Tuesday February 20, 2018

Scientists Discover a Genetic Variant that can Suppress the desire of Drinking Alcohol

A shift from heavy to moderate social drinking could have major public health benefits, such as reduced cardiovascular disease risk

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New York, November 29, 2016: In a step that could lead to development of drugs to regulate alcohol consumption, researchers have identified a gene variant that suppresses the desire for a drink.

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“The findings are based on the largest genome-wide association meta-analysis and replication study to date mapping and comparing the genetics — the DNA — of more than 105,000 light and heavy social drinkers,” said a corresponding author of the study David Mangelsdorf, Chair of Pharmacology at University of Texas Southwestern Medical Center.

“The study identified a variation in the beta-Klotho gene linked to the regulation of social alcohol consumption. The less frequent variant — seen in approximately 40 per cent of the people in this study — is associated with a decreased desire to drink alcohol,” he said.

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Like many complex traits, the genetic influences on brain functions affecting drinking behaviour were thought to be so small that it would be necessary to study large numbers of people in order to detect those genetic variations, Mangelsdorf said.

The study compared the genetics of light and heavy social drinkers of European ancestry participating in nearly four dozen other large population studies worldwide.

The findings, published online in the journal Proceedings of the National Academy of Sciences (PNAS), could lead to development of drugs to help those with drinking problems.

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A shift from heavy to moderate social drinking could have major public health benefits, such as reduced cardiovascular disease risk.

Increased alcohol consumption is linked to two heart disease risk factors in particular — high blood pressure and obesity, according to the American Heart Association. (IANS)

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World Heart Day 2017: 6 Simple Tips to Keep your Heart Healthy | NewsGram

How strong are your ABCDEF’s? Let’s find out!

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world heart day
September 29 is World Heart Day. Here is how you can care for your heart! Pixabay

New Delhi, September 29, 2017 : World Heart Day is here, and that gives us another reason to reiterate why you should be going an extra step to care for your heart. India accounts for 60 per cent of the world’s burden of heart diseases. This risk in Indians is almost double than their western counterparts and can be mainly attributed to genetics, diet and lifestyle.

An Increasing Trend of Heart Diseases

According to a WHO report released in mid-September, it was revealed that non-communicable diseases such as diabetes, heart diseases and cancer are an increasing cause of premature deaths all around the world, taking as many as 30 million lives annually. These diseases cause self-inflicted damage and trace their roots to individual lifestyle choices such as smoking, alcohol consumption, drugs and unhealthy or unbalanced diet.

ALSO READ Even less physically fit people can help themselves to prevent risk of Heart related Diseases: Study

Common Causes of Cardiovascular Diseases

Heart diseases are primarily caused because of accumulation of fats, cholesterol and other substances within and on the walls of the arteries. This is known as atherosclerosis.

This build-up begins from a young age and ultimately results in blockage of the arteries, which disabled the heart from pumping necessary quantity of blood. This, in turns, results in various disorders of the heart and the blood vessels.

Symptoms of Cardiovascular Diseases

Typical symptoms when your heart’s health is fluctuating will include chest pain or angina, breathlessness, sweating, palpitations and gastric pain. Some people may even complain of bloating or abdomen fullness.

Your heart is the reason your body is doing everything it can. So why not do something special for your heart on this World Heart Day?

World Heart Day 2017

World Heart Day is celebrated on September 29 and focuses on a holistic approach to generate awareness about cardiovascular disease.

A truly global initiative, World Heart Day is aimed to unite people from all corners of the world in the fight against cardiovascular diseases and encourage healthy hearts and healthy lifestyles across the world.

Heart diseases are the biggest man-made killer in India and the world. So what should be done on this World Heart Day to address the problem? All you have to do is keep your ABCDEF in check.

But how strong are your ABCDEF’s? Let’s find out!

6 Simple Tips To Keep your Heart Healthy Forever:

  • ABC: “A1c, Blood Sugar & Cholesterol” :

ABC remains for A1C, Blood Sugar, and Cholesterol individually. A1C is a test to check for glycated hemoglobin; it is fundamental to hold ABC levels in line for a more beneficial heart. You must also make it a habit to monitor your blood sugar and cholesterol levels and endeavor to keep the levels inside the recommended confines.

  • D : Diet  “Eat Heart Healthy Diet” :

You must consume a heart healthy diet that includes supplement-rich foods: Nutrition is critical to general well-being. As indicated by several nourishment researchers, a diet healthy for the heart, comprising of nutritious foods, for example, 1.5 servings (43 grams) of almonds may decrease levels of heart harming inflammation and additionally bring down aggregate and LDL cholesterol. Consumption of fish or salmon is also good for the heart as they are a rich source of Omega-3.

E : Exercise “Maintain a Healthy Waistline” :

It is a well established fact that a healthy waistline directly corresponds to cardiovascular well-being. Accumulation of fat on the stomach is directly proportional to rising blood sugar levels, high blood pressure, and soaring triglycerides level which are significant hazard factors for heart ailments. As previously revealed, consumption of 42 grams of almonds every day reduces belly fat and waist circumference- and increase in both of which are well-established coronary illness risk factors.

F : Fit Lifestyle “Fitness begins with an active lifestyle” :

As indicated by the American Heart Association, 150 minutes of moderately intense physical activity each week is prescribed for development in heart-health. Alternatively, you can also undertake 75 minutes of energetic or high-force exercise.

Physical activity is a boon for your heart; no amounts of healthy or controlled diet will prove beneficial unless complimented with a fit lifestyle.

Additionally, if your heart’s health is on your mind, then you must quit smoking.

Smoking harms the inner lining of the arteries and further deposits fat, thereby resulting in clogging. A cigarette may seem small, but its effect can be long lasting and ultimately result in death. These include a stroke, angina or a heart attack.

ALSO READ Worried About Your Heart’s Health? Make These 5 Spices a Part of Your Diet and See the Benefits Yourself!

These activities must not only be taken into account to celebrate World Health Day. Instead, aim to make them a part of every routine and witness how life changes for the better!

A little effort today will go a long way to keep you healthy and ready for all that life has to offer. On this World Heart Day, if you take a pledge to keep your ABCDEF’s under check, a healthy heart and a fit lifestyle are sure to follow!