Monday March 18, 2019

Bacterial Heart Infections May Increase Due To Injection Of Drugs: Study

The increase in the risk of infective endocarditis is consistent with the findings of other studies

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HIV, Drugs
More than half of the people surveyed who inject drugs said they avoided health-care services, citing discrimination or fear of law enforcement authorities.VOA

People who inject drugs may have a significant increase in the risk of infective endocarditis, a serious infection of the lining of the heart, possibly linked to increasing use of the opioid hydromorphone, a new study suggests.

“We observed a substantial increase in the risk of infective endocarditis among people who inject drugs, which is associated with hydromorphone’s increasing share of the prescription opioid market,” said researchers, including first author Matthew Weir from Western University, London, Ontario.

For the study, published in the Canadian Medical Association Journal, researchers looked at Ontario data on drug users from linked health administrative databases between April 2006 and September 2015.

drugs, himachal
There are countless mothers who have been constantly tormented by drug-dependent adolescent children. Pixabay

There were 60,529 admissions to hospital of people who inject drugs and, of these, 733 had infective endocarditis linked to injecting drugs.

Although admission rates for people who inject drugs were stable over the study period, the risk of infective endocarditis increased from 13.4 admissions every three months (fourth quarter 2011) to 35.1 admissions every three months in the period afterwards.

Whereas the percentage of opioid prescriptions attributed to controlled-release oxycodone declined rapidly when it was removed from the market by its manufacturer in the fourth quarter of 2011, hydromorphone prescriptions increased from 16 per cent at the start of the study to 53 per cent by the end, the researcher said.

Heart Attack, women
Anti-inflammatory drugs may put you at heart attack risk.
Pixabay

The team expected that an increase in risk of infective endocarditis would occur when controlled-release oxycodone was removed from the Canadian market; however, they found that the rise began before removal.

Also Read: Shortage Of Blood Pressure Drugs After Recall: FDA

“Although our observations do not support our hypothesis that the loss of controlled-release oxycodone increased the use of hydromorphone, they do support our suspicion that hydromorphone may be playing a role in the increasing risk of infective endocarditis,” said co-author Michael Silverman from the varsity.

The increase in the risk of infective endocarditis is consistent with the findings of other studies, but the observed timing of the increase was novel, the team said.

“Both the rise in this severe complication of injection drug use and the possible association with hydromorphone require further study,” the authors noted. (IANS)

Next Story

Study Reveals Medicine Taken To Treat High Blood Pressure Can Lead An Increased Risk of Sudden Cardiac Arrest

The results, presented at the annual congress of European Heart Rhythm Association 2019 in Lisbon, showed that high-dose (60 mg/day) nifedipine was significantly associated with an increased risk of out-of-hospital cardiac arrest with any dose of amlodipine. 

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drugs
"Nifedipine and amlodipine are often used by many cardiologists and other physicians, and the choice often depends on the prescriber's preference and personal experience," said Hanno Tan, cardiologist at the Academic Medical Center. VOA

A drug commonly used to treat high blood pressure and chest pain could be associated with an increased risk of sudden cardiac arrest, according to a study.

Doctors from the Academic Medical Center in Amsterdam, the Netherlands, examined over 60,000 people to determine whether nifedipine and amlodipine or dihydropyridines — widely used for high blood pressure and angina — were linked with out-of-hospital cardiac arrest.

The results, presented at the annual congress of European Heart Rhythm Association 2019 in Lisbon, showed that high-dose (60 mg/day) nifedipine was significantly associated with an increased risk of out-of-hospital cardiac arrest with any dose of amlodipine.

heart
In sudden cardiac arrest, the heart stops pumping after a cardiac arrhythmia (ventricular fibrillation/tachycardia). This can be lethal if untreated. Pixabay

There was no risk associated with amlodipine.

“Nifedipine and amlodipine are often used by many cardiologists and other physicians, and the choice often depends on the prescriber’s preference and personal experience,” said Hanno Tan, cardiologist at the Academic Medical Center.

B.P
A drug commonly used to treat high blood pressure and chest pain could be associated with an increased risk of sudden cardiac arrest, according to a study. Pixabay

The findings are surprising given that both the drugs have been in use for many years.

However, the researchers urged caution when interpreting the results.

Also Read: Planning A Major Vigil And Memorial, Place to Grieve for Shaken Christchurch Residents

“The findings need to be replicated in other studies before action could be taken by doctors or patients,” Tan said.

In sudden cardiac arrest, the heart stops pumping after a cardiac arrhythmia (ventricular fibrillation/tachycardia). This can be lethal if untreated. (IANS)