pathways and certain chemical changes in the brain. Memory removal, therefore, is affected by changes in both these mechanisms.
In deep meditation (where the focus is on a single thought for a long time, also called Sanyam) new neural pathways are formed and the old ones get dissolved. This dissolution may have a chemical signature thereby producing toxic debris which needs to be flushed out.
How can we induce good sleep? Generally, when the body is healthy and the person follows a good exercise regime, then this helps to produce deep sleep. Production of deep sleep can also be helped by meditation. Studies world over have shown that long-term practice of meditation helps in toning both the mind and body.
A good meditation practice to follow for quickly falling asleep is to close the eyes and focus attention on the center of the forehead. This can be done just before going to sleep and also when one wakes up at night and has difficulty in falling asleep again. (Anil K Rajvanshi, IANS)