Tuesday March 26, 2019

Anti-stress hormone linked to breast cancer risk

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London: Women with low levels of an anti-stress hormone have an increased risk of getting breast cancer, says a new study.

The study focused on a hormone which circulates freely in the blood, enkephalin, with pain- and anxiety-reducing properties. Enkephalin also reinforces the immune system by directly affecting immune cells. Credits: https://www.google.co.in/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0CAYQjB1qFQoTCPiMsv7f3MYCFcUrpgodVqIA4Q&url=http%3A%2F%2Fwww.choctawnation.com%2Fnews-room%2Fpress-room%2Fmedia-releases%2Fchoctaw-bike-team-encourages-breast-cancer-awareness%2F&ei=CB6mVfjoO8XXmAXWxIKIDg&bvm=bv.97653015,d.eXY&psig=AFQjCNEi8zFFmDRriJ0iC8kBpejk9sc6Iw&ust=1437035987055497

“Among women with the lowest levels of the hormone, the risk of breast cancer was more than three times that of the women with the highest levels of the hormone. This is one of the strongest correlations between cancer risk and a freely circulating biomarker ever described,” said Olle Melander, professor at Lund University, Sweden.

The study that appeared in the Journal of Clinical Oncology, was based on blood samples taken from over 1,900 women. The average age of the women studied was 57. The women were followed up with regard to breast cancer for an average period of 15 years.

The researchers said geographical location and age, in spite of the adjustments in the study, may be significant. After further studies, the results will facilitate prevention and early detection of breast cancer.

For those with an increased risk of breast cancer, potential preventive treatments could take the form of lifestyle interventions to reduce stress and new drugs.

“Our immediate plan is to investigate how to affect the level of enkephalin in healthy individuals. We will do this primarily in a study with a smaller number of women. We are also interested in the hormone’s role in other cancers,” said co-author Mattias Belting and professor at Lund University, Sweden.

( IANS)

Next Story

Exposure to Dim Light Escalates Breast Cancer’s Spread to Bones

X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle

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Cancer
Cancer Ribbon. Pixabay

Exposure to dim light at night may contribute to spreading of breast cancer to bones, researchers have shown in an animal study.

When breast cancer spreads it often affects bones, cause severe pain and make them fragile. “To date no one has reported that exposure to dim light at night induces circadian disruption, which increases spread of bone metastatic breast cancer,” said Muralidharan Anbalagan, Assistant Professor, at Tulane University in New Orleans.

The findings were presented at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans.

For the preliminary study, the team created a mouse model of bone metastatic breast cancer. They injected oestrogen receptor-positive human breast cancer cells, which have a low propensity to grow in bones, into the tibia (shinbone) of female mice.

Cancer patient
Cancer patient.

Like humans, mice produced a strong night-time circadian melatonin signal, shown to produce strong anti-cancer actions and for promoting sleep.

While one group of mice was kept in the light for 12 hours each day, the other group of three mice in the dark for 12 hours. Another group spent 12 hours in light, followed by 12 hours in dim light at night.

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X-ray images showed that mice exposed to a light or dim light cycle had much larger tumours and increased bone damage compared with mice kept in a standard light/dark cycle, he noted.

“Our research identified the importance of an intact nocturnal circadian melatonin anti-cancer signal in suppressing bone-metastatic breast tumour growth,” Anbalagan said. (IANS)