Friday July 20, 2018

Aspirin can restrict the growth of breast cancer, says Indian- origin researcher

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New York: A study led by an Indian-origin researcher has found a daily dose of aspirin is effective at blocking breast tumour growth in laboratory tests.

Aspirin is used worldwide as a ‘blood thinner’ and to relieve inflammation, pain and fever.

“The trick is to ensure conditions around cancer stem cells are not conducive for reproduction, something aspirin seems to be able to do,” said Sushanta Banerjee, professor at the University of Kansas Medical Centre in the US.

“We could give aspirin after chemotherapy to prevent relapse and keep the pressure on, which we saw was effective in both the laboratory and the mouse model, and we could use it preventatively,” Banerjee noted.

Experts suggest patients to consult with a doctor before starting a daily aspirin regimen. The drug is known to thin the blood and increase the risk of gastrointestinal bleeding.

“Of course there is a risk, but you have to weigh that against the risks of cancer,” Banerjee said.

To test his theory that aspirin could alter the molecular signature in breast cancer cells enough so that they would not spread, Banerjee used both incubated cells and mouse models.

For the cell test, breast cancer cells were placed in 96 separate plates and then incubated. Just over half the cultures were exposed to differing doses of acetylsalicylic acid, commonly known as aspirin.

According to Banerjee, exposure to aspirin dramatically increased the rate of cell death in the test. For those cells that did not die off, many were left unable to grow.

The second part of his study involved studying 20 mice with aggressive tumours.

For 15 days, half of the mice were given the human equivalent of 75 milligrams of aspirin per day, which is considered a low dose.

At the end of the study period, the tumours were weighed. Mice that received aspirin had tumours that were, on an average, 47 percent smaller.

To show that aspirin could also prevent cancer, the researchers gave an additional group of mice aspirin for 10 days before exposing them to cancer cells.

After 15 days, those mice had significantly less cancerous growth than the control group.

“We found aspirin caused these residual cancer cells to lose their self-renewal properties,” Banerjee said.

The study is to appear in the forthcoming issue of the journal Laboratory Investigation. (IANS)

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Eating Dinner Early May Lower Risk of Breast, Prostate Cancer

The research suggests that long-term late night snacking may have the similar effect to night-shift work and circadian disruption

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The researchers found that cancer patients were more likely to have dinner late at night. Pixabay

Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer, suggests a new study.

Compared to those who have supper after 10 pm or those who go to bed right after meal, people who take their evening meal before 9 pm or wait at least two hours before going to sleep have approximately 20 per cent lower risk of those types of cancers, the findings showed.

“Our study concludes that adherence to diurnal eating patterns is associated with a lower risk of cancer,” said lead author Manolis Kogevinas from the Barcelona Institute for Global Health (ISGlobal) in Spain.

“The findings highlight the importance of assessing circadian rhythms in studies on diet and cancer,” Kogevinas added.

For the study, published in International Journal of Cancer, the team analysed data from 621 cases of prostate cancer and 1,205 cases of breast cancer, as well as 872 male and 1,321 female controls.

Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer
Having your last meal before 9 pm or at least two hours before going to bed could lower the risk of breast and prostate cancer. Pixabay

The participants, were interviewed about their meal timing, sleep habits and chronotype — an individual attribute correlating with preference for morning or evening activity.

The participants also completed a questionnaire on their eating habits and adherence to cancer prevention recommendations.

The researchers found that cancer patients were more likely to have dinner late at night.

Also Read: Meditation Improves Mood, Sleep in Teenagers with Cancer

Breast and prostate cancers are also among those most strongly associated with night-shift work, circadian disruption and alteration of biological rhythms.

The research suggests that long-term late night snacking may have the similar effect to night-shift work and circadian disruption.

“If the findings are confirmed, they will have implications for cancer prevention recommendations, which currently do not take meal timing into account,” Kogevinas noted. (IANS)