Monday July 16, 2018

Ayurvedic Pharmacy: Indian researcher Vandana Gulati uses plants for diabetes treatment

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Melbourne:  An Indian researcher currently pursuing Ph.D in Australia is conducting a study to test the use of plants in the treatment of diabetes and cancer, a media report said on Wednesday.

Vandana Gulati, who is currently pursuing her Ph.D at Melbourne’s Swinburne University of Technology and was involved with pharmaceutical research in India after completing her masters in ayurvedic pharmacy, has investigated 12 medicinal plant extracts and their applications in treatment of diabetes and cancer, reported Melbourne-based Indian Link newspaper.

“When we moved here, we found that people had reservations about the effectiveness of plant-based research. There were a few groups working in this field, however, majority were not receptive to the idea,” she said.

Previous studies have found that diabetes and cancer are linked, as the risk of low insulin in diabetes affects the growth of cancer cells.

Preliminary research has shown that witchetty bush (Acacia kempeana) and Australian sandalwood (Santalum spicatum) stimulate glucose uptake in fat cells, while dead finish (Acacia tetragonophylla), turpentine bush (Beyeria Ieshnaultii) and caustic weed (Euphorbia drumondii) significantly reduced fat accumulation in fat cells. The witchetty bush and dead finish also showed strong activity against cervical cancer cells.

“There are still many experiments that need to be completed on the cells, followed by testing on animals and finally a trial on humans directly. However, we are very positive of the outcome,” Gulati added.

-IANS

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Omega-3 Fatty Acids in Diet can Prevent Cancer From Spreading

While dietary consumption of omega-3 fatty acids can lead to EDP-EAs, for those with cancer, something concentrated and fast acting is needed

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The results showed that the endocannabinoids slowed the growth of tumours and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death.
The results showed that the endocannabinoids slowed the growth of tumours and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death. (IANS)

While eating foods rich in omega-3 fatty acids, such as fatty fish, certain nuts and seeds, have been known to prevent heart diseases and arthritis, a new research, led by one of Indian-origin, showed that omega-3 fatty byproducts may also have anti-cancer effects.

The new study, led by Aditi Das from University of Illinois at Urbana-Champaign, US, showed that when the human body metabolises omega-3 fatty acids, it produces a class of molecules called endocannabinoid epoxides, or EDP-EAs. These have anti-inflammatory properties and can inhibit cancer’s growth and spread.

The EDP-EAs have similar properties to cannabinoids found in marijuana — but without the psychotropic effects — and they target the same receptor in the body that cannabis does.

“We have a built-in endocannabinoid system which is anti-inflammatory and pain-reducing. Now we see it is also anti-cancer, stopping the cells from proliferating or migrating,” said study leader Aditi Das from University of Illinois at Urbana-Champaign.

The higher concentrations of EDP-EAs did kill cancer cells, but not as effectively as other chemotherapeutic drugs on the market.
The higher concentrations of EDP-EAs did kill cancer cells, but not as effectively as other chemotherapeutic drugs on the market. Pixabay

“These molecules could address multiple problems: cancer, inflammation and pain,” Das added.

For the study, published in the Journal of Medicinal Chemistry, the team studied the effect of the molecule in mice with tumours of osteosarcoma — a bone cancer that is not only painful but also difficult to treat.

The results showed that the endocannabinoids slowed the growth of tumours and blood vessels, inhibited the cancer cells from migrating and caused cancer cell death.

The higher concentrations of EDP-EAs did kill cancer cells, but not as effectively as other chemotherapeutic drugs on the market. But, the compounds slowed tumour growth by inhibiting new blood vessels from forming to supply the tumour with nutrients. They also prevented interactions between the cells, and most significantly, they appeared to stop cancerous cells from migrating.

Also Read: Cancer-Causing Chemical Found In Odisha Fish Sample

While dietary consumption of omega-3 fatty acids can lead to EDP-EAs, for those with cancer, something concentrated and fast acting is needed, Das said.

“That’s where the endocannabinoid epoxide derivatives come into play – you could make a concentrated dose of the exact compound that’s most effective against the cancer. You could also mix this with other drugs such as chemotherapies,” she added. (IANS)