Tuesday June 25, 2019

80 million diabetic in India by 2025: WHO report

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Sydney: Compared to those in the developed world, middle classes in India and other developing countries are more susceptible to Type-2 diabetes, obesity and cardiovascular diseases, thanks to their undernourished ancestors, says a study.

The results, published in the journal Cell Metabolism, could explain projections that more than 70 percent of the global burden of Type-2 diabetes will fall on individuals from developing countries by 2030.

According to the World Health Organisation (WHO), India will have 80 million people with diabetes by 2030.

Based on their results that eating a ‘normal’ diet can make animals overweight, if their ancestors had been undernourished for several generations, the researcher from University of Sydney in Australia, the National Centre for Cell Science and the DYP Medical College in Pune, India said that diabetes is linked to the nutrition endured by ancestors.

“People in developing countries have faced multi-generational undernutrition and are currently undergoing major lifestyle changes, contributing to an epidemic of metabolic diseases, though the underlying mechanisms remain unclear,” the study said.

Increasing prosperity in developing countries has been accompanied by a sudden increase in caloric intake.

However their populations’ epigenetic makeup, whereby changing environmental factors alter how people’s genes are expressed, has not compensated for these dietary changes.

This means their bodies are still designed to cope with undernourishment; so they store fat in a manner that makes them more prone to obesity and its resulting diseases than populations accustomed to several generations of a ‘normal’ diet.

This scenario was recreated in a 12-year study of two groups of rats by associated professor Anandwardhan Hardikar’s team at the University of Sydney and colleagues overseas.

The first group was undernourished for 50 generations and then put on a normal diet for two generations.

The second (control) group maintained a normal diet for 52 generations. At the end of the study it was found that when the descendants of the first group were exposed to a normal diet, these rats were eight times more likely to develop diabetes and multiple metabolic defects when compared to the control group.

“Their adverse metabolic state was not reversed by two generations of nutrient recuperation through a normal diet,” Hardikar said.

“Instead this newly prosperous population favoured storage of the excess nutrients as fat leading to increased obesity, cardiovascular disease and metabolic risk for diabetes when compared to their ‘developed world’ counterparts.”

Lower Vitamin B12 levels in the undernourished rats could also be an indicator of this trend, the study said.

“Human studies from Ranjan Yajnik’s group at KEM Hospital in Pune, India have demonstrated that low circulating B12 and high folate levels are associated with insulin resistance and Type-2 diabetes,” Hardikar said.

(IANS)

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Having a Cup of Coffee Can Help You Fight Obesity, Diabetes

“The results were positive and we now need to ascertain that caffeine as one of the ingredients in the coffee is acting as the stimulus or if there’s another component helping with the activation of brown fat. We are currently looking at caffeine supplements to test whether the effect is similar,” Symonds added

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A patron holds an iced beverage at a Starbucks coffee store in Pasadena, Calif., July 25, 2013. VOA

Drinking a cup of coffee can be helpful in fighting obesity and diabetes as it stimulates body’s fat-fighting defences, says a new study.

The study, published in Scientific Reports journal, found components which could have a direct effect on “brown fat” functions, an important part of the human body which plays a key role in how quickly we can burn calories as energy.A

Brown adipose tissue (BAT), also known as brown fat, is one of two types of fat found in humans and other mammals. Its main function is to generate body heat by burning calories (opposed to white fat, which is a result of storing excess calories).

People with a lower body mass index (BMI) therefore have a higher amount of brown fat.

“Brown fat works in a different way to other fat in your body and produces heat by burning sugar and fat, often in response to cold. Increasing its activity improves blood sugar control as well as improving blood lipid levels and the extra calories burnt help with weight loss,” said study’s co-director Michael Symonds, Professor at the University of Nottingham.. A

“This is the first study in humans to show that something like a cup of coffee can have a direct effect on our brown fat functions. The potential implications of our results are pretty big, as obesity is a major health concern for society and we also have a growing diabetes epidemic and brown fat could potentially be part of the solution in tackling them,” he noted.

A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. State health officials proposed a regulation change Friday that would declare coffee doesn't present a significant cancer risk, countering a California court ruling.
A barista pours steamed milk into a cup of coffee at a cafe in Los Angeles, Sept. 22, 2017. VOA

For the study, the researcehes started with a series of stem cell studies to see if caffeine would stimulate brown fat. After finding the right dose, they then moved on to humans to see if the results were similar.

They used a thermal imaging technique to trace the body’s brown fat reserves. The non-invasive technique helps the team to locate brown fat and assess its capacity to produce heat.

“From our previous work, we knew that brown fat is mainly located in the neck region, so we were able to image someone straight after they had a drink to see if the brown fat got hotter,” he said.

Also Read: Poor Sleep Quality Associated with Reduced Memory in Senior Citizens

“The results were positive and we now need to ascertain that caffeine as one of the ingredients in the coffee is acting as the stimulus or if there’s another component helping with the activation of brown fat. We are currently looking at caffeine supplements to test whether the effect is similar,” Symonds added.

“Once we have confirmed which component is responsible for this, it could potentially be used as part of a weight management regime or as part of glucose regulation programme to help prevent diabetes,” he concluded. (IANS)